Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria

Surfing the p53 network

2000 • 6,487 citations

Probiotics in man and animals

1989 • 4,002 citations

Mitochondrial control of cell death

2000 • 3,098 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

Mitochondrion as a Novel Target of Anticancer Chemotherapy

2000 • 536 citations

The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

2000 • 449 citations

A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2

1999 • 422 citations

Apoptosis in colorectal tumour cells: Induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate

1995 • 411 citations

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

1998 • 372 citations

Role of short-chain fatty acids in the prevention of colorectal cancer

1995 • 349 citations

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

2000 • 336 citations

Arsenite Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

1999 • 307 citations

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

2000 • 286 citations

Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

2000 • 269 citations

Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2

2001 • 269 citations

Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells.

1998 • 244 citations

Diet and Cancer

2000 • 244 citations

Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

2000 • 236 citations

Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator

2000 • 228 citations

Only fibres promoting a stable butyrate producing colonic ecosystem decrease the rate of aberrant crypt foci in rats

2001 • 222 citations

Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

1999 • 211 citations

Mechanisms and experimental and epidemiological evidence relating dietary fibre (non-starch polysaccharides) and starch to protection against large bowel cancer

1990 • 204 citations

GD3 ganglioside directly targets mitochondria in a bcl‐2‐controlled fashion

2000 • 189 citations

Assessment of adhesion properties of novel probiotic strains to human intestinal mucus

2001 • 184 citations

Short-chain fatty acid-initiated cell cycle arrest and apoptosis of colonic epithelial cells is linked to mitochondrial function.

1997 • 181 citations

Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).

1998 • 158 citations

Apoptosis induced by the histone deacetylase inhibitor sodium butyrate in human leukemic lymphoblasts

1999 • 132 citations

The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.

1999 • 128 citations

Fatty acid‐induced uncoupling of oxidative phosphorylation is partly due to opening of the mitochondrial permeability transition pore

1998 • 120 citations

Chemical, physical and enzymatic pre-treatments of probiotic lactobacilli alter their adhesion to human intestinal mucus glycoproteins

2000 • 117 citations

Fatty acid‐promoted mitochondrial permeability transition by membrane depolarization and binding to the ADP/ATP carrier

1997 • 108 citations

Apoptosis Cascade Proteins Are Regulated In Vivo by High Intracolonic Butyrate Concentration: Correlation With Colon Cancer Inhibition

2001 • 107 citations

Changes in Protein Synthesis and Morphology during Acid Adaptation of Propionibacterium freudenreichii

2001 • 105 citations

bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis

1997 • 100 citations

Effect of Propionibacteria Supplementation on Fecal Bifidobacteria and Segmental Colonic Transit Time in Healthy Human Subjects

1999 • 90 citations

Involvement of p21Waf1/Cip1 and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate

2000 • 88 citations

Human ileostomy glycoproteins as a model for small intestinal mucus to investigate adhesion of probiotics

1999 • 83 citations

Palmitate induces apoptosis via a direct effect on mitochondria.

1999 • 79 citations

Apoptosis induction by the photosensitizer verteporfin: identification of mitochondrial adenine nucleotide translocator as a critical target.

2001 • 77 citations

Effects of amiloride and ouabain on short‐chain fatty acid transport in guinea‐pig large intestine.

1993 • 60 citations

Acid stress susceptibility and acid adaptation of Propionibacterium freudenreichii subsp. shermanii

2000 • 58 citations

Photomodification of Mitochondrial Proteins by Azido Fatty Acids and Its Effect on Mitochondrial Energetics

1996 • 45 citations

MT-21 is a synthetic apoptosis inducer that directly induces cytochrome c release from mitochondria.

2000 • 43 citations

Deoxycholic acid and SCFA-induced apoptosis in the human tumor cell-line HT-29 and possible mechanisms

1997 • 34 citations

Propionibacterium acnes induces acute TNFα-mediated apoptosis of hepatocytes followed by inflammatory T-cell-mediated granulomatous hepatitis in mice

1999 • 19 citations

[The protective effect of cyclosporine A, carnitine, and Mg(2+) with ADP during calcium(2+)-dependent permeabilization of mitochondria by fatty acids and activation of NADH oxidation by an external pathway].

1993 • 4 citations