Sphingosine 1-Phosphate Stimulates Tyrosine Phosphorylation of Focal Adhesion Kinase and Chemotactic Motility of Endothelial Cells via the Gi Protein-Linked Phospholipase C Pathway

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

1997 • 1,162 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

1997 • 847 citations

G PROTEIN βγ SUBUNITS

1997 • 834 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

Focal adhesion kinase and associated proteins

1994 • 525 citations

Adhesion in cell migration

1995 • 520 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells

1997 • 477 citations

Fluid Shear Stress Activation of Focal Adhesion Kinase

1997 • 412 citations

Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2

1999 • 395 citations

Sphingosine 1-Phosphate Induces Angiogenesis: Its Angiogenic Action and Signaling Mechanism in Human Umbilical Vein Endothelial Cells

1999 • 359 citations

Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

1992 • 296 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5

1999 • 255 citations

Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts

1997 • 243 citations

Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness.

1992 • 223 citations

Comparison of Intrinsic Activities of the Putative Sphingosine 1-Phosphate Receptor Subtypes to Regulate Several Signaling Pathways in Their cDNA-transfected Chinese Hamster Ovary Cells

1999 • 219 citations

Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.

1994 • 214 citations

Signalling mechanisms in the regulation of vascular cell migration

1995 • 170 citations

Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate

1998 • 132 citations

cAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness.

1991 • 128 citations

Sphingosine 1-phosphate stimulates Rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts

1997 • 112 citations

The role of cyclic nucleotides in neutrophil migration

1996 • 82 citations

Sphingosine 1-Phosphate Regulates Melanoma Cell Motility through a Receptor-Coupled Extracellular Action and in a Pertussis Toxin-Insensitive Manner

1997 • 78 citations

Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases

1999 • 73 citations

Regulation of the RhoA pathway in human endothelial cell spreading on type IV collagen: role of calcium influx

1999 • 73 citations

Bombesin, Vasopressin, Lysophosphatidic Acid, and Sphingosylphosphorylcholine Induce Focal Adhesion Kinase Activation in Intact Swiss 3T3 Cells

1998 • 71 citations

Involvement of Focal Adhesion Kinase in Inhibition of Motility of Human Breast Cancer Cells by Sphingosine 1-Phosphate

1999 • 70 citations

Modulation of the chemotactic responsiveness of guinea pig neutrophils to hrIL-8 and fMLP

1994 • 15 citations