Autophagy in cell death: an innocent convict?

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

2015 • 15,801 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Development by Self-Digestion

2004 • 3,562 citations

Autophagy as a Regulated Pathway of Cellular Degradation

2000 • 3,453 citations

Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

2005 • 3,368 citations

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1999 • 3,194 citations

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

1997 • 2,762 citations

The role of autophagy during the early neonatal starvation period

2004 • 2,753 citations

Autophagy in Health and Disease: A Double-Edged Sword

2004 • 2,470 citations

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

2004 • 2,265 citations

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

2003 • 2,136 citations

Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

2004 • 2,135 citations

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

2003 • 2,041 citations

Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy

2004 • 1,870 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae

1993 • 1,649 citations

Inhibition of Macroautophagy Triggers Apoptosis

2005 • 1,581 citations

Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis

2005 • 1,448 citations

Autophagy as a cell death and tumor suppressor mechanism

2004 • 1,375 citations

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

2003 • 1,354 citations

Death by design: apoptosis, necrosis and autophagy

2004 • 1,330 citations

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

2004 • 1,322 citations

3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

1982 • 1,313 citations

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

2003 • 1,214 citations

Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8

2004 • 1,204 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells

2000 • 1,125 citations

Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein

1998 • 1,091 citations

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

2002 • 1,076 citations

Autophagy Defends Cells Against Invading Group A Streptococcus

2004 • 1,042 citations

Progression From Compensated Hypertrophy to Failure in the Pressure-Overloaded Human Heart

2003 • 1,023 citations

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1997 • 1,016 citations

Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat Body

2004 • 927 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

The Phosphatidylinositol 3‐Kinase Inhibitors Wortmannin and LY294002 Inhibit Autophagy in Isolated Rat Hepatocytes

1997 • 828 citations

Autophagy Regulates Programmed Cell Death during the Plant Innate Immune Response

2005 • 814 citations

Escape of Intracellular Shigella from Autophagy

2004 • 798 citations

The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini

2002 • 763 citations

Cloning and Genomic Organization of Beclin 1, a Candidate Tumor Suppressor Gene on Chromosome 17q21

1999 • 761 citations

Autophagy in metazoans: cell survival in the land of plenty

2005 • 752 citations

The morphology of various types of cell death in prenatal tissues

1973 • 716 citations

Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway

2001 • 705 citations

Apoptosis, autophagy, and more

2004 • 678 citations

Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and ‘aggresomes’ during oxidative stress, aging, and disease

2004 • 630 citations

BNIP3 and Genetic Control of Necrosis-Like Cell Death through the Mitochondrial Permeability Transition Pore

2000 • 605 citations

Regulation and role of autophagy in mammalian cells

2004 • 602 citations

The autophagosomal–lysosomal compartment in programmed cell death

2001 • 599 citations

The mitochondrial permeability transition initiates autophagy in rat hepatocytes

2001 • 596 citations

The APG8/12-activating Enzyme APG7 Is Required for Proper Nutrient Recycling and Senescence in Arabidopsis thaliana

2002 • 578 citations

Leaf Senescence and Starvation-Induced Chlorosis Are Accelerated by the Disruption of an Arabidopsis Autophagy Gene

2002 • 577 citations

Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell Death

2001 • 570 citations

Induction of autophagic cell death in malignant glioma cells by arsenic trioxide.

2003 • 546 citations

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

2001 • 546 citations

Huntingtin Expression Stimulates Endosomal–Lysosomal Activity, Endosome Tubulation, and Autophagy

2000 • 522 citations

Essential Roles of Atg5 and FADD in Autophagic Cell Death

2005 • 522 citations

Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy

1996 • 508 citations

DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death

2002 • 467 citations

Programmed Autophagy in the Drosophila Fat Body Is Induced by Ecdysone through Regulation of the PI3K Pathway

2004 • 462 citations

Targeting mTOR signaling for cancer therapy

2003 • 439 citations

Cellular autophagy: surrender, avoidance and subversion by microorganisms

2004 • 435 citations

Autophagy Is Activated by Apoptotic Signalling in Sympathetic Neurons: An Alternative Mechanism of Death Execution

1999 • 424 citations

Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and Up-regulation of Beclin 1

2004 • 422 citations

Eukaryotic Proteasomes Cannot Digest Polyglutamine Sequences and Release Them during Degradation of Polyglutamine-Containing Proteins

2004 • 409 citations

Uth1p Is Involved in the Autophagic Degradation of Mitochondria

2004 • 406 citations

Pivotal Role of the Cell Death Factor BNIP3 in Ceramide-Induced Autophagic Cell Death in Malignant Glioma Cells

2004 • 398 citations

Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3

2004 • 385 citations

Resveratrol-induced Autophagocytosis in Ovarian Cancer Cells

2004 • 375 citations

Autophagy: a barrier or an adaptive response to cancer

2003 • 364 citations

Steroid regulation of autophagic programmed cell death during development

2001 • 330 citations

The role of α-synuclein in Parkinson's disease: insights from animal models

2003 • 318 citations

Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments

2000 • 311 citations

A Novel Protein Complex Linking the δ2 Glutamate Receptor and Autophagy

2002 • 295 citations

Programmed cell death in Dictyostelium

1994 • 284 citations

Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for β-amyloid peptide over-production and localization in Alzheimer’s disease

2004 • 273 citations

Autophagy regulates the processing of amino terminal huntingtin fragments

2003 • 250 citations

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro

2004 • 238 citations

Autophagic Cell Death and Its Execution by Lysosomal Cathepsins.

2001 • 234 citations

Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis

2001 • 231 citations

Macroautophagy Is Required for Multicellular Development of the Social Amoeba Dictyostelium discoideum

2003 • 216 citations

Inhibition of autophagy abrogates tumour necrosis factor α induced apoptosis in human T‐lymphoblastic leukaemic cells

1997 • 214 citations

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

2003 • 213 citations

ASalmonellaprotein causes macrophage cell death by inducing autophagy

2003 • 212 citations

A SAGE Approach to Discovery of Genes Involved in Autophagic Cell Death

2003 • 211 citations

Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease?

2002 • 207 citations

Genome-Wide Analyses of Steroid- and Radiation-Triggered Programmed Cell Death in Drosophila

2003 • 206 citations

Steroid Regulation of Midgut Cell Death during Drosophila Development

2002 • 206 citations

Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells

2000 • 180 citations

Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides

2003 • 159 citations

N‐methyl‐<scp>d</scp>‐aspartate‐triggered neuronal death in organotypic hippocampal cultures is endocytic, autophagic and mediated by the c‐Jun N‐terminal kinase pathway

2003 • 154 citations

Mitochondrial Membrane Permeabilization during the Apoptotic Process

1999 • 147 citations

Dictyostelium Macroautophagy Mutants Vary in the Severity of Their Developmental Defects

2004 • 138 citations

Mutations in the Novel Membrane Protein Spinster Interfere with Programmed Cell Death and Cause Neural Degeneration inDrosophila melanogaster

2001 • 133 citations

Rab7 Prevents Growth Factor-Independent Survival by Inhibiting Cell-Autonomous Nutrient Transporter Expression

2003 • 127 citations

Role of the autophagic‐lysosomal system on low potassium‐induced apoptosis in cultured cerebellar granule cells

2005 • 126 citations

Neuronal cell death in transmissible spongiform encephalopathies (prion diseases) revisited: from apoptosis to autophagy

2004 • 115 citations

Selective Inactivation of a Fas-associated Death Domain Protein (FADD)-dependent Apoptosis and Autophagy Pathway in Immortal Epithelial Cells

2005 • 107 citations

The Drosophila homolog of Aut1 is essential for autophagy and development

2003 • 102 citations

Reduced autophagic activity, improved protein balance and enhanced in vitro survival of hepatocytes isolated from carcinogen-treated rats

1985 • 99 citations

HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death

2003 • 95 citations

Diphtheria Toxin-induced Autophagic Cardiomyocyte Death Plays a Pathogenic Role in Mouse Model of Heart Failure

2004 • 93 citations

Chloroquine-Induced Neuronal Cell Death Is p53 and Bcl-2 Family-Dependent But Caspase-Independent

2001 • 91 citations

Autophagy Gene Disruption Reveals a Non-vacuolar Cell Death Pathway in Dictyostelium

2004 • 88 citations

Exploiting different ways to die: Figure 1.

2004 • 87 citations

Endostatin induces autophagic cell death in EAhy926 human endothelial cells.

2003 • 85 citations

The product of the UTH1 gene, required for Bax‐induced cell death in yeast, is involved in the response to rapamycin

2003 • 78 citations

Alternative Programs of Cell Death in Developing Retinal Tissue

2003 • 72 citations

An Ultrastructural and Immunohistochemical Study of PC12 Cells During Apoptosis Induced by Serum Deprivation with Special Reference to Autophagy and Lysosomal Cathepsins.

1998 • 71 citations

Programmed cell death during metamorphosis in the blow-flyCalliphora vomitoria

1996 • 66 citations

STAUROSPORINE‐INDUCED CELL DEATH IN TETRAHYMENA THERMOPHILA HAS MIXED CHARACTERISTICS OF BOTH APOPTOTIC AND AUTOPHAGIC DEGENERATION

1998 • 60 citations

Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells.

2000 • 56 citations

Autophagic and apoptotic features during programmed cell death in the fat body of the tobacco hornworm (Manduca sexta)

2004 • 46 citations

Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues

2002 • 45 citations

Growth Factor Deprivation Induces an Alternative Non-apoptotic Death Mechanism That Is Inhibited by Bcl2 in Cells Derived from Neural Precursor Cells

2003 • 44 citations

Steroid‐triggered programmed cell death of a motoneuron is autophagic and involves structural changes in mitochondria

2003 • 41 citations

Modulation of Host Gene Expression and Innate Immunity by Viruses

2005 • 35 citations

Acid phosphatase activity in the larval salivary glands of developing Drosophila melanogaster.

1993 • 29 citations

5-Fluorouracil induces autophagic degeneration in rat oral keratinocytes

2001 • 20 citations

Signaling Pathways in Mammalian Autophagy

2003 • 17 citations

Quantitative studies of cytochemical and cytological changes during cell death in the larval fat body of Drosophila melanogaster

1973 • 17 citations

8 Tumour necrosis factor induced autophagy and mitochondrial morphological abnormalities are mediated by TNFR-I and/or TNFR-II and do not invariably lead to cell death

1998 • 15 citations

Digesting Oneself and Digesting Microbes

2005 • 10 citations

Degeneration of moulting glands in male crickets

1998 • 10 citations