Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

The Bcl2 family: regulators of the cellular life-or-death switch

2002 • 3,782 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

2004 • 1,977 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

2002 • 1,443 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

2003 • 1,298 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

2000 • 754 citations

Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

2004 • 748 citations

Conformation of the Bax C-terminus regulates subcellular location and cell death

1999 • 723 citations

Structural biology of the Bcl-2 family of proteins

2003 • 706 citations

Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells

2001 • 676 citations

Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis

2001 • 620 citations

BNIP3 and Genetic Control of Necrosis-Like Cell Death through the Mitochondrial Permeability Transition Pore

2000 • 605 citations

Cardiolipin provides specificity for targeting of tBid to mitochondria

2000 • 462 citations

BID regulation by p53 contributes to chemosensitivity

2002 • 412 citations

p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.

1998 • 363 citations

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

1997 • 357 citations

Characterization of the signal that directs Bcl-xL, but not Bcl-2, to the mitochondrial outer membrane

2003 • 343 citations

BNIP3 Heterodimerizes with Bcl-2/Bcl-XL and Induces Cell Death Independent of a Bcl-2 Homology 3 (BH3) Domain at Both Mitochondrial and Nonmitochondrial Sites

2000 • 337 citations

BAX Translocation Is a Critical Event in Neuronal Apoptosis: Regulation by Neuroprotectants, BCL-2, and Caspases

1999 • 314 citations

Tissue-specific induction of p53 targets in vivo.

2002 • 224 citations

Association of Bax and Bak Homo-oligomers in Mitochondria

2003 • 216 citations

Regulation of p53 localization

2001 • 208 citations

Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein

2002 • 192 citations

Diva, a Bcl-2 Homologue that Binds Directly to Apaf-1 and Induces BH3-independent Cell Death

1998 • 170 citations

Differential Mechanisms of Neuroprotection by 17 β-Estradiol in Apoptotic versus Necrotic Neurodegeneration

2001 • 158 citations

BOK and NOXA Are Essential Mediators of p53-dependent Apoptosis

2004 • 152 citations

Bcl-rambo, a Novel Bcl-2 Homologue That Induces Apoptosis via Its Unique C-terminal Extension

2001 • 139 citations

Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL

1998 • 129 citations

17β-Estradiol Prevents Dysfunction of Canine Coronary Endothelium and Myocardium and Reperfusion Arrhythmias After Brief Ischemia/Reperfusion

1996 • 102 citations

Expression of 11 members of the BCL‐2 family of apoptosis regulatory molecules during human preimplantation embryo development and fragmentation

2004 • 102 citations

CD47 and the 19 kDa Interacting Protein-3 (BNIP3) in T Cell Apoptosis

2003 • 91 citations

Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway

2001 • 70 citations

Chromosome‐9 loss detected by fluorescence in situ hybridization in bladder cancer

1995 • 61 citations

Redistribution of Bax from Cytosol to Membranes Is Induced by Apoptotic Stimuli and Is an Early Step in the Apoptotic Pathway

1998 • 43 citations

The Bcl‐2 family pro‐apoptotic molecule, BNIP3 regulates activation‐induced cell death of effector cytotoxic T lymphocytes

2003 • 32 citations

Helix 6 of tBid is necessary but not sufficient for mitochondrial binding activity.

2003 • 25 citations