BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

Mitochondria and Apoptosis

1998 • 8,909 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein

1988 • 1,488 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent

1996 • 1,047 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Role of Bcl‐2 family proteins in apoptosis: apoptosomes or mitochondria?

1998 • 705 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

1997 • 489 citations

Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling

1999 • 473 citations

Structure-Function Analysis of Bcl-2 Protein

1995 • 419 citations

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

1998 • 414 citations

Solution Structure of the Proapoptotic Molecule BID

1999 • 387 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors.

1996 • 300 citations

Voltage gating in the mitochondrial channel, VDAC

1989 • 296 citations

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

1998 • 237 citations

Ion Channel Activity of the BH3 Only Bcl-2 Family Member, BID

1999 • 195 citations

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.

1994 • 186 citations

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

1999 • 157 citations

Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL

1998 • 129 citations

Functional Dissection of the Human Bcl2 Protein: Sequence Requirements for Inhibition of Apoptosis

1996 • 126 citations

EFFECTS OF TRANSFECTED COMPLEMENT REGULATORY PROTEINS, MCP, DAF, AND MCP/DAF HYBRID, ON COMPLEMENT-MEDIATED SWINE ENDOTHELIAL CELL LYSIS

1994 • 114 citations

NH2-terminal BH4 Domain of Bcl-2 Is Functional for Heterodimerization with Bax and Inhibition of Apoptosis

1999 • 93 citations

Evidence for α-Helical Conformation of an Essential N-terminal Region in the Human Bcl2 Protein

1996 • 50 citations

Neuroprotection with Bcl-220–34 peptide against trauma

1998 • 22 citations

Binding of a synthetic targeting peptide to a mitochondrial channel protein

1992 • 15 citations