Activated Mitofusin 2 Signals Mitochondrial Fusion, Interferes with Bax Activation, and Reduces Susceptibility to Radical Induced Depolarization

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

ras GENES

1987 • 3,818 citations

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

2003 • 2,349 citations

The Guanine Nucleotide-Binding Switch in Three Dimensions

2001 • 1,779 citations

Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells

2001 • 1,739 citations

The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis

2001 • 1,663 citations

Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A

2004 • 1,505 citations

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

1992 • 1,342 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

OPA1 requires mitofusin 1 to promote mitochondrial fusion

2004 • 1,158 citations

Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

2003 • 1,088 citations

Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis

2004 • 995 citations

Control of mitochondrial morphology by a human mitofusin

2001 • 957 citations

Structural Basis of Mitochondrial Tethering by Mitofusin Complexes

2004 • 843 citations

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

2002 • 801 citations

Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism

2003 • 788 citations

The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1

2003 • 778 citations

Dynamics of mitochondrial morphology in healthy cells and during apoptosis

2003 • 728 citations

A Human Dynamin-related Protein Controls the Distribution of Mitochondria

1998 • 711 citations

Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity

2004 • 662 citations

Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by Mitofusins

2002 • 633 citations

hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery

2003 • 615 citations

Mitochondria are morphologically and functionally heterogeneous within cells

2002 • 551 citations

Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo

2002 • 529 citations

Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

2003 • 509 citations

Genetic Basis of Mitochondrial Function and Morphology inSaccharomyces cerevisiae

2002 • 448 citations

Mitochondrial fission in apoptosis, neurodegeneration and aging

2003 • 421 citations

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

2004 • 420 citations

Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells

2003 • 420 citations

Two Mitofusin Proteins, Mammalian Homologues of FZO, with Distinct Functions Are Both Required for Mitochondrial Fusion

2003 • 412 citations

Mitochondrial membrane remodelling regulated by a conserved rhomboid protease

2003 • 388 citations

Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA

2003 • 377 citations

Sumo1 Conjugates Mitochondrial Substrates and Participates in Mitochondrial Fission

2004 • 345 citations

Dysregulation of HSG triggers vascular proliferative disorders

2004 • 341 citations

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

1996 • 322 citations

Fzo1, a Protein Involved in Mitochondrial Fusion, Inhibits Apoptosis

2004 • 321 citations

Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology

2004 • 320 citations

Mammalian Dynamin-like Protein DLP1 Tubulates Membranes

2001 • 282 citations

A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast

2001 • 271 citations

Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore

1999 • 252 citations

Mitochondrial GTPase mitofusin 2 mutation in Charcot?Marie?Tooth neuropathy type 2A

2004 • 246 citations

The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion

2003 • 245 citations

UGO1 Encodes an Outer Membrane Protein Required for Mitochondrial Fusion

2001 • 242 citations

Ugo1p Links the Fzo1p and Mgm1p GTPases for Mitochondrial Fusion

2004 • 186 citations

Connection of the Mitochondrial Outer and Inner Membranes by Fzo1 Is Critical for Organellar Fusion

2001 • 155 citations

Mdm30 Is an F-Box Protein Required for Maintenance of Fusion-competent Mitochondria in Yeast

2003 • 138 citations

Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion

2003 • 135 citations

Electrical coupling and plasticity of the mitochondrial network

2000 • 118 citations

Kinetics of Interaction of Rab5 and Rab7 with Nucleotides and Magnesium Ions

1996 • 116 citations

Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

1993 • 96 citations

Interferon-induced MxA Protein.

1995 • 71 citations

X-ray Crystal Structure Analysis of the Catalytic Domain of the Oncogene Product p21H-rasComplexed with Caged GTP and Mant dGppNHp

1995 • 68 citations

Molecular Dynamics Simulations of Gly-12→Val Mutant of p21 : Dynamic Inhibition Mechanism

2001 • 43 citations

[14] Purification of EEA1 from bovine brain cytosol using Rab5 affinity chromatography and activity assays

2001 • 11 citations