THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

1997 • 1,218 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

The biochemistry of programmed cell death

1995 • 997 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Apoptosis in Ischemic and Reperfused Rat Myocardium

1996 • 801 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity

1996 • 768 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.

1992 • 692 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

Mitochondrial Depolarization in Glutamate-Stimulated Neurons: An Early Signal Specific to Excitotoxin Exposure

1996 • 610 citations

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis.

1995 • 598 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Protection by Cyclosporin A of Ischemia/Reperfusion-Induced Damage in Isolated Rat Hearts

1993 • 571 citations

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

1997 • 555 citations

Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites

1996 • 522 citations

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death

1997 • 470 citations

The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal

1996 • 466 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

Constitutive expression of the machinery for programmed cell death.

1996 • 386 citations

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

1995 • 384 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

Complex I Inhibitors Induce Dose‐Dependent Apoptosis in PC12 Cells: Relevance to Parkinson's Disease

1994 • 365 citations

Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis.

1996 • 353 citations

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

1996 • 336 citations

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

1996 • 335 citations

Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40.

1994 • 320 citations

Synthetic Glucocorticoids That Dissociate Transactivation and AP-1 Transrepression Exhibit Antiinflammatory Activityin Vivo

1997 • 310 citations

Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

1997 • 309 citations

Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents.

1997 • 302 citations

Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors.

1996 • 300 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

Structure-Function Comparisons of the Proapoptotic Protein Bax in Yeast and Mammalian Cells

1996 • 280 citations

Protective Effect of N-Acetylcysteine in Tumor Necrosis Factor-α-Induced Apoptosis in U937 Cells: The Role of Mitochondria

1995 • 274 citations

DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis.

1995 • 271 citations

The Cytotoxicity of Tumor Necrosis Factor Depends on Induction of the Mitochondrial Permeability Transition

1996 • 266 citations

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1991 • 261 citations

Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions.

1996 • 260 citations

Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.

1995 • 243 citations

Mitochondrial permeability transition triggers lymphocyte apoptosis.

1996 • 238 citations

Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes

1996 • 227 citations

Bcl-x_Lcan inhibit apoptosis in cells that have undergone Fas-induced protease activation

1997 • 222 citations

Redox regulation of apoptosis: Impact of thiol oxidation status on mitochondrial function

1997 • 214 citations

Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: protection by fructose, cyclosporin A and trifluoperazine.

1993 • 213 citations

The Peptide Mastoparan Is a Potent Facilitator of the Mitochondrial Permeability Transition

1995 • 207 citations

Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA.

1996 • 202 citations

Release of Cytochrome c from Liver Mitochondria during Permeability Transition

1997 • 197 citations

Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage

1996 • 186 citations

Involvement of Cellular Proteolytic Machinery in Apoptosis

1997 • 184 citations

Chloromethyl-X-rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis

1996 • 178 citations

Correspondence

1996 • 164 citations

The ICE family of cysteine proteases as effectors of cell death.

1996 • 158 citations

On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide

1995 • 146 citations

Peroxynitrite causes calcium efflux from mitochondria which is prevented by Cyclosporin A

1994 • 143 citations

Diverse molecular provocation of programmed cell death

1996 • 137 citations

Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone.

1994 • 133 citations

Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: A laser scanning confocal microscopic study

1995 • 128 citations

Synthetic Glucocorticoids That Dissociate Transactivation and AP-1 Transrepression Exhibit Antiinflammatory Activity in Vivo

1997 • 118 citations

Novel mechanisms in chemically induced hepatotoxicity ¹

1994 • 108 citations

Bcl-2 and Hsp27 act at different levels to suppress programmed cell death

1997 • 96 citations

Cyclosporin A protects hepatocytes subjected to high Ca²⁺ and oxidative stress

1992 • 96 citations

Cyclosporin a protects hepatocytes against prooxidant-induced cell killing

1992 • 94 citations

Direct Interaction of the Mitochondrial Membrane Protein Carnitine Palmitoyltransferase I with Bcl-2

1997 • 92 citations

Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition

1995 • 79 citations

The Pharmacology of T Cell Apoptosis

1995 • 77 citations

Kainate induces apoptosis in neurons

1996 • 67 citations

Perspectives on the mitochondrial multiple conductance channel

1996 • 64 citations

Activation of apoptosis during the reperfusion phase after rat liver ischemia.

1996 • 63 citations

Diverse molecular provocation of programmed cell death

1996 • 60 citations

Phagocyte recognition of apoptotic cells

1996 • 42 citations

Protection by cyclosporin A of cultured hepatocytes from the toxic consequences of the loss of mitochondrial energization produced by 1-methyl-4-phenylpyridinium

1992 • 41 citations

A Mitochondrial Signal Peptide fromNeurospora crassaIncreases the Permeability of Isolated Rat Liver Mitochondria

1996 • 39 citations

Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: A laser scanning confocal microscopic study*1, *2

1995 • 29 citations

Detection of apoptosis and apoptosis-associated alterations

1996 • 21 citations

Detection of apoptosis and apoptosis- associated alterations

1996 • 10 citations