Multiple roles for Cdc42 in cell regulation

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

A homochiral metal–organic porous material for enantioselective separation and catalysis

2000 • 3,832 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

1998 • 933 citations

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

2000 • 913 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

Identification of genes required for cytoplasmic localization in early C. elegans embryos

1988 • 841 citations

Ras and Rho GTPases

2000 • 779 citations

A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

2000 • 740 citations

Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein

2000 • 739 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

Mechanism of N-Wasp Activation by Cdc42 and Phosphatidylinositol 4,5-Bisphosphate

2000 • 615 citations

CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae.

1990 • 605 citations

Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity

1999 • 546 citations

Integration of Multiple Signals Through Cooperative Regulation of the N-WASP-Arp2/3 Complex

2000 • 512 citations

A nuclear cap binding protein complex involved in pre-mRNA splicing

1994 • 506 citations

Developmental Control of Endocytosis in Dendritic Cells by Cdc42

2000 • 440 citations

Signaling to Rho GTPases

1999 • 411 citations

The Ras branch of small Gtpases: Ras family members don’t fall far from the tree

2000 • 408 citations

Regulators and effectors of the ARF GTPases

2000 • 396 citations

Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells

1999 • 340 citations

Effectors for the Rho GTPases

1999 • 327 citations

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1993 • 319 citations

Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish

2000 • 301 citations

The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1

1996 • 293 citations

A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation

2000 • 276 citations

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3

1996 • 271 citations

Signaling to Actin Dynamics

1999 • 260 citations

Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity.

1993 • 256 citations

Development of cell polarity in budding yeast

1991 • 252 citations

Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg Extracts

1998 • 219 citations

A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding.

1996 • 215 citations

A novel Cdc42Hs mutant induces cellular transformation

1997 • 213 citations

The γ-subunit of the coatomer complex binds Cdc42 to mediate transformation

2000 • 211 citations

Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.

1990 • 204 citations

Mammalian Cdc42 Is a Brefeldin A-sensitive Component of the Golgi Apparatus

1996 • 200 citations

CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.

1995 • 190 citations

The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42

1998 • 188 citations

EARLY PATTERNING OF THE C. ELEGANS EMBRYO

1998 • 173 citations

The Ran decathlon: multiple roles of Ran

2000 • 162 citations

Regulation of cortical actin cytoskeleton assembly during polarized cell growth in budding yeast.

1995 • 158 citations

The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1

2000 • 145 citations

Cloning and Characterization of a Novel Cdc42-associated Tyrosine Kinase, ACK-2, from Bovine Brain

1997 • 104 citations

Multiple aspects of Rab protein action in the secretory pathway: Focus on Rab3 and Rab6

2000 • 93 citations

Cdc42 Stimulates RNA Splicing via the S6 Kinase and a Novel S6 Kinase Target, the Nuclear Cap-binding Complex

2000 • 82 citations

Activation of the Cdc42-associated Tyrosine Kinase-2 (ACK-2) by Cell Adhesion via Integrin β1

1999 • 80 citations

PDZ Domains and the Formation of Protein Networks at the Plasma Membrane

1998 • 78 citations

The identification and characterization of an epidermal growth factor-stimulated phosphorylation of a specific low molecular weight GTP-binding protein in a reconstituted phospholipid vesicle system.

1990 • 60 citations

The Nuclear Cap-binding Complex Is a Novel Target of Growth Factor Receptor-coupled Signal Transduction

1999 • 42 citations