The protein tyrosine phosphatase Shp-2 regulates RhoA activity

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Protein tyrosine phosphatases in signal transduction

1997 • 766 citations

Bidirectional signaling between the cytoskeleton and integrins

1999 • 765 citations

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2

1997 • 474 citations

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

2000 • 429 citations

Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion

1998 • 390 citations

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus development

1995 • 330 citations

A Novel Regulator of p21-activated Kinases

1998 • 313 citations

Concerted Activity of Tyrosine Phosphatase SHP-2 and Focal Adhesion Kinase in Regulation of Cell Motility

1999 • 254 citations

Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2

1999 • 219 citations

Focal adhesion assembly

1997 • 212 citations

Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction

1994 • 182 citations

The Shp-2 Tyrosine Phosphatase Has Opposite Effects in Mediating the Activation of Extracellular Signal-regulated and c-Jun NH2-terminal Mitogen-activated Protein Kinases

1998 • 155 citations

Molecular Characterization of Specific Interactions between SHP-2 Phosphatase and JAK Tyrosine Kinases

1997 • 140 citations

Suramin Is an Active Site-directed, Reversible, and Tight-binding Inhibitor of Protein-tyrosine Phosphatases

1998 • 112 citations

Evidence for a Calpeptin-sensitive Protein-tyrosine Phosphatase Upstream of the Small GTPase Rho

1999 • 107 citations

Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2

1999 • 90 citations

Tyrosine Phosphatase SHP-2 Is Involved in Regulation of Platelet-derived Growth Factor-induced Migration

1999 • 64 citations