Regulation of vascular permeability by vascular endothelial growth factors

Handbook of Physiology.

1960 • 10,428 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Vascular endothelial growth factor (VEGF) and its receptors

1999 • 3,498 citations

Cardiovascular System

2000 • 2,962 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 1,670 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

1999 • 1,456 citations

The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA

1991 • 1,375 citations

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

1989 • 1,282 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 1,203 citations

Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.

1992 • 1,145 citations

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

1994 • 1,104 citations

Role of vascular endothelial growth factor in regulation of physiological angiogenesis

2001 • 1,068 citations

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

1999 • 1,044 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

2002 • 892 citations

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.

2000 • 848 citations

ENDOTHELIAL CONTRACTION INDUCED BY HISTAMINE-TYPE MEDIATORS

1969 • 841 citations

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

2001 • 816 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis

1999 • 752 citations

Vascular endothelial growth factor enhances atherosclerotic plaque progression

2001 • 711 citations

Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis.

1994 • 680 citations

Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family

2001 • 662 citations

A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines.

1986 • 641 citations

Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

1998 • 638 citations

The Carboxyl-terminal Domain(111–165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency

1996 • 615 citations

Control of hair growth and follicle size by VEGF-mediated angiogenesis

2001 • 603 citations

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1995 • 603 citations

Angiogenesis in skeletal and cardiac muscle

1992 • 595 citations

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.

1996 • 567 citations

An Introduction to Cardiovascular Physiology

1991 • 566 citations

Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas.

1993 • 564 citations

VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma.

2002 • 547 citations

Vascular reactions to histamine, histamine‐liberator and leukotaxine in the skin of guinea‐pigs

1952 • 535 citations

VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix

1997 • 529 citations

Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.

1990 • 503 citations

Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors

1996 • 497 citations

A Review of the Microcirculation of Adipose Tissue: Anatomic, Metabolic, and Angiogenic Perspectives

1997 • 490 citations

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

1995 • 480 citations

A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.

1995 • 480 citations

VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

1999 • 457 citations

Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries

1993 • 448 citations

Nitric Oxide Is an Upstream Signal of Vascular Endothelial Growth Factor-induced Extracellular Signal-regulated Kinase½ Activation in Postcapillary Endothelium

1998 • 436 citations

STUDIES ON INFLAMMATION. III. GROWING CAPILLARIES: THEIR STRUCTURE AND PERMEABILITY.

1963 • 430 citations

Characterization of Novel Vascular Endothelial Growth Factor (VEGF) Receptors on Tumor Cells That Bind VEGF165 via Its Exon 7-encoded Domain

1996 • 345 citations

Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells.

1991 • 325 citations

Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart

1998 • 320 citations

Studies on inflammation

1963 • 306 citations

Utilization of Distinct Signaling Pathways by Receptors for Vascular Endothelial Cell Growth Factor and Other Mitogens in the Induction of Endothelial Cell Proliferation

2000 • 285 citations

Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin.

1996 • 280 citations

Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells

1996 • 276 citations

Role of vascular endothelial growth factor in diabetic vascular complications

2000 • 272 citations

The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation

1996 • 266 citations

Placenta Growth Factor

2001 • 263 citations

Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A₂ in endothelial cells via p42/p44 mitogen‐activated protein kinase

1997 • 258 citations

Regulation of microvascular permeability by vascular endothelial growth factors*

2002 • 250 citations

VEGF induces NO-dependent hyperpermeability in coronary venules

1996 • 247 citations

Observations on changes in blood vascular endothelium in the living animal

1935 • 221 citations

Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in normal and atherosclerotic human arteries.

1997 • 203 citations

Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration.

2001 • 198 citations

Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms.

1997 • 196 citations

Thromboxane A2 Regulation of Endothelial Cell Migration, Angiogenesis, and Tumor Metastasis

2000 • 189 citations

Permeability characteristics of cultured endothelial cell monolayers

1988 • 185 citations

Pathways of Macromolecular Extravasation Across Microvascular Endothelium in Response to VPF/VEGF and Other Vasoactive Mediators

1999 • 180 citations

VEGF induces hyperpermeability by a direct action on endothelial cells

1998 • 178 citations

Vascular endothelial growth factor, a specific regulator of angiogenesis

1996 • 169 citations

Vascular endothelial growth factor increases hydraulic conductivity of isolated perfused microvessels

1996 • 167 citations

A DEVELOPMENT OF THE LANDIS TECHNIQUE FOR MEASURING THE FILTRATION COEFFICIENT OF INDIVIDUAL CAPILLARIES IN THE FROG MESENTERY

1974 • 166 citations

Interendothelial Junctions and their Role in the Control of Angiogenesis, Vascular Permeability and Leukocyte Transmigration

2001 • 163 citations

Characterization of the increase in vascular permeability induced by vascular permeability factor in vivo

1993 • 158 citations

Handbook of Physiology. Circulation. Vol. III, Sec. 2 W. F. Hamilton P. Dow

1966 • 158 citations

Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation.

2000 • 153 citations

Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway

1997 • 150 citations

The 121 amino acid isoform of vascular endothelial growth factor is more strongly tumorigenic than other splice variants in vivo

2000 • 149 citations

Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases.

2000 • 149 citations

Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability

1999 • 147 citations

Modulation of venular microvessel permeability by calcium influx into endothelial cells

1992 • 138 citations

Hypoxia-inducible factor-1α is regulated at the post-mRNA level

1997 • 134 citations

Vascular Endothelial Growth Factor and Microvascular Permeability

1999 • 131 citations

Steady‐state fluid filtration at different capillary pressures in perfused frog mesenteric capillaries.

1987 • 128 citations

Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea‐fig, mouse and rat: many are transcellular pores

1997 • 120 citations

VEGF-A induced hyperpermeability of blood-retinal barrier endothelium in vivo is predominantly associated with pinocytotic vesicular transport and not with formation of fenestrations

2000 • 113 citations

Transport of macromolecules through microvascular walls

1996 • 111 citations

Human Müller cells express VEGF183, a novel spliced variant of vascular endothelial growth factor.

1999 • 109 citations

Further characterization of malignant glioma-derived vascular permeability factor

1988 • 107 citations

Covalent dimerization of vascular permeability factor/vascular endothelial growth factor is essential for its biological activity. Evidence from Cys to Ser mutations

1994 • 103 citations

VEGF Stimulates MAPK through a Pathway That Is Unique for Receptor Tyrosine Kinases

1999 • 102 citations

Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium.

1998 • 94 citations

ZM323881, a Novel Inhibitor of Vascular Endothelial Growth Factor‐Receptor‐2 Tyrosine Kinase Activity

2002 • 86 citations

Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant

1999 • 85 citations

Intravital video-capillaroscopy for the study of the microcirculation in psoriasis

1992 • 81 citations

Structural mechanisms of acute VEGF effect on microvessel permeability

2003 • 74 citations

Induction of VEGF and VEGF receptor gene expression by hypoxia: Divergent regulation in vivo and in vitro

1997 • 68 citations

The distensibility of single capillaries and venules in the cat mesentery

1980 • 63 citations

Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins

2000 • 61 citations

Cytosolic calcium changes in endothelial cells induced by a protein product of human gliomas containing vascular permeability factor activity

1989 • 61 citations

Measurement of cytoplasmic calcium in single microvessels with increased permeability

1990 • 60 citations

Purification and biological properties of vasculotropin, a new angiogenic cytokine

1991 • 58 citations

Vascular endothelial growth factor increases Rana vascular permeability and compliance by different signalling pathways

2001 • 56 citations

Inflammatory changes in permeability and ultrastructure of single vessels in the frog mesenteric microcirculation.

1988 • 56 citations

Characterization of Signal Transduction Pathways in Human Bone Marrow Endothelial Cells

1997 • 55 citations

VEGF and ATP act by different mechanisms to increase microvascular permeability and endothelial [Ca²⁺]_i

2000 • 50 citations

Differential Effects of Vascular Endothelial Growth Factor-C and Placental Growth Factor-1 on the Hydraulic Conductivity of Frog Mesenteric Capillaries

2001 • 49 citations

THE PERMEABILITY OF BLOOD CAPILLARY SPROUTS AND NEWLY FORMED BLOOD CAPILLARIES AS COMPARED TO THAT OF OLDER BLOOD CAPILLARIES

1946 • 48 citations

The chronic effect of vascular endothelial growth factor on individually perfused frog mesenteric microvessels

1998 • 45 citations

Effect of VEGF on retinal microvascular endothelial hydraulic conductivity: the role of NO.

2000 • 44 citations

The influence of nimodipine on cerebral blood flow autoregulation and blood-brain barrier

1988 • 43 citations

In vivo mechanisms of vascular endothelial growth factor‐mediated increased hydraulic conductivity of Rana capillaries

2001 • 37 citations

Vascular Endothelial Growth Factor and Microvascular Permeability

1999 • 33 citations

Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant

1999 • 32 citations

Effect of indomethacin on capillary growth and microvasculature in chronically stimulated rat skeletal muscles

2000 • 25 citations

Formation and Regression of Capillary Sprouts in Corpora lutea of Immature Superstimulated Golden Hamsters

1987 • 23 citations

Expression of vascular permeability factor in glioblastoma specimens: correlation with tumor vascular endothelial surface and peritumoral edema.

2000 • 22 citations

Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins

2000 • 20 citations

Comparison of Diltiazem and Verapamil on Rat Microvascular Permeability

1997 • 8 citations

[A novel alternative splicing isoform of vascular endothelial growth factor gene in human beings].

2002 • 1 citations

Deleted Work

1955 • 0 citations