A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth

On the Origin of Cancer Cells

1956 • 12,141 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer

2000 • 2,394 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

Measurement of Mitochondrial Membrane Potential Using Fluorescent Rhodamine Derivatives

1999 • 1,156 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Oncogenic alterations of metabolism

1999 • 1,095 citations

The biology of erbB-2/nue/HER-2 and its role in cancer

1994 • 975 citations

Mitochondria and cell death

1999 • 763 citations

Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes

1998 • 715 citations

Biology of HER2 and Its Importance in Breast Cancer

2001 • 710 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Mitochondrion as a Novel Target of Anticancer Chemotherapy

2000 • 536 citations

Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells

2001 • 523 citations

The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells.

2001 • 516 citations

The basic biology of HER2

2001 • 443 citations

Receptor tyrosine kinase signalling as a target for cancer intervention strategies.

2001 • 378 citations

Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells.

1982 • 356 citations

ErbB2 Potentiates Breast Tumor Proliferation through Modulation of p27^Kip1-Cdk2 Complex Formation: Receptor Overexpression Does Not Determine Growth Dependency

2000 • 304 citations

Mitochondria, oxygen free radicals, and apoptosis

2001 • 300 citations

Mitochondria Exert a Negative Feedback on the Propagation of Intracellular Ca2+ Waves in Rat Cortical Astrocytes

1999 • 295 citations

Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion

1992 • 236 citations

The Role of a Mitochondrial Pathway in the Induction of Apoptosis by Chemicals Extracted from Diesel Exhaust Particles

2000 • 206 citations

Basis for the selective cytotoxicity of rhodamine 123.

1987 • 201 citations

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

1999 • 200 citations

Rhodamine-123 Selectively Reduces Clonal Growth of Carcinoma Cells in Vitro

1982 • 179 citations

On the Voltage Dependence of the Mitochondrial Permeability Transition Pore

1997 • 179 citations

MKT-077, a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation.

1996 • 176 citations

Tyrosine Kinase Inhibitors Targeted to the Epidermal Growth Factor Receptor Subfamily

2000 • 170 citations

The role of overexpressed HER2 in transformation

2001 • 163 citations

Tumor suppressor p53: regulation and function

2000 • 153 citations

Increased rhodamine 123 uptake by carcinoma cells.

1985 • 151 citations

On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide

1995 • 146 citations

Rhodamine 123 inhibits bioenergetic function in isolated rat liver mitochondria

1984 • 132 citations

Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.

1996 • 123 citations

Phase I trial of the selective mitochondrial toxin MKT 077 in chemo-resistant solid tumours

1999 • 122 citations

Chloromethyltetramethylrosamine (Mitotracker OrangeTM) Induces the Mitochondrial Permeability Transition and Inhibits Respiratory Complex I

1999 • 116 citations

Down-regulation of HER2/neu expression induces apoptosis in human cancer cells that overexpress HER2/neu.

2000 • 107 citations

A phase I and pharmacokinetic study of the mitochondrial-specific rhodacyanine dye analog MKT 077.

2000 • 100 citations

The Cleavage of Akt/Protein Kinase B by Death Receptor Signaling Is an Important Event in Detachment-induced Apoptosis

2001 • 100 citations

Phase I and II clinical trials of trastuzumab

2001 • 88 citations

AA1, a newly synthesized monovalent lipophilic cation, expresses potent in vivo antitumor activity.

1994 • 84 citations

Revertants of v-fos-transformed fibroblasts have mutations in cellular genes essential for transformation by other oncogenes

1987 • 82 citations

Identification of genes showing differential expression in antisense K-ras-transduced pancreatic cancer cells with suppressed tumorigenicity.

1999 • 53 citations

Bcl-2: B Cell Life, Death and Neoplasia

1990 • 51 citations

New Combinations with Herceptin<sup>®</sup> in Metastatic Breast Cancer

2001 • 47 citations

Caspase-dependent Cleavage of ErbB-2 by Geldanamycin and Staurosporin

2001 • 44 citations

Cytotoxic effect of thiacarbocyanine dyes on human colon carcinoma cells and inhibition of bovine heart mitochondrial NADH-ubiquinone reductase activity via a rotenone-type mechanism by two of the dyes

1993 • 34 citations

MKT-077, localized lipophilic cation: antitumor activity against human tumor xenografts serially transplanted into nude mice.

1998 • 32 citations

Inhibition of bovine heart mitochondrial and Paracoccus denitrificans NADH----ubiquinone reductase by dequalinium chloride and three structurally related quinolinium compounds.

1989 • 18 citations

Ethyl-nitrosourea transformed astrocytes exhibit mitochondrial membrane hyperpolarization and constrained apoptosis.

1999 • 15 citations

Epidermal Growth Factor Receptor as a Target: Recent Developments in the Search for Effective New Anti-Cancer Agents

2001 • 13 citations

Active cell membrane mechanisms involved in the exclusion of RH 123 allow distinction between normal and tumoral cells

1994 • 6 citations