Emerging roles for p120-catenin in cell adhesion and cancer

Convergence of Wnt, ß-Catenin, and Cadherin Pathways

2004 • 2,451 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

2002 • 817 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

A core function for p120-catenin in cadherin turnover

2003 • 714 citations

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

1995 • 672 citations

Cadherins as Modulators of Cellular Phenotype

2003 • 656 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn

1998 • 566 citations

P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases

2000 • 563 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Recycling of E-Cadherin

1999 • 538 citations

A novel role for p120 catenin in E-cadherin function

2002 • 514 citations

The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor

2001 • 499 citations

Rho Guanine Dissociation Inhibitors

1999 • 487 citations

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.

1990 • 480 citations

Inhibition of RhoA by p120 catenin

2000 • 459 citations

Selective Uncoupling of P120ctn from E-Cadherin Disrupts Strong Adhesion

2000 • 456 citations

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

1991 • 435 citations

The p120 catenin family: Complex roles in adhesion, signaling and cancer

2000 • 427 citations

Cadherin Engagement Regulates Rho family GTPases

2001 • 421 citations

Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells

2003 • 399 citations

The Catenin p120^ctn Interacts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor

1999 • 396 citations

N-CoR Mediates DNA Methylation-Dependent Repression through a Methyl CpG Binding Protein Kaiso

2003 • 395 citations

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1992 • 394 citations

The ins and outs of E-cadherin trafficking

2004 • 356 citations

p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction

2003 • 329 citations

The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation

2004 • 312 citations

Effects of Regulated Expression of Mutant RhoA and Rac1 Small GTPases on the Development of Epithelial (MDCK) Cell Polarity

1998 • 297 citations

Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.

1995 • 290 citations

The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides

2002 • 277 citations

p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion

2001 • 272 citations

Regulation of Rho GTPases by p120-catenin

2001 • 265 citations

Tyrosine Phosphorylation and Src Family Kinases Control Keratinocyte Cell–Cell Adhesion

1998 • 254 citations

p120 catenin associates with kinesin and facilitates the transport of cadherin–catenin complexes to intercellular junctions

2003 • 251 citations

p120ctn Acts as an Inhibitory Regulator of Cadherin Function in Colon Carcinoma Cells

1999 • 229 citations

The Rho Small G Protein Family-Rho GDI System as a Temporal and Spatial Determinant for Cytoskeletal Control

1998 • 200 citations

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

2001 • 185 citations

Rho1 interacts with p120ctn and α-catenin, and regulates cadherin-based adherens junction components inDrosophila

2002 • 179 citations

Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes

1996 • 165 citations

The Cytoplasmic Tyrosine Kinase FER Is Associated with the Catenin-Like Substrate pp120 and Is Activated by Growth Factors

1995 • 163 citations

Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell–cell adhesion

2002 • 162 citations

Altered expression of the catenin p120 in human cancer: implications for tumor progression

2002 • 157 citations

p120, a p120-related protein (p100), and the cadherin/catenin complex.

1995 • 156 citations

Mechanisms of VE-cadherin Processing and Degradation in Microvascular Endothelial Cells

2003 • 154 citations

The Novel Catenin p120casBinds Classical Cadherins and Induces an Unusual Morphological Phenotype in NIH3T3 Fibroblasts

1996 • 153 citations

Nuclear localization of the p120 ^ctn Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression

1999 • 153 citations

Identification of Src Phosphorylation Sites in the Catenin p120

2001 • 142 citations

The Morphogenetic Role of Cadherin Cell Adhesion Molecules in Human Cancer: A Thematic Review

1998 • 141 citations

Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells.

1991 • 137 citations

The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin–catenin function during epidermal morphogenesis

2003 • 131 citations

Expression of catenins and E-cadherin during epithelial restitution in inflammatory bowel disease

1998 • 130 citations

Continuous association of cadherin with β-catenin requires the non-receptor tyrosine-kinase Fer

2004 • 126 citations

Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate.

1993 • 125 citations

A Novel Interaction between Kinesin and p120 Modulates p120 Localization and Function

2004 • 125 citations

Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component

2003 • 123 citations

Receptor Protein-tyrosine Phosphatase RPTPμ Binds to and Dephosphorylates the Catenin p120

2000 • 122 citations

Protein kinase C regulates endocytosis and recycling of E-cadherin

2002 • 116 citations

Regulation of Cell–Cell Adhesion of MDCK Cells by Cdc42 and Rac1 Small GTPases

1997 • 106 citations

Identification of a New Catenin: the Tyrosine Kinase Substrate p120^cas Associates with E-Cadherin Complexes

1994 • 102 citations

Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac

2004 • 102 citations

EGFR signaling to p120-catenin through phosphorylation at Y228

2004 • 99 citations

Transformation-Specific Tyrosine Phosphorylation of a Novel Cellular Protein in Chicken Cells Expressing Oncogenic Variants of the Avian Cellular src Gene

1989 • 95 citations

The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120ctn

2002 • 92 citations

Mechanism of extracellular domain-deleted dominant negative cadherins

1999 • 90 citations

Protein kinase C modifications of VE-cadherin, p120, and β-catenin contribute to endothelial barrier dysregulation induced by thrombin

2003 • 88 citations

Binding site for p120/δ-catenin is not required for Drosophila E-cadherin function in vivo

2003 • 84 citations

p120 Catenin Is Required for Growth Factor–dependent Cell Motility and Scattering in Epithelial Cells

2003 • 79 citations

Regulation of p120-catenin nucleocytoplasmic shuttling activity

2003 • 78 citations

Co-downregulation of cell adhesion proteins α- and β-catenins, p120CTN, E-cadherin, and CD44 in prostatic adenocarcinomas

2001 • 76 citations

Adhesion-Associated and PKC-Modulated Changes in Serine/Threonine Phosphorylation of p120-Catenin

2003 • 71 citations

Dephosphorylation of the catenins p120 and p100 in endothelial cells in response to inflammatory stimuli

1999 • 68 citations

Cadherin function in junctional complex rearrangement and posttranslational control of cadherin expression

1999 • 67 citations

The Protein-tyrosine Phosphatase SHP-1 Binds to and Dephosphorylates p120 Catenin

2000 • 63 citations

Contextual Binding of p120 to E-cadherin at the Basolateral Plasma Membrane in Polarized Epithelia

2003 • 60 citations

Dephosphorylation of the Cadherin-associated p100/p120 Proteins in Response to Activation of Protein Kinase C in Epithelial Cells

1997 • 54 citations

Vascular endothelial growth factor stimulates dephosphorylation of the catenins p120 and p100 in endothelial cells

2000 • 44 citations