Proteasome Inhibitors Trigger NOXA-Mediated Apoptosis in Melanoma and Myeloma Cells

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Two CD95 (APO-1/Fas) signaling pathways

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Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

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Endonuclease G is an apoptotic DNase when released from mitochondria

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

2002 • 1,617 citations

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

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BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

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Molecular sequelae of proteasome inhibition in human multiple myeloma cells

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Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

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Velcade®: U.S. FDA Approval for the Treatment of Multiple Myeloma Progressing on Prior Therapy

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Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341

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p53-dependent Induction of Apoptosis by Proteasome Inhibitors

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Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

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Focus on melanoma

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Integral role of Noxa in p53-mediated apoptotic response

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Protein Kinase Cδ Is Activated by Caspase-dependent Proteolysis during Ultraviolet Radiation-induced Apoptosis of Human Keratinocytes

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The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells

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Augmenting Chemosensitivity of Malignant Melanoma Tumors via Proteasome Inhibition

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The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis

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Bortezomib as a Potential Treatment for Prostate Cancer

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p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas

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Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53

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Favorable prognostic factors in recurrent and metastatic melanoma

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Activated N-ras contributes to the chemoresistance of human melanoma in severe combined immunodeficiency (SCID) mice by blocking apoptosis.

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Role of NF-κB Activity in Apoptotic Response of Keratinocytes Mediated by Interferon-γ, Tumor Necrosis Factor-α, and Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand

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Antagonizing XIAP-mediated caspase-3 inhibition

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Mutated N-ras upregulates Bcl-2 in human melanoma in vitro and in SCID mice

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Low‐dose UV‐radiation sensitizes keratinocytes to TRAIL‐induced apoptosis

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Pharmacodynamic Behavior of Liposomal Antisense Oligonucleotides Targeting Her-2/neu and Vascular Endothelial Growth Factor in an Ascitic MDA435/LCC6 Human Breast Cancer Model

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Pathways involved in proliferating, senescent and immortalized keratinocyte cell death mediated by two different TRAIL preparations

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Chemotherapy approaches to melanoma

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