Role of CaM kinase II and ERK activation in thrombin-induced endothelial cell barrier dysfunction

The MAPK signaling cascade

1995 • 3,300 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

Cytoskeletal regulation of pulmonary vascular permeability

2001 • 954 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

The Multifunctional Calcium/Calmodulin-Dependent Protein Kinase: From Form to Function

1995 • 812 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Caldesmon, a novel regulatory protein in smooth muscle and nonmuscle actomyosin systems

1991 • 353 citations

Rho-Kinase–Mediated Contraction of Isolated Stress Fibers

2001 • 309 citations

Thrombin‐induced increase in albumin permeability across the endothelium

1986 • 307 citations

Biochemistry of Smooth Muscle Contraction

1996 • 306 citations

Involvement of myosin light-chain kinase in endothelial cell retraction.

1990 • 249 citations

Inhibition of smooth muscle actin-activated myosin Mg2+-ATPase activity by caldesmon.

1984 • 243 citations

Differential effect of MLC kinase in TNF-α-induced endothelial cell apoptosis and barrier dysfunction

2001 • 216 citations

Isolation and Contraction of the Stress Fiber

1998 • 203 citations

Myosin light chain kinase in endothelium: molecular cloning and regulation.

1997 • 200 citations

Caldesmon Inhibits Nonmuscle Cell Contractility and Interferes with the Formation of Focal Adhesions

1999 • 197 citations

Activation of phospholipases A2 and C in pig aortic endothelial cells synthesizing prostacyclin.

1982 • 182 citations

Ca(2+)-dependent phosphorylation of myosin light chain kinase decreases the Ca2+ sensitivity of light chain phosphorylation within smooth muscle cells

1994 • 176 citations

A role for MAP kinase in differentiated smooth muscle contraction evoked by α-adrenoceptor stimulation

1998 • 157 citations

Differential Regulation of Alternatively Spliced Endothelial Cell Myosin Light Chain Kinase Isoforms by p60Src

2001 • 150 citations

Regulation of permeabilized endothelial cell retraction by myosin phosphorylation

1991 • 149 citations

Phosphorylation of Caldesmon Prevents Its Interaction with Smooth Muscle Myosin

1989 • 138 citations

Identification of mitogen‐activated protein kinase phosphorylation sequences in mammalian h‐Caldesmon

1993 • 136 citations

Phosphorylation of smooth muscle caldesmon by mitogen-activated protein (MAP) kinase and expression of MAP kinase in differentiated smooth muscle cells

1992 • 131 citations

Differential detergent fractionation of isolated hepatocytes: Biochemical, immunochemical and two‐dimensional gel electrophoresis characterization of cytoskeletal and noncytoskeletal compartments

1994 • 128 citations

Phosphorylation of myosin light chain kinase by the multifunctional calmodulin-dependent protein kinase II in smooth muscle cells.

1992 • 127 citations

Serotonin activates the mitogen-activated protein kinase pathway in vascular smooth muscle: use of the mitogen-activated protein kinase kinase inhibitor PD098059.

1996 • 121 citations

Thrombin receptor activating peptides induce Ca²⁺ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet‐derived growth factor mRNA expression in cultured endothelium

1993 • 114 citations

A Role for Ca ²⁺ /Calmodulin-Dependent Protein Kinase II in the Mitogen-Activated Protein Kinase Signaling Cascade of Cultured Rat Aortic Vascular Smooth Muscle Cells

1997 • 110 citations

Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle.

1996 • 103 citations

Ca²⁺‐calmodulin‐dependent protein kinase II‐dependent activation of contractility in ferret aorta

2000 • 93 citations

Role of Ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction

2000 • 93 citations

Phosphorylation of Caldesmon by p21-activated Kinase

2000 • 86 citations

The inhibition of vascular smooth muscle cell migration by peptide and antibody antagonists of the alphavbeta3 integrin complex is reversed by activated calcium/calmodulin- dependent protein kinase II.

1997 • 86 citations

Inhibition of CaM kinase II activation and force maintenance by KN-93 in arterial smooth muscle

2000 • 85 citations

Phosphorylation of caldesmon by mitogen‐activated protein kinase with no effect on Ca2+ sensitivity in rabbit smooth muscle.

1995 • 77 citations

Diperoxovanadate alters endothelial cell focal contacts and barrier function: role of tyrosine phosphorylation

2000 • 76 citations

Activation of MAP kinases in airway smooth muscle

1997 • 73 citations

The effects of phosphorylation of smooth-muscle caldesmon

1987 • 73 citations

Cloning of cDNAs encoding human caldesmons

1992 • 71 citations

Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.

1992 • 71 citations

Regulation of endothelial cell barrier function by calcium/calmodulin-dependent protein kinase II

2001 • 70 citations

Mammal-specific, ERK-dependent, Caldesmon Phosphorylation in Smooth Muscle

1999 • 68 citations

Phosphorylation and activation of smooth muscle myosin light chain kinase by MAP kinase and cyclin-dependent kinase-1

1996 • 65 citations

Inhibition of p42 and p44 MAP kinase does not alter smooth muscle contraction in swine carotid artery

1998 • 59 citations

Phosphorylation of smooth muscle caldesmon by calmodulin-dependent protein kinase II. Identification of the phosphorylation sites.

1990 • 57 citations

Mutant Caldesmon Lacking cdc2 Phosphorylation Sites Delays M-Phase Entry and Inhibits Cytokinesis

2001 • 50 citations

Characterization of mitotically phosphorylated caldesmon.

1992 • 48 citations

Essential role of caldesmon in the actin filament reorganization induced by glucocorticoids.

1995 • 45 citations

Stretch-dependent activation and desensitization of mitogen-activated protein kinase in carotid arteries

1997 • 45 citations

Thrombin-induced alterations in lung fluid balance in awake sheep

1985 • 43 citations

Identification of functioning regulatory sites and a new myosin binding site in the C-terminal 288 amino acids of caldesmon expressed from a human clone

1993 • 29 citations

The Major Myosin-binding Site of Caldesmon Resides Near Its N-terminal Extreme

2000 • 29 citations

Reversal of caldesmon binding to myosin with calcium-calmodulin or by phosphorylating caldesmon

1993 • 27 citations

Microinjection of nonmuscle and smooth muscle caldesmon into fibroblasts and muscle cells.

1990 • 27 citations

Caldesmon

1996 • 26 citations

Casein Kinase II Phosphorylation of Caldesmon Downregulates Myosin−Caldesmon Interactions

2000 • 17 citations

Actomyosin cross‐linking by caldesmon in non‐muscle cells

2001 • 15 citations