Signaling Mechanisms Regulating Endothelial Permeability

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

2003 • 7,170 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Regulated portals of entry into the cell

2003 • 3,642 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Circulating Endothelial Progenitor Cells, Vascular Function, and Cardiovascular Risk

2003 • 3,381 citations

Rab proteins as membrane organizers

2001 • 3,320 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

All About Albumin: Biochemistry, Genetics, and Medical Applications

1995 • 3,060 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

The immunopathogenesis of sepsis

2002 • 2,686 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Small GTP-Binding Proteins

2001 • 2,449 citations

MICROTUBULE POLYMERIZATION DYNAMICS

1997 • 2,442 citations

Thrombin signalling and protease-activated receptors

2000 • 2,383 citations

Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors

2000 • 2,286 citations

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

Thermodynamic analysis of the permeability of biological membranes to non-electrolytes

1958 • 2,157 citations

Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

2001 • 2,141 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Serum Albumin

1985 • 2,129 citations

On the Absorption of Fluids from the Connective Tissue Spaces

1896 • 2,075 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

Ca²⁺Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase

2003 • 1,913 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Rho and Rac Take Center Stage

2004 • 1,797 citations

Bioregulation of kinins: kallikreins, kininogens, and kininases.

1992 • 1,732 citations

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

2003 • 1,705 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Structure and Function of Lipopolysaccharide Binding Protein

1990 • 1,689 citations

Pharmacology of bradykinin and related kinins.

1983 • 1,674 citations

Basement membranes: structure, assembly and role in tumour angiogenesis

2003 • 1,652 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy

2002 • 1,549 citations

STUDIES ON INFLAMMATION

1961 • 1,539 citations

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

2001 • 1,517 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Focal Contacts as Mechanosensors

2001 • 1,390 citations

Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors

2000 • 1,372 citations

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

1999 • 1,372 citations

Integrins.

1991 • 1,369 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Focal adhesion kinase: the first ten years

2003 • 1,360 citations

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

1998 • 1,331 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

1999 • 1,291 citations

Angiopoietin-1 protects the adult vasculature against plasma leakage

2000 • 1,271 citations

Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis

2004 • 1,255 citations

Blood Vessel Formation: What Is Its Molecular Basis?

1996 • 1,242 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

Tensegrity I. Cell structure and hierarchical systems biology

2003 • 1,202 citations

Autophosphorylation of the Focal Adhesion Kinase, ppl25^FAK, Directs SH2-Dependent Binding of pp60^src

1994 • 1,168 citations

Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion

2000 • 1,167 citations

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

2001 • 1,144 citations

Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton

1993 • 1,124 citations

Endothelial cell–cell junctions: happy together

2004 • 1,123 citations

Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands

2000 • 1,118 citations

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

1998 • 1,077 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity

1989 • 1,032 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Vascular NAD(P)H oxidases: specific features, expression, and regulation

2003 • 1,029 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

Actin Binding Proteins: Regulation of Cytoskeletal Microfilaments

2003 • 1,022 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Filamins as integrators of cell mechanics and signalling

2001 • 987 citations

Caveolae: From Cell Biology to Animal Physiology

2002 • 977 citations

Filtration, Diffusion and Molecular Sieving Through Peripheral Capillary Membranes

1951 • 972 citations

Cytoskeletal regulation of pulmonary vascular permeability

2001 • 954 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

1998 • 923 citations

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

2000 • 913 citations

Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules.

1994 • 894 citations

VIP21/caveolin is a cholesterol-binding protein.

1995 • 892 citations

Molecular cloning of a potential proteinase activated receptor.

1994 • 887 citations

Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.

1998 • 887 citations

Protease-activated receptor 3 is a second thrombin receptor in humans

1997 • 878 citations

The relationship between force and focal complex development

2002 • 876 citations

The endothelial surface layer

2000 • 870 citations

Ion Channels and Their Functional Role in Vascular Endothelium

2001 • 850 citations

Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association

1998 • 849 citations

Adhesion-Dependent Cell Mechanosensitivity

2003 • 847 citations

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.

1994 • 844 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding

1995 • 816 citations

Endothelial Claudin

1999 • 802 citations

Oxidant stress and endothelial cell dysfunction

2001 • 802 citations

Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development

1999 • 795 citations

Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.

1991 • 795 citations

Control of cytoplasmic actin gel–sol transformation by gelsolin, a calcium-dependent regulatory protein

1979 • 782 citations

Src Tyrosine Kinases, Gα Subunits, and H-Ras Share a Common Membrane-anchored Scaffolding Protein, Caveolin

1996 • 770 citations

Microvascular Permeability

1999 • 769 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

Endothelial cell diversity revealed by global expression profiling

2003 • 763 citations

Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals

1995 • 760 citations

Regulated internalization of caveolae.

1994 • 760 citations

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

1990 • 753 citations

Electric Cell–Substrate Impedance Sensing (ECIS) as a Noninvasive Means to Monitor the Kinetics of Cell Spreading to Artificial Surfaces

2000 • 743 citations

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

1996 • 739 citations

Manner of Interaction of Heterogeneous Claudin Species within and between Tight Junction Strands

1999 • 724 citations

Beyond the gap: functions of unpaired connexon channels

2003 • 721 citations

A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth

1998 • 720 citations

Local Actin Polymerization and Dynamin Recruitment in SV40-Induced Internalization of Caveolae

2002 • 715 citations

Endocytosis Via Caveolae

2002 • 708 citations

flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors

1993 • 707 citations

Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits

2002 • 695 citations

Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells

1998 • 695 citations

Dynamin and Its Role in Membrane Fission

2000 • 689 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

Variants of the cell recognition site of fibronectin that retain attachment-promoting activity.

1984 • 685 citations

Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix

2002 • 676 citations

Ena/VASP Proteins: Regulators of the Actin Cytoskeleton and Cell Migration

2003 • 670 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

Dynamin Undergoes a GTP-Dependent Conformational Change Causing Vesiculation

1998 • 665 citations

Vascular endothelial–cadherin is an important determinant of microvascular integrityinvivo

1999 • 659 citations

AN ELECTRON MICROSCOPE STUDY OF THE MITOCHONDRIAL STRUCTURE

1953 • 658 citations

Dynamin at the Neck of Caveolae Mediates Their Budding to Form Transport Vesicles by GTP-driven Fission from the Plasma Membrane of Endothelium

1998 • 657 citations

Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin.

1995 • 651 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

A novel endothelial-specific membrane protein is a marker of cell-cell contacts.

1992 • 637 citations

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

2002 • 633 citations

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion

2003 • 631 citations

Transcytosis: Crossing Cellular Barriers

2003 • 629 citations

Occludin as a possible determinant of tight junction permeability in endothelial cells

1997 • 626 citations

Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase

2005 • 612 citations

Mechanical Signaling and the Cellular Response to Extracellular Matrix in Angiogenesis and Cardiovascular Physiology

2002 • 612 citations

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

1988 • 610 citations

Mice lacking vimentin develop and reproduce without an obvious phenotype

1994 • 603 citations

Identification of Distinct Luminal Domains for Macromolecules, Erythrocytes, and Leukocytes Within Mammalian Capillaries

1996 • 598 citations

Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor-2

1999 • 597 citations

De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin.

1995 • 597 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Steps toward mapping the human vasculature by phage display

2002 • 591 citations

Regulation of E-cadherin/Catenin Association by Tyrosine Phosphorylation

1999 • 589 citations

Paxillin: Adapting to Change

2004 • 582 citations

Distribution, properties, and functional characteristics of three classes of histamine receptor.

1990 • 579 citations

Multiple Functions of Caveolin-1

2002 • 579 citations

The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan

2003 • 578 citations

How the protease thrombin talks to cells

1999 • 574 citations

Heparan Sulfate Proteoglycan Is a Mechanosensor on Endothelial Cells

2003 • 572 citations

Oxidative Stress-Induced Actin Reorganization Mediated by the p38 Mitogen-Activated Protein Kinase/Heat Shock Protein 27 Pathway in Vascular Endothelial Cells

1997 • 569 citations

Biochemical signals and biological responses elicited by the focal adhesion kinase

2001 • 568 citations

Extracellular matrix and integrin signalling: the shape of things to come

1999 • 567 citations

Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4−/− mice

2001 • 567 citations

The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy.

1993 • 567 citations

P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases

2000 • 563 citations

Mechanotransduction and flow across the endothelial glycocalyx

2003 • 561 citations

The plasma membrane

1983 • 561 citations

In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation

2000 • 558 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

1997 • 549 citations

Oligomeric structure of caveolin: implications for caveolae membrane organization.

1995 • 547 citations

Vascular Endothelial Growth Factor: Molecular and Biological Aspects

1999 • 542 citations

Snares and munc18 in synaptic vesicle fusion

2002 • 537 citations

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

2001 • 530 citations

Phosphoinositide kinases

1996 • 529 citations

Role of Integrins in Endothelial Mechanosensing of Shear Stress

2002 • 526 citations

Small GTP-Binding Proteins

1992 • 526 citations

High Bronchoalveolar Levels of Tumor Necrosis Factor and Its Inhibitors, Interleukin-1, Interferon, and Elastase, in Patients with Adult Respiratory Distress Syndrome after Trauma, Shock, or Sepsis

1992 • 522 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

Human junction adhesion molecule regulates tight junction resealing in epithelia

2000 • 521 citations

Regulation of Gap Junctions by Phosphorylation of Connexins

2000 • 521 citations

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.

1992 • 519 citations

Endothelial progenitor cells for postnatal vasculogenesis

2004 • 518 citations

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex.

1993 • 510 citations

Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop

2000 • 507 citations

STUDIES ON BLOOD CAPILLARIES

1968 • 506 citations

Fine structures of capillary and endocapillary layer as revealed by ruthenium red.

1966 • 506 citations

Role of IQGAP1, a Target of the Small GTPases Cdc42 and Rac1, in Regulation of E-Cadherin- Mediated Cell-Cell Adhesion

1998 • 505 citations

Integrin signaling to the actin cytoskeleton

2003 • 497 citations

Angiopoietin-1 Is an Antipermeability and Anti-Inflammatory Agent In Vitro and Targets Cell Junctions

2000 • 496 citations

Endothelial signaling during development

2003 • 495 citations

Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity.

1994 • 493 citations

Direct Association of the Gap Junction Protein Connexin-43 with ZO-1 in Cardiac Myocytes

1998 • 492 citations

Protective Effects of Sphingosine 1-Phosphate in Murine Endotoxin-induced Inflammatory Lung Injury

2004 • 491 citations

Rho Guanine Dissociation Inhibitors

1999 • 487 citations

Regulation of vascular endothelial barrier function

1994 • 481 citations

The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.

1995 • 479 citations

Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells

1997 • 477 citations

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

1998 • 473 citations

Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor

1992 • 472 citations

Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling

1999 • 466 citations

VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro.

1995 • 465 citations

cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca²⁺ mobilization

1991 • 464 citations

Cortical Actin Organization: Lessons from ERM (Ezrin/Radixin/Moesin) Proteins

1999 • 464 citations

Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis

2004 • 462 citations

International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

2002 • 462 citations

Rho and Rac but not Cdc42 regulate endothelial cell permeability

2001 • 462 citations

Caveolae and sorting in the trans-Golgi network of epithelial cells.

1993 • 461 citations

Inhibition of RhoA by p120 catenin

2000 • 459 citations

Rho GTPases and the regulation of endothelial permeability

2002 • 457 citations

Vesicle tethering complexes in membrane traffic

2002 • 456 citations

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

1999 • 456 citations

Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study

1992 • 456 citations

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation.

1995 • 451 citations

The small GTPase RalA targets filamin to induce filopodia

1999 • 449 citations

MAGUK proteins: structure and role in the tight junction

2000 • 448 citations

The interplay between Src family kinases and receptor tyrosine kinases

2004 • 446 citations

A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein.

1991 • 445 citations

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

1994 • 441 citations

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

1995 • 437 citations

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

1991 • 435 citations

Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice

2002 • 434 citations

Segmental differentiations of cell junctions in the vascular endothelium. The microvasculature.

1975 • 430 citations

Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions

1999 • 430 citations

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

2000 • 429 citations

The p120 catenin family: Complex roles in adhesion, signaling and cancer

2000 • 427 citations

Junctional Adhesion Molecule Interacts with the PDZ Domain-containing Proteins AF-6 and ZO-1

2000 • 426 citations

Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function.

1992 • 424 citations

Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein

1997 • 424 citations

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.

1995 • 423 citations

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site.

1995 • 422 citations

Cadherin Engagement Regulates Rho family GTPases

2001 • 421 citations

Calcium pump of the plasma membrane is localized in caveolae.

1993 • 419 citations

Monocytes coexpress endothelial and macrophagocytic lineage markers and form cord-like structures in Matrigel® under angiogenic conditions

2001 • 418 citations

Cortactin: coupling membrane dynamics to cortical actin assembly

2001 • 413 citations

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.

1993 • 408 citations

Regulation of vascular permeability by vascular endothelial growth factors

2002 • 404 citations

Assembly of Trp1 in a Signaling Complex Associated with Caveolin-Scaffolding Lipid Raft Domains

2000 • 403 citations

Dynamin and its partners: a progress report

1998 • 403 citations

A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling

1999 • 402 citations

Multiple connections link FAK to cell motility and invasion

2003 • 402 citations

Recruitment of the Arp2/3 complex to vinculin

2002 • 401 citations

Protein kinase C, calcium and phospholipid degradation

1992 • 400 citations

Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo

2001 • 400 citations

Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands

2001 • 398 citations

Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit

1993 • 395 citations

Interaction of Focal Adhesion Kinase with Cytoskeletal Protein Talin

1995 • 393 citations

A fiber matrix model of capillary permeability

1980 • 392 citations

Protein phosphatases: recent progress.

1991 • 391 citations

Regulation of TNF-α-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells

1998 • 390 citations

NADPH oxidases: not just for leukocytes anymore!

2003 • 387 citations

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 • 385 citations

CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion.

1992 • 383 citations

CD34 ⁺ and Endothelial Progenitor Cells in Patients With Various Degrees of Congestive Heart Failure

2004 • 383 citations

Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables

2003 • 380 citations

Actin-binding proteins

2005 • 376 citations

Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: receptor-mediated transcytosis.

1986 • 375 citations

Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability

2003 • 375 citations

Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility

1995 • 374 citations

How does calcium trigger neurotransmitter release?

2001 • 371 citations

Gp60 Activation Mediates Albumin Transcytosis in Endothelial Cells by Tyrosine Kinase-dependent Pathway

1997 • 371 citations

Endothelial Caveolae Have the Molecular Transport Machinery for Vesicle Budding, Docking, and Fusion Including VAMP, NSF, SNAP, Annexins, and GTPases

1995 • 370 citations

Segregation of Heterotrimeric G Proteins in Cell Surface Microdomains

2001 • 370 citations

Inflammation- and ischemia-induced shedding of venular glycocalyx

2004 • 369 citations

Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues

1993 • 369 citations

Immunoelectron microscopic studies of the sites of cell-substratum and cell-cell contacts in cultured fibroblasts.

1982 • 369 citations

CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium.

1995 • 367 citations

INTESTINAL CAPILLARIES

1969 • 366 citations

Regulation of cortical structure by the ezrin-radixin-moesin protein family

1999 • 365 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

Endothelial cells use alpha 2 beta 1 integrin as a laminin receptor.

1989 • 363 citations

Impairment of Store-Operated Ca ²⁺ Entry in TRPC4 ^−/− Mice Interferes With Increase in Lung Microvascular Permeability

2002 • 363 citations

Caveolin, Caveolae, and Endothelial Cell Function

2003 • 363 citations

Tyrosine Phosphorylation of a 22-kDa Protein Is Correlated with Transformation by Rous Sarcoma Virus

1989 • 363 citations

GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila

2003 • 360 citations

Involvement of microtubules in the control of adhesion-dependent signal transduction

1996 • 358 citations

Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP

2001 • 357 citations

Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase

2004 • 356 citations

Caveolin Is Palmitoylated on Multiple Cysteine Residues

1995 • 356 citations

Passage of dextran molecules across the blood-lymph barrier.

1956 • 354 citations

Angiopoietin-1 Reduces VEGF-Stimulated Leukocyte Adhesion to Endothelial Cells by Reducing ICAM-1, VCAM-1, and E-Selectin Expression

2001 • 354 citations

Caldesmon, a novel regulatory protein in smooth muscle and nonmuscle actomyosin systems

1991 • 353 citations

Coupling of PAK-Interacting Exchange Factor PIX to GIT1 Promotes Focal Complex Disassembly

2000 • 353 citations

Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae

2005 • 349 citations

Thrombin Inactivates Myosin Light Chain Phosphatase via Rho and Its Target Rho Kinase in Human Endothelial Cells

1998 • 348 citations

Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members.

1994 • 347 citations

Phosphorylation of Caveolin by Src Tyrosine Kinases

1996 • 347 citations

The dynamin family of mechanoenzymes: pinching in new places

2000 • 345 citations

Localization of inositol 1,4,5-trisphosphate receptor-like protein in plasmalemmal caveolae.

1992 • 345 citations

Paxillin interactions

2000 • 342 citations

Cellular consequences of thrombin-receptor activation

1996 • 341 citations

Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex.

1995 • 341 citations

Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.

1995 • 341 citations

Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression

2002 • 340 citations

Integrin-mediated Cell Adhesion Promotes Tyrosine Phosphorylation of p130Cas, a Src Homology 3-containing Molecule Having Multiple Src Homology 2-binding Motifs

1995 • 340 citations

α-Catenin-Vinculin Interaction Functions to Organize the Apical Junctional Complex in Epithelial Cells

1998 • 338 citations

Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.

1995 • 337 citations

An SH3 Domain-Containing GTPase-Activating Protein for Rho and Cdc42 Associates with Focal Adhesion Kinase

1996 • 337 citations

A gene family consisting of ezrin, radixin and moesin Its specific localization at actin filament/plasma membrane association sites

1992 • 334 citations

Defects in Cell Adhesion and the Visceral Endoderm following Ablation of Nonmuscle Myosin Heavy Chain II-A in Mice

2004 • 333 citations

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.

1994 • 331 citations

p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction

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Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues.

1996 • 329 citations

Control of actin assembly and disassembly at filament ends

2000 • 329 citations

Reversible and Covalent Binding of Drugs to Human Serum Albumin: Methodological Approaches and Physiological Relevance

2002 • 328 citations

Spectrin tethers and mesh in the biosynthetic pathway

2000 • 326 citations

Caveolae-deficient Endothelial Cells Show Defects in the Uptake and Transport of Albumin in Vivo

2001 • 325 citations

Endothelial cell heterogeneity

2003 • 323 citations

The Hemostatic System as a Regulator of Angiogenesis

2000 • 322 citations

Role of glycocalyx in leukocyte-endothelial cell adhesion

2002 • 321 citations

Capillary endothelial surface layer selectively reduces plasma solute distribution volume

2000 • 320 citations

Constitutive and Growth Factor-Regulated Phosphorylation of Caveolin-1 Occurs at the Same Site (Tyr-14) in Vivo: Identification of a c-Src/Cav-1/Grb7 Signaling Cassette

2000 • 320 citations

The Thyroxine-Binding Proteins

2000 • 318 citations

Caveolin-2-Deficient Mice Show Evidence of Severe Pulmonary Dysfunction without Disruption of Caveolae

2002 • 318 citations

The Role of the Microtubules in Tumor Necrosis Factor-α–Induced Endothelial Cell Permeability

2003 • 316 citations

Identification of IQGAP as a Putative Target for the Small GTPases, Cdc42 and Rac1

1996 • 315 citations

Role of hyaluronic acid glycosaminoglycans in shear-induced endothelium-derived nitric oxide release

2003 • 315 citations

VE-cadherin antibody accelerates neutrophil recruitment in vivo

1997 • 314 citations

Oncotic pressures opposing filtration across non‐fenestrated rat microvessels

2004 • 314 citations

Albondin-mediated capillary permeability to albumin. Differential role of receptors in endothelial transcytosis and endocytosis of native and modified albumins.

1994 • 314 citations

Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.

1995 • 313 citations

The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.

1992 • 312 citations

TNF-α increases entry of macromolecules into luminal endothelial cell glycocalyx

2000 • 311 citations

The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin

2001 • 311 citations

Microvascular Hyperpermeability in Caveolin-1 (−/−) Knock-out Mice

2002 • 311 citations

IQGAP proteins are integral components of cytoskeletal regulation

2003 • 311 citations

Segmental differentiations of cell junctions in the vascular endothelium. Arteries and veins.

1976 • 311 citations

Thrombin-Induced Increase in Endothelial Permeability Is Associated With Changes in Cell-to-Cell Junction Organization

1996 • 309 citations

The conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility

2003 • 308 citations

Regulation of caveolin and caveolae by cholesterol in MDCK cells

1998 • 307 citations

Thrombin‐induced increase in albumin permeability across the endothelium

1986 • 307 citations

Serine Phosphorylation Negatively Regulates RhoA in Vivo

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Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.

1995 • 304 citations

VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts

2002 • 303 citations

Caveolin-1 and -2 in the Exocytic Pathway of MDCK Cells

1998 • 303 citations

Identification of Filamin as a Novel Ligand for Caveolin-1: Evidence for the Organization of Caveolin-1–associated Membrane Domains by the Actin Cytoskeleton

2000 • 303 citations

Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis

2003 • 302 citations

COOH Terminus of Occludin Is Required for Tight Junction Barrier Function in Early Xenopus Embryos

1997 • 301 citations

Cadherin-Directed Actin Assembly

2002 • 301 citations

Regulation of Tight Junction Permeability and Occludin Phosphorylation by RhoA-p160ROCK-dependent and -independent Mechanisms

2001 • 300 citations

Hypoxia-Induced Hyperpermeability in Brain Microvessel Endothelial Cells Involves VEGF-Mediated Changes in the Expression of Zonula Occludens-1

2002 • 299 citations

Caveolin regulation of endothelial function

2003 • 297 citations

Cloning and Characterization of GEF-H1, a Microtubule-associated Guanine Nucleotide Exchange Factor for Rac and Rho GTPases

1998 • 296 citations

Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton

2002 • 296 citations

Pulmonary Endothelial Cell Barrier Enhancement by Sphingosine 1-Phosphate

2004 • 295 citations

A Mathematical Model

1987 • 295 citations

THE FINE STRUCTURE OF THE RENAL GLOMERULUS OF THE MOUSE

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Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability

2001 • 293 citations

Role of Ca2+ signaling in the regulation of endothelial permeability

2002 • 292 citations

Actin Depolymerization Disrupts Tight Junctions via Caveolae-mediated Endocytosis

2005 • 292 citations

MORPHOMETRIC DATA ON THE ENDOTHELIUM OF BLOOD CAPILLARIES

1974 • 291 citations

Intersectin, a Novel Adaptor Protein with Two Eps15 Homology and Five Src Homology 3 Domains

1998 • 291 citations

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1–deficient mice

2002 • 290 citations

The role of integrins in the maintenance of endothelial monolayer integrity.

1991 • 290 citations

Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers.

1986 • 289 citations

Endothelial Cell-Surface Gp60 Activates Vesicle Formation and Trafficking via Gi-Coupled Src Kinase Signaling Pathway

2000 • 289 citations

Actin dynamics and cell–cell adhesion in epithelia

2001 • 288 citations

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

2005 • 288 citations

Vascular Endothelial Growth Factor Increases Release of Gelatinase A and Decreases Release of Tissue Inhibitor of Metalloproteinases by Microvascular Endothelial Cellsin Vitro

1998 • 287 citations

Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes

2004 • 286 citations

Phosphorylation and Free Pool of β-Catenin Are Regulated by Tyrosine Kinases and Tyrosine Phosphatases during Epithelial Cell Migration

1999 • 286 citations

Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells

1997 • 285 citations

Direct cadherin-activated cell signaling

2002 • 285 citations

Connexin 43 and connexin 40 gap junctional proteins are present in arteriolar smooth muscle and endothelium in vivo

1995 • 285 citations

Multiple Developmental Roles of VEGF Suggested by a LacZ-Tagged Allele

1999 • 284 citations

Akt-Mediated Phosphorylation of the G Protein-Coupled Receptor EDG-1 Is Required for Endothelial Cell Chemotaxis

2001 • 284 citations

Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth

1999 • 281 citations

Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis

2000 • 281 citations

Coupling actin dynamics and membrane dynamics during endocytosis

2002 • 280 citations

Emerging roles for p120-catenin in cell adhesion and cancer

2004 • 280 citations

Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin.

1996 • 280 citations

Neutrophil transendothelial migration is independent of tight junctions and occurs preferentially at tricellular corners.

1997 • 280 citations

Albumin-Deficient Rat Mutant

1979 • 277 citations

Endothelial cell proliferation during angiogenesis. In vitro modulation by basement membrane components.

1986 • 277 citations

Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis

2000 • 276 citations

Host nutritional selenium status as a driving force for influenza virus mutations

2001 • 275 citations

Vascular endothelial groth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: Conversion of prothrombin to thrombin results in progelatininase a activation and cell proliferation

1998 • 274 citations

Quasi-Periodic Substructure in the Microvessel Endothelial Glycocalyx: A Possible Explanation for Molecular Filtering?

2001 • 274 citations

Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins).

1996 • 274 citations

Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex

2004 • 274 citations

Occludin confers adhesiveness when expressed in fibroblasts

1997 • 272 citations

PERMEABILITY OF INTESTINAL CAPILLARIES

1972 • 272 citations

p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion

2001 • 272 citations

Signaling and biological actions of sphingosine 1-phosphate

2003 • 272 citations

The Vesiculo–Vacuolar Organelle (VVO): A New Endothelial Cell Permeability Organelle

2001 • 271 citations

Internalization and recycling of activated thrombin receptors

1993 • 271 citations

Transcytosis of albumin in capillary endothelium.

1987 • 269 citations

Blood-brain barrier carrier-mediated transport and brain metabolism of amino acids.

1998 • 268 citations

Differentiated microdomains on the luminal surface of the capillary endothelium. I. Preferential distribution of anionic sites.

1981 • 267 citations

Transient and Prolonged Increase in Endothelial Permeability Induced by Histamine and Thrombin

1998 • 266 citations

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

2003 • 266 citations

Regulation of Rho GTPases by p120-catenin

2001 • 265 citations

Selective Stimulation of Caveolar Endocytosis by Glycosphingolipids and Cholesterol

2004 • 265 citations

Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch

2003 • 263 citations

Quantitative analysis of albumin uptake and transport in the rat microvessel endothelial monolayer

2003 • 262 citations

Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical.

1985 • 262 citations

Dynamin Self-assembly Stimulates Its GTPase Activity

1996 • 262 citations

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1–deficient mice

2002 • 261 citations

Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members

2001 • 261 citations

Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay

2004 • 260 citations

Vinculin Is Part of the Cadherin–Catenin Junctional Complex: Complex Formation between α-Catenin and Vinculin

1998 • 260 citations

TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase

2003 • 259 citations

Regulation of Cadherin Function by Rho and Rac: Modulation by Junction Maturation and Cellular Context

1999 • 257 citations

Functional Domains of α-Catenin Required for the Strong State of Cadherin-based Cell Adhesion

1999 • 257 citations

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

1993 • 257 citations

Bradykinin Sequesters B2 Bradykinin Receptors and the Receptor-coupled Gα Subunits Gαq and Gαiin Caveolae in DDT1 MF-2 Smooth Muscle Cells

1997 • 256 citations

Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cells.

1988 • 256 citations

Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol

1997 • 256 citations

Activation of a Novel Calcium-dependent Protein-tyrosine Kinase

1996 • 256 citations

Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

1995 • 255 citations

Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

1999 • 255 citations

Molecular sieving characteristics of the cultured endothelial monolayer

1987 • 254 citations

Molecular architecture of intermediate filaments

2003 • 254 citations

Protein Kinase C-α Signals Rho-Guanine Nucleotide Dissociation Inhibitor Phosphorylation and Rho Activation and Regulates the Endothelial Cell Barrier Function

2001 • 253 citations

Direct interaction of filamin (ABP-280) with the beta 2-integrin subunit CD18.

1995 • 252 citations

p120 catenin associates with kinesin and facilitates the transport of cadherin–catenin complexes to intercellular junctions

2003 • 251 citations

Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties

1989 • 251 citations

An interaction between zyxin and alpha-actinin.

1992 • 251 citations

Involvement of myosin light-chain kinase in endothelial cell retraction.

1990 • 249 citations

Preservation of Vascular Integrity in Organs perfused in vitro with a Platelet-rich Medium

1969 • 249 citations

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.

1992 • 248 citations

Fusion of Cells by Flipped SNAREs

2003 • 248 citations

PV-1 is a component of the fenestral and stomatal diaphragms in fenestrated endothelia

1999 • 248 citations

VEGF induces NO-dependent hyperpermeability in coronary venules

1996 • 247 citations

Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells

1993 • 246 citations

Identification of gelsolin, a Ca2+-dependent regulatory protein of actin gel-sol transformation, and its intracellular distribution in a variety of cells and tissues.

1981 • 246 citations

Isoforms of caveolin-1 and caveolar structure

2000 • 244 citations

JAM-2, a Novel Immunoglobulin Superfamily Molecule, Expressed by Endothelial and Lymphatic Cells

2001 • 242 citations

Molecular and cellular permeability control at the blood–brain barrier

2001 • 242 citations

Dynamin at the actin–membrane interface

2003 • 241 citations

VE-Cadherin Regulates Endothelial Actin Activating Rac and Increasing Membrane Association of Tiam

2002 • 241 citations

Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers

1997 • 241 citations

The role of FGF and VEGF in angioblast induction and migration during vascular development

2001 • 240 citations

Inhibition of angiogenesis through modulation of collagen metabolism.

1988 • 240 citations

Domain structure and intramolecular regulation of dynamin GTPase

1997 • 239 citations

PECAM-1: old friend, new partners

2003 • 239 citations

Vascular Endothelial Junction-associated Molecule, a Novel Member of the Immunoglobulin Superfamily, Is Localized to Intercellular Boundaries of Endothelial Cells

2000 • 239 citations

Blockade of Inflammation and Airway Hyperresponsiveness in Immune-sensitized Mice by Dominant-Negative Phosphoinositide 3-Kinase–TAT

2003 • 238 citations

Regulation of the Actin Cytoskeleton by Thrombin in Human Endothelial Cells: Role of Rho Proteins in Endothelial Barrier Function

1998 • 238 citations

The Structure and Function of Claudins, Cell Adhesion Molecules at Tight Junctions

2000 • 237 citations

Protease-activated Receptors 1 and 4 Are Shut Off with Distinct Kinetics after Activation by Thrombin

2000 • 236 citations

A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites.

1991 • 234 citations

Protein kinase signaling in the modulation of microvascular permeability

2002 • 234 citations

The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments.

1991 • 233 citations

The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin

2000 • 232 citations

Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice

2001 • 232 citations

Roles played by a subset of integrin signaling molecules in cadherin-based cell–cell adhesion

2004 • 230 citations

Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.

1994 • 230 citations

Histamine Induces Tyrosine Phosphorylation of Endothelial Cell-to-Cell Adherens Junctions

1999 • 229 citations

Heparinase treatment suggests a role for the endothelial cell glycocalyx in regulation of capillary hematocrit

1990 • 226 citations

Lysophospholipid receptor nomenclature

2002 • 225 citations

Changes in membrane-microfilament interaction in intercellular adherens junctions upon removal of extracellular Ca2+ ions.

1986 • 225 citations

The large GTPase dynamin regulates actin comet formation and movement in living cells

2002 • 224 citations

Cdc42 and Rac1 Regulate the Interaction of IQGAP1 with β-Catenin

1999 • 223 citations

Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells

1993 • 222 citations

Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice

1999 • 221 citations

A Tyrosine-phosphorylated Protein That Binds to an Important Regulatory Region on the Cool Family of p21-activated Kinase-binding Proteins

1999 • 221 citations

Targeted null-mutation in the vascular endothelial–cadherin gene impairs the organization of vascular-like structures in embryoid bodies

1997 • 221 citations

Myosin‐V, a Versatile Motor for Short‐Range Vesicle Transport

2002 • 220 citations

Catenin-dependent and -independent Functions of Vascular Endothelial Cadherin

1995 • 220 citations

Mechanisms of increased endothelial permeability

1996 • 218 citations

RhoA Interaction with Inositol 1,4,5-Trisphosphate Receptor and Transient Receptor Potential Channel-1 Regulates Ca2+ Entry

2003 • 218 citations

Sphingosine 1-Phosphate Reduces Vascular Leak in Murine and Canine Models of Acute Lung Injury

2004 • 217 citations

Ca²⁺ signalling and PKCα activate increased endothelial permeability by disassembly of VE—cadherin junctions

2001 • 216 citations

Interleukin-6 Causes Endothelial Barrier Dysfunction via the Protein Kinase C Pathway

2002 • 216 citations

Shear stress increases inositol trisphosphate levels in human endothelial cells

1990 • 215 citations

Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.

1994 • 214 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton.

1996 • 212 citations

SHP2 Association with VE-Cadherin Complexes in Human Endothelial Cells Is Regulated by Thrombin

2000 • 212 citations

Shear Stress-Mediated Cytoskeletal Remodeling and Cortactin Translocation in Pulmonary Endothelial Cells

2002 • 212 citations

Role of Src-induced Dynamin-2 Phosphorylation in Caveolae-mediated Endocytosis in Endothelial Cells

2004 • 211 citations

Caveolin-1 Contributes to Assembly of Store-operated Ca2+ Influx Channels by Regulating Plasma Membrane Localization of TRPC1

2003 • 211 citations

A Dynamin–Cortactin–Arp2/3 Complex Mediates Actin Reorganization in Growth Factor-stimulated Cells

2003 • 211 citations

Cellular functions of the Rap1 GTP-binding protein: a pattern emerges

2002 • 211 citations

gp60 is an albumin-binding glycoprotein expressed by continuous endothelium involved in albumin transcytosis

1992 • 210 citations

Reversible oxidant-induced increases in albumin transfer across cultured endothelium: alterations in cell shape and calcium homeostasis

1985 • 210 citations

Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells

2000 • 210 citations

Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface

1994 • 210 citations

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

2002 • 209 citations

Hyperoxic injury decreases alveolar epithelial cell expression of vascular endothelial growth factor (VEGF) in neonatal rabbit lung.

1997 • 209 citations

Vascular-endothelial-cadherin modulates endothelial monolayer permeability

1999 • 209 citations

The Biology of Caveolae: Lessons from Caveolin Knockout Mice and Implications for Human Disease

2003 • 208 citations

Endostatin associates with integrin alpha5beta1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells.

2002 • 208 citations

Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces.

1996 • 206 citations

Expression of Caveolin-1 Is Required for the Transport of Caveolin-2 to the Plasma Membrane

1999 • 205 citations

Oligomerization of VIP21‐caveolin in vitro is stabilized by long chain fatty acylation or cholesterol

1996 • 205 citations

Dap160, a Neural-specific Eps15 Homology and Multiple SH3 Domain-containing Protein That Interacts with DrosophilaDynamin

1998 • 205 citations

Regulation of cadherin-mediated cell–cell adhesion by the Rho family GTPases

1999 • 204 citations

TUMOUR NECROSIS FACTOR IN BRONCHOPULMONARY SECRETIONS OF PATIENTS WITH ADULT RESPIRATORY DISTRESS SYNDROME

1989 • 202 citations

Myosin light chain kinase in endothelium: molecular cloning and regulation.

1997 • 200 citations

FUNCTIONAL SIGNIFICANCE OF VENOUS BLOOD PRESSURE

1950 • 199 citations

Vesicle formation and trafficking in endothelial cells and regulation of endothelial barrier function

2002 • 198 citations

RAC1 Regulates Adherens Junctions through Endocytosis of E-Cadherin

2001 • 198 citations

Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration.

2001 • 198 citations

Caveolin forms a hetero-oligomeric protein complex that interacts with an apical GPI-linked protein: implications for the biogenesis of caveolae.

1993 • 197 citations

Motor–cargo interactions: the key to transport specificity

2002 • 197 citations

Microtubule Depolymerization Induces Stress Fibers, Focal Adhesions, and DNA Synthesis via the GTP-Binding Protein Rho

1998 • 197 citations

VAMP2-Dependent Exocytosis Regulates Plasma Membrane Insertion of TRPC3 Channels and Contributes to Agonist-Stimulated Ca2+ Influx

2004 • 197 citations

Identification of αvβ3 as a heterotypic ligand for CD31/PECAM-1

1996 • 197 citations

Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells.

1994 • 196 citations

Integration of signals to the Arp2/3 complex

2003 • 196 citations

VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo

1998 • 195 citations

Tumor Necrosis Factor Levels in Serum and Bronchoalveolar Lavage Fluid of Patients with the Adult Respiratory Distress Syndrome

1991 • 193 citations

Filamin Binds to the Cytoplasmic Domain of the β1-Integrin

1998 • 193 citations

Binding of human thrombin to cultured human endothelial cells.

1979 • 193 citations

Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor.

1990 • 193 citations

A Molecular Dissection of Caveolin-1 Membrane Attachment and Oligomerization

2000 • 192 citations

Novel role of microtubules in thrombin‐induced endothelial barrier dysfunction

2004 • 192 citations

Casein Kinase 1 Regulates Connexin-43 Gap Junction Assembly

2002 • 192 citations

Vascular Abnormalities in Mice Lacking the Endothelial Gap Junction Proteins connexin37 and connexin40

2002 • 191 citations

Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels.

1992 • 191 citations

Cytoskeletal and morphologic impact of cellular oxidant injury.

1986 • 190 citations

Endothelial cell barrier regulation by sphingosine 1‐phosphate

2004 • 189 citations

IQGAP1 Integrates Ca2+/Calmodulin and B-Raf Signaling

2008 • 189 citations

IQGAP1 Integrates Ca2+/Calmodulin and Cdc42 Signaling

1999 • 189 citations

PKA inhibits RhoA activation: a protection mechanism against endothelial barrier dysfunction

2003 • 189 citations

Identification and characterization of cell-substratum adhesion receptors on cultured human endothelial cells.

1989 • 186 citations

alpha-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase.

1994 • 186 citations

Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein).

1995 • 185 citations

Direct Interaction of Focal Adhesion Kinase with p190RhoGEF

2003 • 184 citations

Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: Role of Rho‐dependent mechanisms

2004 • 183 citations

The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells.

1996 • 183 citations

Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells

2001 • 183 citations

Increased Vascular Endothelial Growth Factor Production in the Lungs of Rats with Hypoxia-induced Pulmonary Hypertension

1998 • 183 citations

Cachetin/TNF-α in Septic Shock and Septic Adult Respiratory Distress Syndrome

1988 • 183 citations

Interactions between the innate immune and blood coagulation systems

2004 • 180 citations

Regulation of Actin Dynamics by WASP Family Proteins

2003 • 180 citations

Splice Variants of Intersectin Are Components of the Endocytic Machinery in Neurons and Nonneuronal Cells

1999 • 180 citations

Role of reactive oxygen species in reperfusion injury of the rabbit lung.

1989 • 180 citations

VE-cadherin: adhesion at arm's length

2004 • 180 citations

Specific Phospholipid Oxidation Products Inhibit Ligand Activation of Toll-Like Receptors 4 and 2

2003 • 180 citations

Mechanotransduction in Endothelial Cells: Temporal Signaling Events in Response to Shear Stress

1997 • 179 citations

Focal Adhesion Kinase Regulation of N-WASP Subcellular Localization and Function

2004 • 179 citations

VEGF induces hyperpermeability by a direct action on endothelial cells

1998 • 178 citations

Role of vasodilator‐stimulated phosphoprotein in protein kinase A‐induced changes in endothelial junctional permeability

2002 • 177 citations

Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells

2003 • 177 citations

Palmitoylation of Caveolin-1 Is Required for Cholesterol Binding, Chaperone Complex Formation, and Rapid Transport of Cholesterol to Caveolae

2000 • 176 citations

Open junctions in the endothelium of the postcapillary venules of the diaphragm.

1978 • 176 citations

Coupling membrane protrusion and cell adhesion

2003 • 176 citations

Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP

2001 • 175 citations

Mobilized Endothelial Progenitor Cells by Granulocyte-Macrophage Colony-Stimulating Factor Accelerate Reendothelialization and Reduce Vascular Inflammation After Intravascular Radiation

2003 • 175 citations

Identification of Caveolin and Caveolin-Related Proteins in the Brain

1997 • 175 citations

Structural basis of permeability in sequential segments of the microvasculature of the diaphragm

1978 • 175 citations

Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivo

2001 • 175 citations

Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells.

1991 • 174 citations

Protein Kinase Cα Phosphorylates the TRPC1 Channel and Regulates Store-operated Ca2+ Entry in Endothelial Cells

2004 • 174 citations

Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines

1997 • 174 citations

Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products

2003 • 173 citations

Inhibition of p38 MAPK Activation via Induction of MKP-1

2002 • 172 citations

Role of RhoA and Rho Kinase in Lysophosphatidic Acid–Induced Endothelial Barrier Dysfunction

2000 • 172 citations

Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

1997 • 172 citations

Characterization of p190RhoGEF, A RhoA-specific Guanine Nucleotide Exchange Factor That Interacts with Microtubules

2001 • 172 citations

Tensin

2003 • 171 citations

E-selectin expression in human endothelial cells by TNF-α-induced oxidant generation and NF-κB activation

1998 • 171 citations

Evidence for a pulmonary B3 bradykinin receptor.

1989 • 171 citations

Albumin uptake and transcytosis in endothelial cells in vivo induced by albumin-binding protein

2001 • 171 citations

Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and CD18-dependent mechanisms.

1992 • 170 citations

Hormonal regulation of caveolae internalization.

1995 • 170 citations

Morphology Favors an Endothelial Cell Pathway for Longitudinal Conduction within Arterioles

1997 • 169 citations

Functional Co-localization of Transfected Ca2+-stimulable Adenylyl Cyclases with Capacitative Ca2+ Entry Sites

1996 • 168 citations

Vascular endothelial growth factor increases hydraulic conductivity of isolated perfused microvessels

1996 • 167 citations

Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation

2001 • 167 citations

Reconstitution of Receptors and GTP-binding Regulatory Proteins (G Proteins) in Sf9 Cells

1997 • 166 citations

The N-termini of FAK and JAKs contain divergent band 4.1 domains

1999 • 166 citations

Role of the Sphingosine 1-Phosphate Receptor EDG-1 in Vascular Smooth Muscle Cell Proliferation and Migration

2001 • 166 citations

Signals from platelet/endothelial cell adhesion molecule enhance the adhesive activity of the very late antigen-4 integrin of human CD34+ hemopoietic progenitor cells.

1994 • 166 citations

Multiple roles for Cdc42 in cell regulation

2001 • 165 citations

Regulation of endothelial cell gap formation and paracellular permeability.

1995 • 165 citations

Distinct Actions and Cooperative Roles of ROCK and mDia in Rho Small G Protein-induced Reorganization of the Actin Cytoskeleton in Madin–Darby Canine Kidney Cells

1999 • 165 citations

The Association of ASAP1, an ADP Ribosylation Factor-GTPase Activating Protein, with Focal Adhesion Kinase Contributes to the Process of Focal Adhesion Assembly

2002 • 164 citations

Angiopoietin-1 Opposes VEGF-Induced Increase in Endothelial Permeability by Inhibiting TRPC1-Dependent Ca ² Influx

2005 • 164 citations

The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL)

2001 • 164 citations

Cadherin Engagement Inhibits RhoA via p190RhoGAP

2003 • 164 citations

Mutational Analysis of the Properties of Caveolin-1

1997 • 164 citations

Protein kinase C phosphorylates caldesmon₇₇ and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1992 • 163 citations

EHSH1/Intersectin, a Protein That Contains EH and SH3 Domains and Binds to Dynamin and SNAP-25

1999 • 163 citations

Interendothelial Junctions and their Role in the Control of Angiogenesis, Vascular Permeability and Leukocyte Transmigration

2001 • 163 citations

Serum albumin: recent progress in the understanding of its structure and biosynthesis.

1977 • 162 citations

Recombinant tumor necrosis factor increases pulmonary vascular permeability independent of neutrophils.

1988 • 161 citations

The Tight Junction Protein Occludin and the Adherens Junction Protein α-Catenin Share a Common Interaction Mechanism with ZO-1

2004 • 161 citations

Expression of caveolin-1 and polarized formation of invaginated caveolae in Caco-2 and MDCK II cells

1998 • 159 citations

Ypt/Rab GTPases: Regulators of Protein Trafficking

2001 • 158 citations

An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin [see comments]

1989 • 158 citations

Tumor necrosis factor-α-induced TRPC1 expression amplifies store-operated Ca²⁺influx and endothelial permeability

2004 • 158 citations

Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60^src

1999 • 157 citations

The Catalytic Activity of the Src Family Kinases Is Required to Disrupt Cadherin-dependent Cell–Cell Contacts

2000 • 156 citations

Pulmonary microvascular and macrovascular endothelial cells: differential regulation of Ca²⁺and permeability

1998 • 155 citations

Sphingosine 1-Phosphate-induced Mobilization of Intracellular Ca2+ Mediates Rac Activation and Adherens Junction Assembly in Endothelial Cells

2005 • 155 citations

Arg-Gly-Asp peptide increases endothelial hydraulic conductivity: comparison with thrombin response

1995 • 155 citations

Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways

2003 • 155 citations

Shear stress‐induced calcium transients in endothelial cells from human umbilical cord veins.

1992 • 154 citations

Emerging role of myeloperoxidase and oxidant stress markers in cardiovascular risk assessment

2003 • 154 citations

Src-mediated Tyrosine Phosphorylation of Caveolin-1 Induces Its Association with Membrane Type 1 Matrix Metalloproteinase

2004 • 154 citations

Angiopoietin‐1 inhibits endothelial permeability, neutrophil adherence and IL‐8 production

2003 • 154 citations

Albumin mediates the transcytosis of myeloperoxidase by means of caveolae in endothelial cells

2004 • 153 citations

Cellular carboxypeptidases

1998 • 153 citations

The Dbl-related Protein, Lfc, Localizes to Microtubules and Mediates the Activation of Rac Signaling Pathways in Cells

1999 • 153 citations

VASP interaction with vinculin: a recurring theme of interactions with proline‐rich motifs

1996 • 152 citations

A mechanism for heterogeneous endothelial responses to flow in vivo and in vitro

1995 • 152 citations

Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets

2000 • 152 citations

Transendothelial Transport: The Vesicle Controversy

2002 • 152 citations

Dynamin GTPase, a force‐generating molecular switch

1996 • 150 citations

Differential Regulation of Alternatively Spliced Endothelial Cell Myosin Light Chain Kinase Isoforms by p60Src

2001 • 150 citations

Hydrogen peroxide in expired breath condensate of patients with acute respiratory failure and with ARDS

1993 • 150 citations

Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway

1997 • 150 citations

Signal transduction and regulation of lung endothelial cell permeability. Interaction between calcium and cAMP

1998 • 150 citations

Regulation of permeabilized endothelial cell retraction by myosin phosphorylation

1991 • 149 citations

Direct effects of E coli endotoxin on structure and permeability of pulmonary endothelial monolayers and the endothelial layer of intimal explants.

1986 • 149 citations

Permeability of frog mesenteric capillaries after partial pronase digestion of the endothelial glycocalyx.

1990 • 149 citations

Extrinsic regulators of epithelial tumor progression: metalloproteinases

2000 • 149 citations

Targets for pharmacological intervention of endothelial hyperpermeability and barrier function

2002 • 149 citations

Localization of the permeability barrier to solutes in isolated arteries by confocal microscopy

2003 • 147 citations

C-Terminal Threonine Phosphorylation Activates ERM Proteins to Link the Cell's Cortical Lipid Bilayer to the Cytoskeleton

1998 • 147 citations

Preferential interaction of albumin-binding proteins, gp30 and gp18, with conformationally modified albumins. Presence in many cells and tissues with a possible role in catabolism.

1992 • 147 citations

Protein Kinase Cα-Induced p115RhoGEF Phosphorylation Signals Endothelial Cytoskeletal Rearrangement

2003 • 147 citations

VEGF transiently disrupts gap junctional communication in endothelial cells

2001 • 147 citations

IQGAP1 and Calmodulin Modulate E-cadherin Function

1999 • 147 citations

Cyclic AMP Blocks Bacterial Lipopolysaccharide-Induced Myosin Light Chain Phosphorylation in Endothelial Cells Through Inhibition of Rho/Rho Kinase Signaling

2000 • 146 citations

Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2

2000 • 146 citations

Albumin interacts specifically with a 60-kDa microvascular endothelial glycoprotein.

1988 • 146 citations

Loss of Caveolin-1 Polarity Impedes Endothelial Cell Polarization and Directional Movement

2004 • 145 citations

Role of Urokinase Receptor and Caveolin in Regulation of Integrin Signaling

1999 • 145 citations

Histamine and interstitial Pulmonary Edema in the Dog

1971 • 144 citations

S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin

2003 • 143 citations

Gα _q and Gβγ Regulate PAR-1 Signaling of Thrombin-Induced NF-κB Activation and ICAM-1 Transcription in Endothelial Cells

2002 • 143 citations

Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration

1998 • 143 citations

Tracking SNARE Complex Formation in Live Endocrine Cells

2004 • 142 citations

Isolation and characterization of a cell surface albumin-binding protein from vascular endothelial cells.

1996 • 142 citations

Identification of Src Phosphorylation Sites in the Catenin p120

2001 • 142 citations

A dominant mutant of occludin disrupts tight junction structure and function

1999 • 142 citations

Expression of PKA inhibitor (PKI) gene abolishes cAMPmediated protection to endothelial barrier dysfunction

1999 • 141 citations

Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells

2002 • 140 citations

Endothelial plasmalemmal vesicles have a characteristic striped bipolar surface structure.

1985 • 140 citations

Role of a glycocalyx on coronary arteriole permeability to proteins: evidence from enzyme treatments

2000 • 140 citations

Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice

2000 • 139 citations

Caveolin Transfection Results in Caveolae Formation but Not Apical Sorting of Glycosylphosphatidylinositol (GPI)-anchored Proteins in Epithelial Cells

1998 • 139 citations

Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cells

1999 • 139 citations

Tumor necrosis factor alpha-induced pulmonary vascular endothelial injury

1989 • 139 citations

Activated Neutrophils Induce Hyperpermeability and Phosphorylation of Adherens Junction Proteins in Coronary Venular Endothelial Cells

1999 • 138 citations

The protein tyrosine phosphatase Shp-2 regulates RhoA activity

2000 • 138 citations

Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization

2004 • 138 citations

The Effect of the Endothelial-Cell Glycocalyx on the Motion of Red Blood Cells through Capillaries

1998 • 138 citations

Redox Regulation of Reactive Oxygen Species-Induced p38 MAP Kinase Activation and Barrier Dysfunction in Lung Microvascular Endothelial Cells

2003 • 137 citations

Plasmalemmal vesicles represent the large pore system of continuous microvascular endothelium

1993 • 137 citations

Positive Role of IQGAP1, an Effector of Rac1, in Actin-Meshwork Formation at Sites of Cell-Cell Contact

2003 • 137 citations

LIM Kinase 1 Coordinates Microtubule Stability and Actin Polymerization in Human Endothelial Cells

2005 • 137 citations

Characterization of the Interaction between Protein 4.1R and ZO-2

2000 • 136 citations

Small Interfering RNA-mediated Down-regulation of Caveolin-1 Differentially Modulates Signaling Pathways in Endothelial Cells

2004 • 136 citations

CRKL Links p210BCR/ABL with Paxillin in Chronic Myelogenous Leukemia Cells

1995 • 136 citations

Oxidant injury of cells.

1987 • 135 citations

VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function

2004 • 135 citations

Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domain.

1995 • 135 citations

Protein kinase involved in lung injury susceptibility: Evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment

2003 • 135 citations

Requirement of Rac activity for maintenance of capillary endothelial barrier properties

2004 • 134 citations

Baculovirus-based Expression of Mammalian Caveolin in Sf21 Insect Cells

1996 • 134 citations

Modulation of extracellular matrix proteins by endothelial cells undergoing angiogenesis in vitro.

1991 • 134 citations

The Intersectin 2 Adaptor Links Wiskott Aldrich Syndrome Protein (WASp)-mediated Actin Polymerization to T Cell Antigen Receptor Endocytosis

2001 • 133 citations

Effects of bradykinin and angiotensin II on intracellular Ca2+ dynamics in endothelial cells

1987 • 133 citations

Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells

2001 • 132 citations

Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II

2000 • 132 citations

Transforming growth factor-β inhibition of proteasomal activity: a potential mechanism of growth arrest

2003 • 132 citations

Endothelial Myosin Light Chain Kinase Regulates Neutrophil Migration Across Human Umbilical Vein Endothelial Cell Monolayer

1998 • 131 citations

Physical and Functional Interaction of Filamin (Actin-binding Protein-280) and Tumor Necrosis Factor Receptor-associated Factor 2

2000 • 131 citations

TUMOUR NECROSIS FACTOR α ALTERS THE EXPRESSION OF CONNEXIN43, CONNEXIN40, AND CONNEXIN37, IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS

1998 • 131 citations

Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors

2002 • 130 citations

Involvement of site‐specific FAK phosphorylation in sphingosine‐1 phosphate‐ and thrombin‐induced focal adhesion remodeling: role of Src and GIT

2003 • 130 citations

Vascular Endothelial Growth Factor Gene Expression in Human Fetal Lung In Vitro

1999 • 129 citations

The Role of the Hemostatic System in Tumor Growth, Metastasis, and Angiogenesis: Tissue factor is a Bifunctional Molecule Capable of Inducing Both Fibrin Deposition and Angiogenesis in Cancer

2001 • 129 citations

Integrins in vascular development

1999 • 129 citations

VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: A pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions

1998 • 129 citations

Caveolin-1 Expression and Caveolae Biogenesis during Cell Transdifferentiation in Lung Alveolar Epithelial Primary Cultures

1999 • 128 citations

Activation of NF-κB induced by H₂O₂and TNF-α and its effects on ICAM-1 expression in endothelial cells

2000 • 128 citations

Permeability of human endothelial monolayers: effect of vasoactive agonists and cAMP

1989 • 128 citations

Transient venular permeability increase and endothelial gap formation induced by histamine

1992 • 128 citations

ROCK mediates thrombin's endothelial barrier dysfunction

2000 • 127 citations

Kinin receptors

1998 • 127 citations

NEM inhibits transcytosis, endocytosis, and capillary permeability: implication of caveolae fusion in endothelia

1995 • 127 citations

Occludin Modulates Transepithelial Migration of Neutrophils

2000 • 126 citations

Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression

2004 • 126 citations

PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated β-catenin

1999 • 126 citations

The cAMP-Epac-Rap1 Pathway Regulates Cell Spreading and Cell Adhesion to Laminin-5 through the α3β1 Integrin but Not the α6β4 Integrin

2004 • 125 citations

Tissue Factor-Dependent Vascular Endothelial Growth Factor Production by Human Fibroblasts in Response to Activated Factor VII

1998 • 125 citations

Bilayers merge even when exocytosis is transient

2004 • 125 citations

Cdc42 Regulates the Restoration of Endothelial Barrier Function

2003 • 125 citations

Capacitative calcium entry is inhibited in vascular endothelial cells by disruption of cytoskeletal microfilaments

1997 • 125 citations

A Novel Interaction between Kinesin and p120 Modulates p120 Localization and Function

2004 • 125 citations

Rho and rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice

2002 • 124 citations

Microtubule dynamics in living cells

1998 • 124 citations

Pentosan Polysulfate Decreases Proliferation and Net Extracellular Matrix Production in Mouse Mesangial Cells

1999 • 124 citations

Stable Expression of the Human Kinin B1 Receptor in Chinese Hamster Ovary Cells

1997 • 123 citations

Deciphering Vascular Endothelial Cell Growth Factor/Vascular Permeability Factor Signaling to Vascular Permeability

2002 • 123 citations

The Membrane-spanning Domains of Caveolins-1 and -2 Mediate the Formation of Caveolin Hetero-oligomers

1999 • 123 citations

The Human Proteinase-activated Receptor-3 (PAR-3) Gene

1998 • 122 citations

Multiple Domains in Caveolin-1 Control Its Intracellular Traffic

2000 • 122 citations

Mechanisms for Reversible Regulation between G13 and Rho Exchange Factors

2002 • 122 citations

Caveolin-1 Binding to Endoplasmic Reticulum Membranes and Entry into the Regulated Secretory Pathway Are Regulated by Serine Phosphorylation

2001 • 122 citations

Receptor Protein-tyrosine Phosphatase RPTPμ Binds to and Dephosphorylates the Catenin p120

2000 • 122 citations

Endothelial transport of macromolecules: transcytosis and endocytosis. A look from cell biology.

1991 • 122 citations

Activation of protein kinase C pathway contributes to hydrogen peroxide-induced increase in endothelial permeability.

1992 • 122 citations

A Molecular Sensor Detects Signal Transduction from Caveolae in Living Cells

2002 • 122 citations

Cell surface expression of receptor protein tyrosine phosphatase RPTP mu is regulated by cell-cell contact.

1995 • 121 citations

Organization of choroid plexus epithelial and endothelial cell tight junctions and regulation of claudin-1, -2 and -5 expression by protein kinase C

2000 • 121 citations

Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor‐associated microvessels in man and animals

2002 • 121 citations

Endothelial Gaps as Sites for Plasma Leakage in Inflammation

1999 • 121 citations

Mildly Oxidized Low Density Lipoprotein Induces Contraction of Human Endothelial Cells through Activation of Rho/Rho Kinase and Inhibition of Myosin Light Chain Phosphatase

1999 • 120 citations

Ezrin Interacts with Focal Adhesion Kinase and Induces Its Activation Independently of Cell-matrix Adhesion

2001 • 120 citations

Modulation of substrate adhesion dynamics via microtubule targeting requires kinesin-1

2002 • 120 citations

RhoA inactivation enhances endothelial barrier function

1999 • 120 citations

Structural Elements, Mechanism, and Evolutionary Convergence of Rho Protein−Guanine Nucleotide Exchange Factor Complexes

2003 • 120 citations

An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin [see comments]

1989 • 119 citations

Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and β-catenin

2002 • 119 citations

Paradoxical cAMP-Induced Lung Endothelial Hyperpermeability Revealed by Pseudomonas aeruginosa ExoY

2004 • 119 citations

Identification of albumin-binding proteins in capillary endothelial cells.

1988 • 118 citations

Palmitoylation of Caveolin-1 at a Single Site (Cys-156) Controls Its Coupling to the c-Src Tyrosine Kinase

2001 • 118 citations

Protein kinase C-ζ mediates TNF-α-induced ICAM-1 gene transcription in endothelial cells

2000 • 118 citations

Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase

2000 • 118 citations

Focal Adhesion Kinase Is Required for Blood Vessel Morphogenesis

2003 • 117 citations

Role of myosin light-chain phosphorylation in endothelial cell retraction

1993 • 117 citations

Oxidant-mediated activation of phospholipase A2 in pulmonary endothelium

1989 • 116 citations

Mechanisms of pulmonary edema induced by tumor necrosis factor-alpha.

1990 • 116 citations

Differential Actions of PAR ₂ and PAR ₁ in Stimulating Human Endothelial Cell Exocytosis and Permeability

2003 • 116 citations

The effect of altering the external calcium concentration and a calcium channel blocker, verapamil, on microvascular leaky sites and dextran clearance in the hamster cheek pouch

1984 • 116 citations

Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo

2004 • 115 citations

Hypoxia/Reoxygenation increases the permeability of endothelial cell monolayers: Role of oxygen radicals

1990 • 115 citations

Involvement of microtubules and Rho pathway in TGF‐β1‐induced lung vascular barrier dysfunction

2005 • 115 citations

Effect of the endothelial surface layer on transmission of fluid shear stress to endothelial cells

2001 • 114 citations

Modulation of gelsolin function. Activation at low pH overrides Ca2+ requirement.

1993 • 114 citations

SNARE regulators: matchmakers and matchbreakers

2003 • 113 citations

Increased permeability of microcarrier-cultured endothelial monolayers in response to histamine and thrombin. A model for the in vitro study of increased vasopermeability.

1986 • 113 citations

Gap junctions in human umbilical cord endothelial cells contain multiple connexins

1997 • 112 citations

Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy

2000 • 112 citations

Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability

1997 • 112 citations

KDR Stimulates Endothelial Cell Migration through Heterotrimeric G Protein Gq/11-mediated Activation of a Small GTPase RhoA

2002 • 112 citations

Identification of the homophilic binding site of the receptor protein tyrosine phosphatase PTP mu.

1994 • 112 citations

Intracellular Cholesterol Transport in Synchronized Human Skin Fibroblasts

1999 • 112 citations

Measurement of Material Extravasation in Microvascular Networks Using Fluorescence Video-Microscopy

1993 • 112 citations

Cell–Substrate Contact: Another Factor May Influence Transepithelial Electrical Resistance of Cell Layers Cultured on Permeable Filters

1999 • 111 citations

Ca ²⁺ Waves in Lung Capillary Endothelium

1996 • 111 citations

Transport of macromolecules through microvascular walls

1996 • 111 citations

Reoxygenation of endothelial cells increases permeability by oxidant-dependent mechanisms.

1992 • 110 citations

Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins.

1993 • 110 citations

p38 MAP kinase-dependent regulation of endothelial cell permeability

2004 • 110 citations

Ubiquitously Expressed Dynamin-II Has a Higher Intrinsic GTPase Activity and a Greater Propensity for Self-assembly Than Neuronal Dynamin-I

1997 • 110 citations

Caveolin-1 Interacts Directly with Dynamin-2

2005 • 110 citations

Annealing of Gelsolin-severed Actin Fragments by Tropomyosin in the Presence of Ca2+

1989 • 110 citations

Effect of capillary pressure and plasma protein on development of pulmonary edema

1967 • 109 citations

Size and charge selective permeability defects induced in glomerular basement membrane by a polycation

1984 • 109 citations

Receptor and G protein-mediated responses to thrombin in HEL cells.

1991 • 109 citations

Evidence for the role of alveolar epithelial gp60 in active transalveolar albumin transport in the rat lung

2001 • 109 citations

Gene and Locus Structure and Chromosomal Localization of the Protease-activated Receptor Gene Family

1998 • 109 citations

Microtubule structure and dynamics

1997 • 108 citations

Protein kinase C-α mediates endothelial barrier dysfunction induced by TNF-α

2000 • 108 citations

Effects of Shear Stress on Glycosaminoglycan Synthesis in Vascular Endothelial Cells^a

1994 • 107 citations

Embryonic implantation and leukocyte transendothelial migration: different processes with similar players?

2005 • 107 citations

Regulation of Endothelial Barrier Function by the cAMP-Dependent Protein Kinase

2000 • 107 citations

Control of cAMP in lung endothelial cell phenotypes. Implications for control of barrier function

1999 • 107 citations

The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation

2003 • 106 citations

Regulation of actin dynamics is critical for endothelial barrier functions

2004 • 106 citations

Interaction of serum proteins with lung endothelial glycocalyx: its effect on endothelial permeability

1984 • 105 citations

Biochemical Regulation of the Nonmuscle Myosin Light Chain Kinase Isoform in Bovine Endothelium

1998 • 105 citations

Specific albumin binding to microvascular endothelium in culture

1988 • 103 citations

Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation

2000 • 103 citations

Integrated control of lung fluid balance

2004 • 103 citations

Transcytosis in the continuous endothelium of the myocardial microvasculature is inhibited by N-ethylmaleimide.

1994 • 102 citations

Phalloidin enhances endothelial barrier function and reduces inflammatory permeability in vitro

1988 • 102 citations

A 96-kDa gelatinase induced by TNF-alpha contributes to increased microvascular endothelial permeability

1993 • 101 citations

PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction

2003 • 101 citations

Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells

2002 • 101 citations

Inhibition of Endothelial Wound Repair by Dominant Negative Connexin Inhibitors

2001 • 101 citations

Dynamin Assembles into Spirals under Physiological Salt Conditions upon the Addition of GDP and γ-Phosphate Analogues

1997 • 100 citations

Protease-activated Receptor-1 Activation of Endothelial Cells Induces Protein Kinase Cα-dependent Phosphorylation of Syntaxin 4 and Munc18c

2004 • 100 citations

Regulation of endothelial cell gap formation and barrier function by myosin-associated phosphatase activities

1995 • 100 citations

Cytoskeletal changes induced by GRAF, the <u>G</u>TPase <u>r</u>egulator <u>a</u>ssociated with <u>f</u>ocal adhesion kinase, are mediated by Rho

1999 • 100 citations

Gβγ Activation of Src Induces Caveolae-mediated Endocytosis in Endothelial Cells

2004 • 100 citations

Modulation of Apoptotic Cell Death by Extracellular Matrix Proteins and a Fibronectin-Derived Antiadhesive Peptide

1998 • 99 citations

Actin-binding proteins. 1: Spectrin super family.

1995 • 99 citations

Novel interaction of cortactin with endothelial cell myosin light chain kinase

2002 • 99 citations

Stimulated neutrophils induce myosin light chain phosphorylation and isometric tension in endothelial cells

1997 • 99 citations

Focal and Regional Variations in the Composition of the Glycocalyx of Large Vessel Endothelium

1994 • 98 citations

Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin

2002 • 98 citations

Intersectin Regulates Fission and Internalization of Caveolae in Endothelial Cells

2003 • 98 citations

Osmotic reflextion coefficients of capillary walls to low molecular weight hydrophilic solutes measured in single perfused capillaries of the frog mesentery.

1976 • 97 citations

A Mitosis-specific Phosphorylation of the Gap Junction Protein Connexin43 in Human Vascular Cells: Biochemical Characterization and Localization

1997 • 97 citations

Functional and morphological studies of protein transcytosis in continuous endothelia

2004 • 96 citations

Reactive oxygen species activate focal adhesion kinase, paxillin and P130CAS tyrosine phosphorylation in endothelial cells

1998 • 96 citations

Essential Role of Junctional Adhesion Molecule-1 in Basic Fibroblast Growth Factor–Induced Endothelial Cell Migration

2003 • 96 citations

Plasmalemmal vesicles function as transcytotic carriers for small proteins in the continuous endothelium

1997 • 96 citations

Identification and cloning of two species of cadherins in bovine endothelial cells.

1990 • 96 citations

Transport Pathways in Capillaries-In Search of Pores

1980 • 96 citations

Reversibility of increased microvessel permeability in response to VE-cadherin disassembly

2000 • 95 citations

Tumor Necrosis Factor-α Induces Nuclear Factor-κB-dependent TRPC1 Expression in Endothelial Cells

2003 • 95 citations

Compounds that increase cAMP prevent ischemia-reperfusion pulmonary capillary injury

1992 • 95 citations

Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells

1996 • 95 citations

Gap-junctional coupling between neutrophils and endothelial cells: a novel modulator of transendothelial migration

2003 • 95 citations

The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain

2000 • 94 citations

Role of VASP in reestablishment of epithelial tight junction assembly after Ca²⁺ switch

2002 • 94 citations

The Integration of Cell Adhesion with Gene Expression: The Role of β-Catenin

2000 • 93 citations

Scanning electron microscopy of normal rat liver: The surface structure of its cells and tissue components

1975 • 93 citations

Human microvascular endothelial cells express integrin‐related complexes that mediate adhesion to the extracellular matrix

1989 • 93 citations

Differentiation of blood-brain barrier endothelial cells.

1998 • 93 citations

Expression of zonula occludens and adherens junctional proteins in human venous and arterial endothelial cells: role of occludin in endothelial solute barriers.

1998 • 92 citations

Adhesion-dependent control of matrix metalloproteinase-2 activation in human capillary endothelial cells

2000 • 92 citations

Bacterial lipopolysaccharide induces actin reorganization, intercellular gap formation, and endothelial barrier dysfunction in pulmonary vascular endothelial cells: Concurrent F‐actin depolymerization and new actin synthesis

1993 • 92 citations

Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury

2000 • 92 citations

The sensitivity of versican from rabbit lung to gelatinase A (MMP‐2) and B (MMP‐9) and its involvement in the development of hydraulic lung edema

1999 • 91 citations

The Role of p38 MAP Kinase in Tumor Necrosis Factor-Induced Redistribution of Vascular Endothelial Cadherin and Increased Endothelial Permeability

2002 • 91 citations

Differential regulation of diverse physiological responses to VEGF in pulmonary endothelial cells

2001 • 91 citations

Dominant regulation of interendothelial cell gap formation by calcium-inhibited type 6 adenylyl cyclase

2002 • 91 citations

Involvement of IQGAP1, an Effector of Rac1 and Cdc42 GTPases, in Cell-Cell Dissociation during Cell Scattering

2001 • 91 citations

The Activity of the GTPase-activating Protein CdGAP Is Regulated by the Endocytic Protein Intersectin

2002 • 90 citations

Dominant role of cAMP in regulation of microvessel permeability

2000 • 90 citations

GIT1 Activates p21-Activated Kinase through a Mechanism Independent of p21 Binding

2004 • 89 citations

Role of CaM kinase II and ERK activation in thrombin-induced endothelial cell barrier dysfunction

2003 • 89 citations

Intersectin Can Regulate the Ras/MAP Kinase Pathway Independent of Its Role in Endocytosis

2000 • 89 citations

Histamine alters endothelial barrier function at cell-cell and cell-matrix sites

2000 • 88 citations

Role of cAMP-dependent protein kinase A activity in endothelial cell cytoskeleton rearrangement

2001 • 88 citations

Endothelial Transcytotic Machinery Involves Supramolecular Protein–Lipid Complexes

2001 • 88 citations

Protein kinase C modifications of VE-cadherin, p120, and β-catenin contribute to endothelial barrier dysregulation induced by thrombin

2003 • 88 citations

Morphological and physiological correlation of bradykinin-induced macromolecular efflux

1979 • 88 citations

cAMP protects endothelial barrier functions by preventing Rac-1 inhibition

2004 • 88 citations

The 29-kDa proteins phosphorylated in thrombin-activated human platelets are forms of the estrogen receptor-related 27-kDa heat shock protein.

1991 • 88 citations

O2 radicals mediate reperfusion lung injury in ischemic O2-ventilated canine pulmonary lobe

1987 • 85 citations

Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury

2003 • 85 citations

Activation of dynamin GTPase is a result of positive cooperativity.

1994 • 85 citations

Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function

2002 • 85 citations

Mechanisms of Phospholipase C-Regulated Calcium Entry

2004 • 85 citations

Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro.

1996 • 85 citations

Distinct bradykinin receptors mediate stimulation of prostaglandin synthesis by endothelial cells and fibroblasts.

1988 • 84 citations

Histamine and inositol phosphate accumulation in endothelium: cAMP and a G protein

1989 • 83 citations

Endothelial Albumin Binding Proteins Are Membrane-associated Components Exposed on the Cell Surface

1989 • 83 citations

Rac regulates integrin-mediated endothelial cell adhesion and migration on laminin-8

2003 • 83 citations

Evidence for endothelial cell-mediated regulation of macromolecular permeability by postcapillary venules.

1986 • 83 citations

Ca(2+)-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function.

1995 • 83 citations

Endothelial Barrier Strengthening by Activation of Focal Adhesion Kinase

2003 • 82 citations

Physiology and pathophysiology of the vascular wall / [Physiologie et pathophysiologie de la paroi vasculaire] Mechanisms of increased endothelial permeability

1996 • 82 citations

Standing up to the challenge of standing: a siphon does not support cerebral blood flow in humans

2004 • 82 citations

Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability

2000 • 82 citations

Oxygen-dependent reperfusion injury in the isolated rat lung

1992 • 81 citations

Protein kinase inhibitor prevents pulmonary edema in response to H2O2

1989 • 81 citations

Porcine aortic endothelial gap junctions: identification and permeation by caged InsP3

1996 • 81 citations

G13α-mediated PYK2 Activation

2000 • 81 citations

The nitric oxide pathway modulates hemangioblast activity of adult hematopoietic stem cells

2004 • 81 citations

Critical steps in cellular fatty acid uptake and utilization

2002 • 81 citations

Myosin light chain phosphorylation: modulation of basal and agonist-stimulated venular permeability

1997 • 81 citations

AC133 Antigen Expression Is Not Restricted to Acute Myeloid Leukemia Blasts But Is Also Found on Acute Lymphoid Leukemia Blasts and on a Subset of CD34+ B-Cell Precursors

1999 • 81 citations

CdGAP, a Novel Proline-rich GTPase-activating Protein for Cdc42 and Rac

1998 • 81 citations

Cloning of JAM-2 and JAM-3: an Emerging Junctional Adhesion Molecular Family

2000 • 80 citations

Tissue factor and angiogenesis in cancer

2002 • 80 citations

Role of catenins in the development of gap junctions in rat cardiomyocytes

2003 • 80 citations

Roles of Microtubule Dynamics and Small GTPase Rac in Endothelial Cell Migration and Lamellipodium Formation under Flow

2002 • 80 citations

Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin

1989 • 80 citations

Oxygen radical-induced mitochondrial DNA damage and repair in pulmonary vascular endothelial cell phenotypes

2001 • 79 citations

Single capillary permeability to proteins having similar size but different charge

1988 • 79 citations

Mechanism of the sustained action of histamine and bradykinin on transport of large molecules across capillary walls in the dog paw

1974 • 79 citations

Openings Through Endothelial Cells Associated with Increased Microvascular Permeability

1999 • 79 citations

Involvement of Ca2+ in the H2O2-induced increase in endothelial permeability

1996 • 79 citations

Hydrogen peroxide alters the physical state and function of the plasma membrane of pulmonary artery endothelial cells

1991 • 78 citations

Conformational Activation of Radixin by G13 Protein α Subunit

2000 • 78 citations

MAP kinases in lung endothelial permeability induced by microtubule disassembly

2005 • 78 citations

Src-dependent, neutrophil-mediated vascular hyperpermeability and β-catenin modification

2002 • 78 citations

Two α subunits of the G_q class of G proteins stimulate phosphoinositide phospholipase C‐β1 activity

1991 • 77 citations

Divergent Effects of Platelet-Endothelial Cell Adhesion Molecule-1 and β3 Integrin Blockade on Leukocyte Transmigration In Vivo

2000 • 77 citations

Regulation of Calcium-sensitive Tyrosine Kinase Pyk2 by Angiotensin II in Endothelial Cells

2000 • 76 citations

In Vivo Functional Analysis of the Ras Exchange Factor Son of Sevenless

1995 • 76 citations

PTHrP stimulated by the calcium-sensing receptor requires MAP kinase activation

2003 • 76 citations

Albumin modulation of capillary permeability: test of an adsorption mechanism

1985 • 76 citations

Diperoxovanadate alters endothelial cell focal contacts and barrier function: role of tyrosine phosphorylation

2000 • 76 citations

Vascular segmental permeabilities at high peak inflation pressure in isolated rat lungs

2002 • 76 citations

Thrombin-mediated Focal Adhesion Plaque Reorganization in Endothelium: Role of Protein Phosphorylation

1997 • 76 citations

Isoproterenol reduces thrombin-induced pulmonary endothelial permeability in vitro

1989 • 76 citations

Desmoplakin expression and organization at human umbilical vein endothelial cell-to-cell junctions

1996 • 76 citations

DNA Strand Break Formation Following Exposure of Bovine Pulmonary Artery and Aortic Endothelial Cells to Reactive Oxygen Products

1991 • 75 citations

Signal transduction pathways for B1 and B2 bradykinin receptors in bovine pulmonary artery endothelial cells.

1995 • 75 citations

Thrombin and bradykinin initiate discrete endothelial solute permeability mechanisms

1993 • 75 citations

Analbuminemia: three cases resulting from different point mutations in the albumin gene.

1994 • 75 citations