Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Bcl-2 family proteins

1998 • 1,055 citations

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase

1985 • 961 citations

Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction

1998 • 874 citations

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1997 • 801 citations

The Regulation of Reactive Oxygen Species Production during Programmed Cell Death

1998 • 719 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 670 citations

Cardiolipins and biomembrane function

1992 • 597 citations

Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1

1998 • 580 citations

Cytochrome c in the apoptotic and antioxidant cascades

1998 • 491 citations

Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells

1998 • 382 citations

Thioredoxin Peroxidase Is a Novel Inhibitor of Apoptosis with a Mechanism Distinct from That of Bcl-2

1997 • 372 citations

Lysenin, a Novel Sphingomyelin-specific Binding Protein

1998 • 334 citations

Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Plays a Major Role in Preventing Oxidative Injury to Cells

1999 • 296 citations

Overexpression of Catalase in Cytosolic or Mitochondrial Compartment Protects HepG2 Cells against Oxidative Injury

1999 • 288 citations

Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Suppresses Apoptosis Mediated by a Mitochondrial Death Pathway

1999 • 285 citations

Redistribution of phosphatidylethanolamine at the cleavage furrow of dividing cells during cytokinesis

1996 • 260 citations

Reversibility of the Binding of Cytochrome c to Liposomes

1995 • 258 citations

Evidence for two distinct acidic phospholipid-binding sites in cytochrome c.

1994 • 254 citations

Loss of Molecular Interaction between Cytochrome c and Cardiolipin Due to Lipid Peroxidation

1999 • 248 citations

The reconstituted ADP/ATP carrier activity has an absolute requirement for cardiolipin as shown in cysteine mutants.

1994 • 210 citations

Diphosphatidylglycerol is required for optimal activity of beef heart cytochrome c oxidase.

1981 • 172 citations

Suppression of Leukotriene Formation in RBL-2H3 Cells That Overexpressed Phospholipid Hydroperoxide Glutathione Peroxidase

1998 • 168 citations

Nitric Oxide–Induced Apoptosis in Human Leukemic Lines Requires Mitochondrial Lipid Degradation and Cytochrome C Release

1999 • 152 citations

Mass Spectrometric Identification of Increased C16 Ceramide Levels During Apoptosis

1999 • 148 citations

Prevention of Mitochondrial Injury by Manganese Superoxide Dismutase Reveals a Primary Mechanism for Alkaline-induced Cell Death

1998 • 139 citations

NMR and ESR studies of the interactions of cytochrome c with mixed cardiolipin-phosphatidylcholine vesicles

1977 • 133 citations

Induction of Apoptosis in Human T-Cells by Methyl Mercury: Temporal Relationship between Mitochondrial Dysfunction and Loss of Reductive Reserve

1999 • 127 citations

Characterization of cysteine residues of mitochondrial ADP/ATP carrier with the SH-reagents eosin 5-maleimide and N-ethylmaleimide.

1993 • 124 citations

Import into Mitochondria of Phospholipid Hydroperoxide Glutathione Peroxidase Requires a Leader Sequence

1996 • 122 citations

A Conformational Change in Cytochromecof Apoptotic and Necrotic Cells Is Detected by Monoclonal Antibody Binding and Mimicked by Association of the Native Antigen with Synthetic Phospholipid Vesicles

1999 • 117 citations

Purification and characterization of phospholipid hydroperoxide glutathione peroxidase from rat testis mitochondrial membranes

1994 • 115 citations

Overexpression of manganese superoxide dismutase protects against mitochondrial‐initiated poly(ADP‐ribose) polymerase‐mediated cell death

1999 • 102 citations

Direct Cardiolipin Assay in Yeast Using the Red Fluorescence Emission of 10-N-Nonyl Acridine Orange

1995 • 100 citations

Differential interactions of apo- and holocytochrome c with acidic membrane lipids in model systems and the implications for their import into mitochondria

1989 • 96 citations

Role of superoxide in apoptosis induced by growth factor withdrawal

1998 • 90 citations

Cytochrome c-lipid interactions studied by resonance Raman and phosphorus-31 NMR spectroscopy. Correlation between the conformational changes of the protein and the lipid bilayer

1991 • 87 citations

Direct Cardiolipin Assay in Yeast Using the Red Fluorescence Emission of 10-N-Nonyl Acridine Orange

1995 • 84 citations

Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase Suppressed Cell Death Due to Oxidative Damage in Rat Basophile Leukemia Cells (RBL-2H3)

1996 • 77 citations

Distribution of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in rat testis mitochondria

1994 • 67 citations

Molecular Cloning and Functional Expression of a cDNA for Rat Phospholipid Hydroperoxide Glutathione Peroxidase: 3'-Untranslated Region of the Gene Is Necessary for Functional Expression

1995 • 64 citations

Changes of Mitochondrial Mass in the Hemopoietic Stem Cell Line FDCP-Mix after Treatment with Etoposide: A Correlative Study by Multiparameter Flow Cytometry and Confocal and Electron Microscopy

1995 • 55 citations

[33] Chemiluminescence-based high-performance liquid chromatography assay of lipid hydroperoxides

1994 • 53 citations

Assay of cardiolipin peroxidation by high-performance liquid chromatography

1988 • 37 citations

Sequence of Metabolic Changes during X-Ray-Induced Apoptosis

1999 • 36 citations

Natural autoantibody against apolipoprotein A-I. Detection and characterization of the monoclonal antibody established from normal unimmunized BALB/c mice.

1994 • 18 citations

Nitric Oxide–Induced Apoptosis in Human Leukemic Lines Requires Mitochondrial Lipid Degradation and Cytochrome C Release

1999 • 14 citations

Cellular Glutathione Peroxidase as a Predominant Scavenger of Hydroperoxyeicosatetraenoic Acids in Rabbit Alveolar Macrophages.

1999 • 13 citations