Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

p53 function and dysfunction

1992 • 1,918 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

1993 • 786 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

1993 • 711 citations

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

1994 • 664 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

1994 • 482 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Small Subgroup of Aggressive, Highly Proliferative Prostatic Carcinomas Defined by p53 Accumulation

1992 • 317 citations

Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma

1992 • 233 citations

c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle.

1994 • 210 citations

Reversal of Chemoresistance of Lymphoma Cells by Antisense-Mediated Reduction ofbcl-2 Gene Expression

1994 • 190 citations

Mammalian p53 can function as a transcription factor in yeast

1992 • 182 citations

Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line.

1993 • 177 citations

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.

1994 • 168 citations

Bovine papillomavirus transcriptional regulation: localization of the E2-responsive elements of the long control region

1987 • 160 citations

The helix-loop-helix/leucine repeat transcription factor USF can be functionally regulated in a redox-dependent manner.

1992 • 127 citations

Investigations of Antisense Oligonucleotides Targeted Againstbcl-2RNAs

1993 • 95 citations

Mutant p53 increases radioresistance in rat embryo fibroblasts simultaneously transfected with HPV16-E7 and/or activated H-ras.

1994 • 83 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system

1995 • 33 citations