The many shapes of mitochondrial death

Cell Death

2004 • 4,599 citations

Regulation of cell death: the calcium–apoptosis link

2003 • 2,826 citations

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

2003 • 2,349 citations

Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells

2001 • 1,739 citations

The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis

2001 • 1,663 citations

Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A

2004 • 1,505 citations

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

2000 • 1,370 citations

The dynamin superfamily: universal membrane tubulation and fission molecules?

2004 • 1,329 citations

Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction

2005 • 1,270 citations

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

2000 • 1,269 citations

OPA1 requires mitofusin 1 to promote mitochondrial fusion

2004 • 1,158 citations

Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

2003 • 1,088 citations

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

2002 • 1,015 citations

Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis

2004 • 995 citations

Structural Basis of Mitochondrial Tethering by Mitofusin Complexes

2004 • 843 citations

The internal structure of mitochondria

2000 • 810 citations

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

2002 • 801 citations

Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism

2003 • 788 citations

The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1

2003 • 778 citations

Mitochondrial fission in apoptosis

2005 • 745 citations

Dnm1p Gtpase-Mediated Mitochondrial Fission Is a Multi-Step Process Requiring the Novel Integral Membrane Component Fis1p

2000 • 698 citations

Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity

2004 • 662 citations

C. elegans Dynamin-Related Protein DRP-1 Controls Severing of the Mitochondrial Outer Membrane

1999 • 638 citations

hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery

2003 • 615 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Mitochondria as all‐round players of the calcium game

2000 • 556 citations

Dnm1 forms spirals that are structurally tailored to fit mitochondria

2005 • 554 citations

Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons.

1995 • 533 citations

Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

2003 • 509 citations

The Machinery of Mitochondrial Inheritance and Behavior

1999 • 502 citations

Drp-1-Dependent Division of the Mitochondrial Network Blocks Intraorganellar Ca2+ Waves and Protects against Ca2+-Mediated Apoptosis

2004 • 466 citations

Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells

2000 • 462 citations

The inhibitors of apoptosis: there is more to life than Bcl2

2003 • 440 citations

Mitochondrial Fusion Intermediates Revealed in Vitro

2004 • 436 citations

Loss of the Intermembrane Space Protein Mgm1/OPA1 Induces Swelling and Localized Constrictions along the Lengths of Mitochondria

2004 • 433 citations

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

2004 • 420 citations

Bcl-2 decreases the free Ca ²⁺ concentration within the endoplasmic reticulum

2000 • 417 citations

The human dynamin‐related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter‐membrane space

2002 • 401 citations

Mutation spectrum and splicing variants in the OPA1 gene

2001 • 370 citations

Mitochondrial dynamics and division in budding yeast

2002 • 368 citations

Sumo1 Conjugates Mitochondrial Substrates and Participates in Mitochondrial Fission

2004 • 345 citations

Dysregulation of HSG triggers vascular proliferative disorders

2004 • 341 citations

Mitochondrial Function and Actin Regulate Dynamin-Related Protein 1-Dependent Mitochondrial Fission

2005 • 332 citations

Human deafness dystonia syndrome is a mitochondrial disease

1999 • 326 citations

Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis

2005 • 325 citations

Bax and Bak Promote Apoptosis by Modulating Endoplasmic Reticular and Mitochondrial Ca2+ Stores

2002 • 321 citations

Fzo1, a Protein Involved in Mitochondrial Fusion, Inhibits Apoptosis

2004 • 321 citations

DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

2005 • 306 citations

Mitochondrial fission proteins regulate programmed cell death in yeast

2004 • 295 citations

Activated Mitofusin 2 Signals Mitochondrial Fusion, Interferes with Bax Activation, and Reduces Susceptibility to Radical Induced Depolarization

2005 • 292 citations

Mammalian Dynamin-like Protein DLP1 Tubulates Membranes

2001 • 282 citations

Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis

2004 • 274 citations

Endophilin B1 is required for the maintenance of mitochondrial morphology

2004 • 253 citations

Release of OPA1 during Apoptosis Participates in the Rapid and Complete Release of Cytochrome c and Subsequent Mitochondrial Fragmentation

2005 • 247 citations

Three-dimensional reconstruction of dynamin in the constricted state

2001 • 243 citations

Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1

2004 • 242 citations

Propagation of the apoptotic signal by mitochondrial waves

2001 • 231 citations

Bax/Bak-Dependent Release of DDP/TIMM8a Promotes Drp1-Mediated Mitochondrial Fission and Mitoptosis during Programmed Cell Death

2005 • 221 citations

Calcineurin Inhibition of Dynamin I GTPase Activity Coupled to Nerve Terminal Depolarization

1994 • 215 citations

Expression and Genetic Analysis of XIAP-Associated Factor 1 (XAF1) in Cancer Cell Lines

2000 • 213 citations

Separate fusion of outer and inner mitochondrial membranes

2005 • 208 citations

Bax-mediated Ca2+ Mobilization Promotes Cytochrome c Release during Apoptosis

2002 • 199 citations

OPA1 (Kjer Type) Dominant Optic Atrophy: A Novel Mitochondrial Disease

2002 • 186 citations

OPA1 mutations in patients with autosomal dominant optic atrophy and evidence for semi-dominant inheritance

2001 • 185 citations

Mitochondrial fusion and fission in the control of apoptosis

2005 • 175 citations

Spectrum, frequency and penetrance of OPA1 mutations in dominant optic atrophy

2001 • 174 citations

Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1

2005 • 166 citations

OPA1 R445H mutation in optic atrophy associated with sensorineural deafness

2005 • 164 citations

The Solution Structure of Human Mitochondria Fission Protein Fis1 Reveals a Novel TPR-like Helix Bundle

2003 • 154 citations

Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria

2003 • 151 citations

eOPA1: An online database forOPA1mutations

2005 • 125 citations

Bcl-2 and Bax Exert Opposing Effects on Ca2+ Signaling, Which Do Not Depend on Their Putative Pore-forming Region

2004 • 112 citations

Bcl-X_Laffects Ca²⁺homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors

2002 • 100 citations

How mitochondria fuse

2005 • 98 citations

Deletion of the OPA1 gene in a dominant optic atrophy family: evidence that haploinsufficiency is the cause of disease

2002 • 79 citations

A frameshift mutation in exon 28 of the OPA1 gene explains the high prevalence of dominant optic atrophy in the Danish population: evidence for a founder effect

2001 • 75 citations

Self-regulated Cleavage of the Mitochondrial Intramembrane-cleaving Protease PARL Yields Pβ, a Nuclear-targeted Peptide

2004 • 65 citations

Proteins That Fuse and Fragment Mitochondria in Apoptosis: Con-Fissing a Deadly Con-Fusion?

2005 • 39 citations

Divide et impera: Ca2+ signals, mitochondrial fission and sensitization to apoptosis

2003 • 30 citations

A Novel Mutation of the OPA1 Gene in a Japanese Family with Optic Atrophy Type 1

2002 • 20 citations