Tensegrity I. Cell structure and hierarchical systems biology

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

1993 • 2,947 citations

Cell locomotion and focal adhesions are regulated by substrate flexibility

1997 • 2,930 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

2001 • 2,089 citations

Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape.

1993 • 1,765 citations

Direct Mechanical Measurements of the Elasticity of Single DNA Molecules by Using Magnetic Beads

1992 • 1,755 citations

A tension-based theory of morphogenesis and compact wiring in the central nervous system

1997 • 1,647 citations

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

1997 • 1,572 citations

Focal Contacts as Mechanosensors

2001 • 1,390 citations

Silicone Rubber Substrata: A New Wrinkle in the Study of Cell Locomotion

1980 • 1,333 citations

Scaling the Microrheology of Living Cells

2001 • 1,221 citations

Extracellular Matrix Rigidity Causes Strengthening of Integrin–Cytoskeleton Linkages

1997 • 1,218 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton

1993 • 1,124 citations

Elasticity of Semiflexible Biopolymer Networks

1995 • 1,019 citations

Muscles, Reflexes, and Locomotion

1984 • 1,019 citations

Traction fields, moments, and strain energy that cells exert on their surroundings

2002 • 1,008 citations

Molecular architecture of basement membranes

1990 • 937 citations

Tensegrity II. How structural networks influence cellular information processing networks

2003 • 818 citations

The Cytoskeleton and Cell Signaling: Component Localization and Mechanical Coupling

1998 • 783 citations

Apparent viscosity and cortical tension of blood granulocytes determined by micropipet aspiration

1989 • 771 citations

The structural and mechanical complexity of cell-growth control

1999 • 769 citations

Local Measurements of Viscoelastic Parameters of Adherent Cell Surfaces by Magnetic Bead Microrheometry

1998 • 709 citations

Mechanical behavior in living cells consistent with the tensegrity model

2001 • 705 citations

Viscoelastic properties of vimentin compared with other filamentous biopolymer networks.

1991 • 694 citations

Single-Molecule Biomechanics with Optical Methods

1999 • 667 citations

Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells

2002 • 664 citations

Filament organization revealed in platinum replicas of freeze-dried cytoskeletons.

1980 • 662 citations

Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: three-dimensional organization and protein composition.

1984 • 545 citations

The Architecture of Life

1998 • 545 citations

Cellular control lies in the balance of forces

1998 • 530 citations

Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension

1994 • 528 citations

Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex.

1995 • 503 citations

Fibronectin controls capillary endothelial cell growth by modulating cell shape.

1990 • 498 citations

Self-polarization and directional motility of cytoplasm

1999 • 493 citations

Actomyosin-based Retrograde Flow of Microtubules in the Lamella of Migrating Epithelial Cells Influences Microtubule Dynamic Instability and Turnover and Is Associated with Microtubule Breakage and Treadmilling

1997 • 470 citations

Impaired mechanical stability, migration and contractile capacity in vimentin deficient fibroblasts

1998 • 469 citations

Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study

1992 • 456 citations

Actin, alpha-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells.

1976 • 454 citations

Cell Spreading and Lamellipodial Extension Rate Is Regulated by Membrane Tension

2000 • 454 citations

Cellular Tensegrity: Exploring How Mechanical Changes in the Cytoskeleton Regulate Cell Growth, Migration, and Tissue Pattern during Morphogenesis

1994 • 428 citations

Visualization of the hexagonal lattice in the erythrocyte membrane skeleton.

1987 • 405 citations

The function of intermediate filaments in cell shape and cytoskeletal integrity.

1996 • 373 citations

Simulations of the Erythrocyte Cytoskeleton at Large Deformation. II. Micropipette Aspiration

1998 • 346 citations

Cell shape, cytoskeletal mechanics, and cell cycle control in angiogenesis

1995 • 339 citations

Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated.

1993 • 336 citations

Fibroblast contractility and actin organization are stimulated by microtubule inhibitors

1989 • 303 citations

Contribution of intermediate filaments to cell stiffness, stiffening, and growth

2000 • 296 citations

Tension and compression in the cytoskeleton of PC-12 neurites. II: Quantitative measurements.

1988 • 288 citations

NUANCE, a giant protein connecting the nucleus and actin cytoskeleton

2002 • 285 citations

Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape

1992 • 274 citations

Basal lamina of embryonic salivary epithelia. Production by the epithelium and role in maintaining lobular morphology.

1977 • 273 citations

Vinculin Promotes Cell Spreading by Mechanically Coupling Integrins to the Cytoskeleton

1997 • 267 citations

Theoretical estimates of mechanical properties of the endothelial cell cytoskeleton

1996 • 265 citations

The cytomechanics of axonal elongation and retraction.

1989 • 262 citations

Change of residual strains in arteries due to hypertrophy caused by aortic constriction.

1989 • 257 citations

Movement and self-control in protein assemblies. Quasi-equivalence revisited

1980 • 244 citations

Probing transmembrane mechanical coupling and cytomechanics using magnetic twisting cytometry

1995 • 236 citations

Is cytoskeletal tension a major determinant of cell deformability in adherent endothelial cells?

1998 • 234 citations

Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain.

1995 • 229 citations

Two distinct attachment sites for vimentin along the plasma membrane and the nuclear envelope in avian erythrocytes: a basis for a vectorial assembly of intermediate filaments.

1987 • 227 citations

Microtubules and microfilaments in newt neurulation

1971 • 225 citations

Tension and compression in the cytoskeleton of PC 12 neurites.

1985 • 224 citations

Residual strain in rat left ventricle.

1990 • 222 citations

Cell prestress. II. Contribution of microtubules

2002 • 220 citations

The riddle of morphogenesis: A question of solution chemistry or molecular cell engineering?

1993 • 219 citations

A Microstructural Approach to Cytoskeletal Mechanics based on Tensegrity

1996 • 218 citations

Analysis of Cell Mechanics in Single Vinculin-Deficient Cells Using a Magnetic Tweezer

2000 • 216 citations

Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton.

1996 • 212 citations

Tensegrity and mechanoregulation: from skeleton to cytoskeleton

1999 • 209 citations

Direct Observations of the Mechanical Behaviors of the Cytoskeleton in Living Fibroblasts

1999 • 205 citations

Role of basal lamina in neoplastic disorganization of tissue architecture.

1981 • 202 citations

Relationship Between Hypertension, Hypertrophy, and Opening Angle of Zero-Stress State of Arteries Following Aortic Constriction

1989 • 196 citations

Elementary Mechanics of the Endothelium of Blood Vessels

1993 • 182 citations

On the possible role of cytoskeletal filamentous networks in intracellular signaling: An approach based on percolation

1995 • 181 citations

Cytoskeletal Mechanics in Pressure-Overload Cardiac Hypertrophy

1997 • 180 citations

Analysis of the role of microfilaments and microtubules in acquisition of bipolarity and elongation of fibroblasts in hydrated collagen gels.

1984 • 177 citations

Rapid Induction and Isolation of Focal Adhesion Complexes

1993 • 174 citations

Opposing views on tensegrity as a structural framework for understanding cell mechanics

2000 • 173 citations

Mathematics and Tensegrity

1998 • 169 citations

Cytoskeletal Plasticity in Cells Expressing Neuronal Microtubule-Associated Proteins

1996 • 162 citations

Attachment and tension in the spindle assembly checkpoint

2002 • 160 citations

Tumor invasion and metastasis.

1986 • 156 citations

Models of cytoskeletal mechanics of adherent cells

2002 • 153 citations

Understanding dystrophinopathies: an inventory of the structural and functional consequences of the absence of dystrophin in muscles of the mdx mouse.

1999 • 153 citations

Mechanical continuity and reversible chromosome disassembly within intact genomes removed from living cells

1997 • 152 citations

Rigidity of Circulating Lymphocytes Is Primarily Conferred by Vimentin Intermediate Filaments

2001 • 149 citations

Acrosomal reaction of Thyone sperm. II. The kinetics and possible mechanism of acrosomal process elongation.

1982 • 143 citations

Amyloplast Sedimentation Dynamics in Maize Columella Cells Support a New Model for the Gravity-Sensing Apparatus of Roots

2001 • 139 citations

Spatiotemporal Analysis of Flow-Induced Intermediate Filament Displacement in Living Endothelial Cells

2001 • 138 citations

Cell structure and DNA organization.

1991 • 133 citations

Cytoplasmic rheology of passive neutrophils

1991 • 131 citations

Pharmacological activation changes stiffness of cultured human airway smooth muscle cells

1996 • 130 citations

The Role of Prestress and Architecture of the Cytoskeleton and Deformability of Cytoskeletal Filaments in Mechanics of Adherent Cells: a Quantitative Analysis

1999 • 130 citations

Tensile stress stimulates microtubule outgrowth in living cells

2002 • 127 citations

Extension of filopodia by motor‐dependent actin assembly

1992 • 127 citations

Three-dimensional structure of clathrin cages in ice.

1986 • 122 citations

Stereo immunofluorescence microscopy: I. Threedimensional arrangement of microfilaments, microtubules and tonofilaments

1978 • 122 citations

Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro.

1986 • 118 citations

A Cellular Tensegrity Model to Analyse the Structural Viscoelasticity of the Cytoskeleton

2002 • 110 citations

Dynamic features of microtubules as visualized by dark-field microscopy

1990 • 108 citations

Regulation of cytoskeletal mechanics and cell growth by myosin light chain phosphorylation

1998 • 105 citations

A Prestressed Cable Network Model of the Adherent Cell Cytoskeleton

2003 • 103 citations

Movement, stability and low back pain.

1998 • 100 citations

Control of microtubule assembly by extracellular matrix and externally applied strain

2001 • 91 citations

Molten Globule Structures in Milk Proteins: Implications for Potential New Structure-Function Relationships

2002 • 87 citations

A Quantitative Model of Cellular Elasticity Based on Tensegrity

1999 • 87 citations

A Tensegrity Structure With Buckling Compression Elements: Application to Cell Mechanics

1997 • 86 citations

Viscoelasticity in Wild-Type and Vinculin-Deficient (5.51) Mouse F9 Embryonic Carcinoma Cells Examined by Atomic Force Microscopy and Rheology

1996 • 82 citations

Intermediate Filaments May Prevent Buckling of Compressively Loaded Microtubules

1990 • 80 citations

A thermodynamic model for force integration and microtubule assembly during axonal elongation

1988 • 80 citations

Structure in art and in science

1965 • 79 citations

Traction fibre: Toward a “tensegral” model of the spindle

1997 • 79 citations

Microtubule assembly is regulated by externally applied strain in cultured smooth muscle cells

1998 • 78 citations

Cellular harmonic information transfer through a tissue tensegrity-matrix system

1991 • 78 citations

Flexural rigidity of singlet microtubules estimated from statistical analysis of their contour lengths and end-to-end distances

1983 • 77 citations

Biochemical consequences of mechanical forces generated by distention and distortion

1989 • 76 citations

Stiffening Response of a Cellular Tensegrity Model

1999 • 76 citations

A Tensegrity Model of the Cytoskeleton in Spread and Round Cells

1998 • 76 citations

Tensegrity architecture explains linear stiffening and predicts softening of living cells

2000 • 76 citations

Autonomous movements of cytoplasmic fragments.

1980 • 68 citations

Membrane Model of Endothelial Cells and Leukocytes. A Proposal for the Origin of a Cortical Stress

1995 • 68 citations

Role of cortical tension in fibroblast shape and movement

1987 • 65 citations

Opposing microtubule- and actin-dependent forces in the development and maintenance of structural polarity in retinal photoreceptors

1989 • 65 citations

Extracellular matrix allows PC12 neurite elongation in the absence of microtubules.

1990 • 60 citations

Effect of microtubule-destroying drugs on the spreading and shape of cultured epithelial cells

1985 • 59 citations

The origin of cellular life

2000 • 59 citations

Effect of the cytoskeletal prestress on the mechanical impedance of cultured airway smooth muscle cells

2002 • 59 citations

Snelson On The Tensegrity Invention

1996 • 57 citations

cAMP protects endothelial barrier function independent of inhibiting MLC₂₀-dependent tension development

1998 • 55 citations

Evidence that intermediate filament reorganization is induced by ATP-dependent contraction of the actomyosin cortex in permeabilized fibroblasts

1991 • 55 citations

Effects of microtubule disruption on force, velocity, stiffness and [Ca²⁺]_iin porcine coronary arteries

2000 • 54 citations

Extracellular matrix controls tubulin monomer levels in hepatocytes by regulating protein turnover.

1994 • 54 citations

Actin in polygonal arrays of microfilaments and sequestered actin bundles (SABs) in lens epithelial cells of rabbits and mice

1985 • 52 citations

Actin Cortex and Microtubular System in Morphogenesis: Cooperation and Competition

1987 • 52 citations

Cryoelectron microscopy of mammalian pyruvate dehydrogenase complex.

1991 • 50 citations

Putting neurons in the right places: local interactions in the genesis of retinal architecture

2002 • 44 citations

Studies onSaprolegnia feraxsuggest the general importance of the cytoplasm in determining hyphal morphology

1996 • 44 citations

A role for microtubule bundles in the morphogenesis of chicken erythrocytes.

1991 • 40 citations

The role of matrix contact and of cell-cell interactions in choriocarcinoma cell differentiation.

1996 • 30 citations

Cell motility as a chemotherapeutic target.

1991 • 28 citations

High-pressure freeze fixation reveals novel features during ontogenesis of the vegetative cell inLedebouriapollen: an ultrastructural and cytochemical study

1995 • 26 citations

Plugging into actin's architectonic socket

1997 • 25 citations

Tumor formation and malignant invasion: role of basal lamina

1982 • 24 citations

Interrelations Between Elastic Energy and Strain in a Tensegrity Model: Contribution to the Analysis of the Mechanical Response in Living Cells

2002 • 19 citations

Effects of microtubules and microfilaments on [Ca²⁺]_iand contractility in a reconstituted fibroblast fiber

2000 • 17 citations

Experimental tests of the cellular tensegrity hypothesis

2003 • 15 citations

Cell cytoskeleton and tensegrity

2002 • 15 citations

The tensegrity model applied to the lens: a hypothesis for the presence of the fiber cell ball and sockets

2000 • 14 citations

Possible involvement of microtubules in platelet-activating factor-induced increases in microvascular permeability in vitro

1993 • 13 citations

The relationship between domes and foams: application of geodesic mathematics to micelles

1984 • 12 citations

The cortical actomyosin system of cytochalasin D-treated lymphoblasts

1991 • 12 citations

Microscopic and Histochemical Manifestationsof Hyaline Cartilage Dynamics

1999 • 10 citations

Tensegrity model of pattern formation during cytokinesis of a ciliate, Paramecium: Effects of an inhibitor of phosphorylation, 6‐dimethylaminopurine, and of adenine

1995 • 9 citations

Can melatonin regulate the expression of prohormone convertase 1 and 2 genes via monomeric and dimeric forms of RZR/ROR nuclear receptor, and can melatonin influence the processes of embryogenesis or carcinogenesis by disturbing the proportion of cAMP and cGMP concentrations? Theoretic model of controlled apoptosis

2001 • 8 citations

Deleted Work

1955 • 0 citations