Apoptosis induction by the photosensitizer verteporfin: identification of mitochondrial adenine nucleotide translocator as a critical target.

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Photodynamic Therapy

1988 • 4,275 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

1984 • 1,761 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.

1992 • 692 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

Mitochondrion as a Novel Target of Anticancer Chemotherapy

2000 • 536 citations

Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

1999 • 496 citations

The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

2000 • 449 citations

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

2000 • 415 citations

Low molecular weight heparins: prophylaxis of venous thromboembolism in surgical patients.

1997 • 399 citations

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

1998 • 372 citations

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

2000 • 336 citations

The Role of Reactive Oxygen Species in Mitochondrial Permeability Transition

1997 • 317 citations

Arsenite Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

1999 • 307 citations

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

2000 • 286 citations

Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells.

1998 • 244 citations

Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

1999 • 211 citations

Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands.

1993 • 198 citations

Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy

1998 • 189 citations

Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage

1996 • 186 citations

Oncogenic potential of bcl-2 demonstrated by gene transfer

1988 • 180 citations

Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).

1998 • 158 citations

The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.

1999 • 128 citations

Release of Cytochrome c, Bax Migration, Bid Cleavage, and Activation of Caspases 2, 3, 6, 7, 8, and 9 during Endothelial Cell Apoptosis

1999 • 106 citations

Photodynamic Tumor Therapy: Mitochondrial Benzodiazepine Receptors as a Therapeutic Target

1998 • 101 citations

Acidic pH Promotes Dimerization of Bcl-2 Family Proteins

1998 • 87 citations

Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy

1998 • 82 citations

Human Immunodeficiency Virus Induces a Dual Regulation of Bcl-2, Resulting in Persistent Infection of CD4⁺T- or Monocytic Cell Lines

1998 • 74 citations

Early release of mitochondrial cytochrome c and expression of mitochondrial epitope 7A6 with a porphyrin-derived photosensitizer: Bcl-2 and Bcl-xL overexpression do not prevent early mitochondrial events but still depress caspase activity.

1999 • 71 citations

Overexpression of Bcl‐X_L prevents caspase‐3‐mediated activation of DNA fragmentation factor (DFF) produced by treatment with the photochemotherapeutic agent BPD‐MA

1998 • 47 citations

Ex vivo photodynamic purging in chronic myelogenous leukaemia and other neoplasias with rhodamine derivatives

1999 • 32 citations

Porphyrin-mediated photosensitization - taking the apoptosis fast lane.

2000 • 28 citations