Cytochrome c release precedes mitochondrial membrane potential loss in cerebellar granule neuron apoptosis: lack of mitochondrial swelling

Antibodies, a laboratory manual

1989 • 12,929 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Antibodies: A laboratory manual

1989 • 4,532 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

2000 • 1,046 citations

J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

1991 • 1,017 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis

2001 • 466 citations

Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process

2001 • 431 citations

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

2000 • 415 citations

The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and Cytochrome c Release

1998 • 400 citations

Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells

2001 • 360 citations

Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c

1997 • 348 citations

Mitochondrial Depolarization Accompanies Cytochrome cRelease During Apoptosis in PC6 Cells

1999 • 347 citations

The Release of Cytochrome c from Mitochondria during Apoptosis of NGF-deprived Sympathetic Neurons Is a Reversible Event

1999 • 297 citations

Activation of the CED3/ICE-Related Protease CPP32 in Cerebellar Granule Neurons Undergoing Apoptosis But Not Necrosis

1997 • 284 citations

Preservation of Mitochondrial Structure and Function after Bid- or Bax-Mediated Cytochrome c Release

2000 • 244 citations

Mitochondrial Membrane Potential and Nuclear Changes in Apoptosis Caused by Serum and Nerve Growth Factor Withdrawal: Time Course and Modification by (−)-Deprenyl

1998 • 232 citations

Metabolic and Genetic Analyses of Apoptosis in Potassium/Serum-Deprived Rat Cerebellar Granule Cells

1996 • 216 citations

Caspase-Dependent and -Independent Death of Camptothecin-Treated Embryonic Cortical Neurons

1999 • 200 citations

Mitochondrial Depolarization Is Not Required for Neuronal Apoptosis

1999 • 184 citations

Caspase Inhibition Extends the Commitment to Neuronal Death Beyond Cytochrome c Release to the Point of Mitochondrial Depolarization

2000 • 183 citations

Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator

2000 • 166 citations

Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector

1998 • 164 citations

Blocking Cytochrome c Activity within Intact Neurons Inhibits Apoptosis

1998 • 161 citations

Evidence for Redox Regulation of Cytochrome c Release during Programmed Neuronal Death: Antioxidant Effects of Protein Synthesis and Caspase Inhibition

2001 • 127 citations

Apoptosis of Retrogradely Degenerating Neurons Occurs in Association with the Accumulation of Perikaryal Mitochondria and Oxidative Damage to the Nucleus

1998 • 104 citations

Chromaffin cell death induced by 6‐hydroxydopamine is independent of mitochondrial swelling and caspase activation

2003 • 83 citations

Two mechanisms by which ATP depletion potentiates induction of the mitochondrial permeability transition

1997 • 83 citations

Staurosporine-induced neuronal death: multiple mechanisms and methodological implications

2000 • 67 citations

Calphostin C-mediated translocation and integration of Bax into mitochondria induces cytochrome c release before mitochondrial dysfunction

2000 • 39 citations