The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

The expanding role of mitochondria in apoptosis.

2001 • 2,377 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

2002 • 1,015 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

ULTRASTRUCTURAL BASES FOR METABOLICALLY LINKED MECHANICAL ACTIVITY IN MITOCHONDRIA

1966 • 947 citations

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

2002 • 803 citations

Liver Tumor Development

2003 • 466 citations

Cardiolipin provides specificity for targeting of tBid to mitochondria

2000 • 462 citations

Bid-induced Cytochrome c Release Is Mediated by a Pathway Independent of Mitochondrial Permeability Transition Pore and Bax

2000 • 179 citations

The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites.

2001 • 141 citations

Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling

2001 • 137 citations

Two pathways for tBID‐induced cytochrome c release from rat brain mitochondria: BAK‐ versus BAX‐dependence

2002 • 61 citations