An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic Bcl-2 in human dopaminergic SH-SY5Y cells

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Bcl‐2 family: Life‐or‐death switch

2000 • 665 citations

Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFκB Activation in Primary Hippocampal Neurons

1999 • 552 citations

Increased Caspase 3 and Bax Immunoreactivity Accompany Nuclear GAPDH Translocation and Neuronal Apoptosis in Parkinson's Disease

2000 • 402 citations

Transfection‐enforced Bcl‐2 overexpression and an anti‐Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde‐3‐phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N‐methyl(R)salsolinol

2001 • 168 citations

Neuroprotective effect of rasagiline, a selective monoamine oxidase-B inhibitor, against closed head injury in the mouse

1999 • 141 citations

Neuroprotective Action of Cycloheximide Involves Induction of Bcl-2 and Antioxidant Pathways

1997 • 122 citations

Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor

1998 • 105 citations

Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022

2000 • 94 citations

Enantio-specific induction of apoptosis by an endogenous neurotoxin, N -methyl( R )salsolinol, in dopaminergic SH-SY5Y cells: suppression of apoptosis by N -(2-heptyl)- N -methylpropargylamine

2001 • 58 citations

Future of neuroprotection in Parkinson's disease

2001 • 46 citations

Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3

1999 • 46 citations