Intrathecal cyclosporin prolongs survival of late-stage ALS mice

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

1997 • 792 citations

Cytochrome c: Can't Live with It—Can't Live without It

1997 • 768 citations

Carboxyfullerenes as neuroprotective agents

1997 • 724 citations

Massive Mitochondrial Degeneration in Motor Neurons Triggers the Onset of Amyotrophic Lateral Sclerosis in Mice Expressing a Mutant SOD1

1998 • 706 citations

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

2000 • 700 citations

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis

1999 • 680 citations

Benefit of vitamin E, riluzole, and gababapentin in a transgenic model of familial amyotrophic lateral sclerosis

1996 • 654 citations

Epidemiology of mutations in superoxide dismutase in amyotrophic lateal sclerosis

1997 • 517 citations

Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells.

1992 • 492 citations

Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1997 • 482 citations

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS)

1995 • 435 citations

Role for Bcl-x_Las an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

1997 • 397 citations

V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis

1999 • 379 citations

Cyclosporin A, But Not FK 506, Protects Mitochondria and Neurons against Hypoglycemic Damage and Implicates the Mitochondrial Permeability Transition in Cell Death

1998 • 372 citations

Protein Oxidative Damage in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1998 • 287 citations

An Intrathecal Bolus of Cyclosporin a before Injury Preserves Mitochondrial Integrity and Attenuates Axonal Disruption in Traumatic Brain Injury

1999 • 268 citations

Familial Amyotrophic Lateral Sclerosis

1967 • 235 citations

Cyclosporin A Significantly Ameliorates Cortical Damage Following Experimental Traumatic Brain Injury in Rodents

1999 • 233 citations

Mitochondrial Permeability Transition in the Central Nervous System: Induction by Calcium Cycling‐Dependent and ‐Independent Pathways

1997 • 231 citations

Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat

1995 • 230 citations

Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons.

1994 • 225 citations

Blockade of the Mitochondrial Permeability Transition Pore Diminishes Infarct Size in the Rat after Transient Middle Cerebral Artery Occlusion

1999 • 218 citations

Postinjury Cyclosporin A Administration Limits Axonal Damage and Disconnection in Traumatic Brain Injury

1999 • 202 citations

Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury

1999 • 199 citations

The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids

1999 • 193 citations

Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat

1998 • 190 citations

Continuous Infusion of Cyclosporin A Postinjury Significantly Ameliorates Cortical Damage Following Traumatic Brain Injury

2000 • 190 citations

The Copper Chelator d‐Penicillamine Delays Onset of Disease and Extends Survival in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1997 • 179 citations

Elevated “Hydroxyl Radical” Generation In Vivo in an Animal Model of Amyotrophic Lateral Sclerosis

1998 • 171 citations

Motor Neuron Disease (Amyotrophic Lateral Sclerosis)

1991 • 151 citations

Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia

1999 • 144 citations

Permeability of the Blood‐Brain Barrier to the Immunosuppressive Cyclic Peptide Cyclosporin A

1990 • 128 citations

Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia

1997 • 115 citations

Mechanisms for neuronal degeneration in amyotrophic lateral sclerosis and in models of motor neuron death (Review).

2000 • 103 citations

No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice

1999 • 102 citations

A Double-blind Study of the Effectiveness of Cyclosporine in Amyotrophic Lateral Sclerosis

1988 • 91 citations

Transgenic animal models of familial amyotrophic lateral sclerosis

1997 • 79 citations

P-Glycoprotein-Mediated Efflux Transport of Anticancer Drugs at the Blood-Brain Barrier

1998 • 68 citations

The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis

1999 • 63 citations

Molecular cloning and regional distribution of rat brain cyclophilin

1991 • 58 citations

The immunosuppressants cyclosporin A and FK506 equally ameliorate brain damage due to 30-min middle cerebral artery occlusion in hyperglycemic rats

1999 • 53 citations

Concentrations of Cyclosporin A and Its Metabolites in Human Tissues Postmortem

1991 • 48 citations

Immunointervention with cyclosporin A in autoimmune neurological disorders

1992 • 14 citations

New approaches to therapy of amyotrophic lateral sclerosis.

1998 • 4 citations