Paclitaxel Affects Cytosolic Calcium Signals by Opening the Mitochondrial Permeability Transition Pore

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

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Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

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Decoding of cytosolic calcium oscillations in the mitochondria

1995 • 1,090 citations

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations.

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J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

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Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

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Bcl‐2 family: Life‐or‐death switch

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Bcl2 is the guardian of microtubule integrity.

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Mitochondria as all‐round players of the calcium game

2000 • 556 citations

Taxol Suppresses Dynamics of Individual Microtubules in Living Human Tumor Cells

1999 • 534 citations

Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

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Local and global cytosolic Ca2+ oscillations in exocrine cells evoked by agonists and inositol trisphosphate

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The Mitochondrial Permeability Transition, Release of Cytochrome c and Cell Death

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Phase I clinical and pharmacokinetic study of taxol.

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Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca2+ signals

1999 • 362 citations

Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells

2001 • 360 citations

Molecular effects of paclitaxel: Myths and reality (a critical review)

1999 • 356 citations

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1999 • 338 citations

Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport

2001 • 312 citations

Calcium and Hormone Action

1994 • 307 citations

Mitochondria Exert a Negative Feedback on the Propagation of Intracellular Ca2+ Waves in Rat Cortical Astrocytes

1999 • 295 citations

Functional Consequences of the Sustained or Transient Activation by Bax of the Mitochondrial Permeability Transition Pore

1999 • 295 citations

Polarized Expression of Ca2+ Channels in Pancreatic and Salivary Gland Cells

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Paclitaxel-induced neuropathy

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Screening of a library of phage-displayed peptides identifies human Bcl-2 as a taxol-binding protein 1 1Edited by I. A. Wilson

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Ca2+ Homeostasis in the Agonist-sensitive Internal Store: Functional Interactions Between Mitochondria and the ER Measured In Situ in Intact Cells

1998 • 185 citations

Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells'.

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The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis.

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Construction of the endoplasmic reticulum.

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Luminal communication between intracellular calcium stores modulated by GTP and the cytoskeleton.

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Cyclosporin A Inhibits Inositol 1,4,5-Trisphosphate-dependent Ca2+ Signals by Enhancing Ca2+ Uptake into the Endoplasmic Reticulum and Mitochondria

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Structural Determinants of Adenophostin A Activity at Inositol Trisphosphate Receptors

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Cellular Immune Profile of Patients With Advanced Cancer Before and After Taxane Treatment

2000 • 52 citations

Cytoplasmic dynein and dynactin as likely candidates for microtubule-dependent apical targeting of pancreatic zymogen granules

1999 • 40 citations

The role of Ca²⁺ feedback in shaping InsP₃‐evoked Ca²⁺ signals in mouse pancreatic acinar cells

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Microtubules Regulate Local Ca2+ Spiking in Secretory Epithelial Cells

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The Endoplasmic Reticulum Can Act as a Functional Ca2+ Store in All Subcellular Regions of the Pancreatic Acinar Cell

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A Bimodal Pattern of InsP3-Evoked Elementary Ca2+ Signals in Pancreatic Acinar Cells

2000 • 16 citations

The properties of the secretagogue-evoked chloride current in mouse pancreatic acinar cells

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R&D budget: Growth in Hard Times

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