The Proapoptotic Gene SIVA Is a Direct Transcriptional Target for the Tumor Suppressors p53 and E2F1

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

p53 Has a Direct Apoptogenic Role at the Mitochondria

2003 • 1,735 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes

1992 • 1,514 citations

The p53 pathway

1999 • 1,322 citations

Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics

1999 • 928 citations

Distinct Neural Stem Cells Proliferate in Response to EGF and FGF in the Developing Mouse Telencephalon

1999 • 807 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Apaf-1 is a transcriptional target for E2F and p53

2001 • 590 citations

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

2002 • 485 citations

CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons

1999 • 435 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons

2002 • 416 citations

Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons

1999 • 384 citations

Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

1996 • 378 citations

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

1998 • 357 citations

Bax Involvement in p53-Mediated Neuronal Cell Death

1998 • 337 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

Up-regulation of Bcl-2 Homology 3 (BH3)-only Proteins by E2F1 Mediates Apoptosis

2004 • 316 citations

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide

2001 • 315 citations

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

1996 • 299 citations

CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein

1997 • 294 citations

Cyclin-dependent kinases as a therapeutic target for stroke

2000 • 276 citations

Cyclin-dependent Kinases Participate in Death of Neurons Evoked by DNA-damaging Agents

1998 • 264 citations

p53 induction is associated with neuronal damage in the central nervous system.

1994 • 262 citations

Introduction to the E2F Family: Protein Structure and Gene Regulation

1996 • 249 citations

Evidence for p53-Mediated Modulation of Neuronal Viability

1996 • 247 citations

The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family.

1991 • 245 citations

Involvement of Cell Cycle Elements, Cyclin-dependent Kinases, pRb, and E2F·DP, in B-amyloid-induced Neuronal Death

1999 • 242 citations

Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation.

1995 • 239 citations

Transcriptional activation by p53 correlates with suppression of growth but not transformation

1994 • 237 citations

E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3

2000 • 203 citations

Neuronal life and death: an essential role for the p53 family

2000 • 201 citations

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death

2001 • 190 citations

Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.

1999 • 186 citations

p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats.

1994 • 183 citations

Overexpression of E2F‐1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo

1998 • 167 citations

Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death

1998 • 163 citations

Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs.

1996 • 154 citations

Hypoxia-Inducible Factor-1α Mediates Hypoxia-Induced Delayed Neuronal Death That Involves p53

1999 • 153 citations

Involvement of Retinoblastoma Family Members and E2F/DP Complexes in the Death of Neurons Evoked by DNA Damage

2000 • 151 citations

Induction and Modulation of Cerebellar Granule Neuron Death by E2F-1

2000 • 143 citations

Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G₁

1996 • 139 citations

CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses: enhancement of plasma cell differentiation by CD27 signaling.

1997 • 136 citations

Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons.

1996 • 125 citations

CD27 is a signal-transducing molecule involved in CD45RA+ naive T cell costimulation.

1994 • 120 citations

Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types

2003 • 118 citations

Evidence for involvement of Bax and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons

1998 • 112 citations

Contribution of p53-Dependent Caspase Activation to Neuronal Cell Death Declines with Neuronal Maturation

1999 • 111 citations

E2F1 Induces Phosphorylation of p53 That Is Coincident with p53 Accumulation and Apoptosis

2002 • 110 citations

Novel Function of the Cyclin A Binding Site of E2F in Regulating p53-Induced Apoptosis in Response to DNA Damage

2002 • 109 citations

The Transcription Factor E2F1 Modulates Apoptosis of Neurons

2000 • 105 citations

Definition of the p53 Functional Domains Necessary for Inducing Apoptosis

2000 • 104 citations

GITR interacts with the pro-apoptotic protein Siva and induces apoptosis

2002 • 98 citations

Inhibition of Cyclin-Dependent Kinases Improves CA1 Neuronal Survival and Behavioral Performance after Global Ischemia in the Rat

2002 • 97 citations

Involvement of Caspase 3 in Apoptotic Death of Cortical Neurons Evoked by DNA Damage

2000 • 91 citations

Hippocampal Myc and p53 expression following transient global ischemia

1998 • 85 citations

Siva-1 and an Alternative Splice Form Lacking the Death Domain, Siva-2, Similarly Induce Apoptosis in T Lymphocytes via a Caspase-Dependent Mitochondrial Pathway

2004 • 84 citations

Siva-1 binds to and inhibits BCL-X_L-mediated protection against UV radiation-induced apoptosis

2002 • 81 citations

Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: a pharmacogenomic study.

2003 • 80 citations

The ARG Tyrosine Kinase Interacts with Siva-1 in the Apoptotic Response to Oxidative Stress

2001 • 66 citations

Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family

1993 • 62 citations

Role of CD27 in T cell immune response. Analysis by recombinant soluble CD27.

1994 • 62 citations

Decreased brain infarct following focal ischemia in mice lacking the transcription factor E2F1

1999 • 59 citations

Attenuation of neurotoxicity in cortical cultures and hippocampal slices from E2F1 knockout mice

2001 • 55 citations

Increase in p53 protein expression following cortical infarction in the spontaneously hypertensive rat

1999 • 51 citations

Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons

2000 • 49 citations

Murine Siva-1 and Siva-2, alternate splice forms of the mouse Siva gene, both bind to CD27 but differentially transduce apoptosis

1999 • 47 citations

Gene expression analysis in colorectal cancer using practical DNA array filter

2001 • 35 citations