Pulmonary Endothelial Cell Barrier Enhancement by Sphingosine 1-Phosphate

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

Cytoskeletal regulation of pulmonary vascular permeability

2001 • 954 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation

2001 • 585 citations

Activation of Arp2/3 complex-mediated actin polymerization by cortactin

2001 • 561 citations

Dedicated Myosin Light Chain Kinases with Diverse Cellular Functions

2001 • 553 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation.

1995 • 451 citations

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

1991 • 435 citations

Cortactin: coupling membrane dynamics to cortical actin assembly

2001 • 413 citations

Regulated Interactions between Dynamin and the Actin-Binding Protein Cortactin Modulate Cell Shape

2000 • 391 citations

A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease

2002 • 367 citations

Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCgamma, Crk, and Grb2.

1996 • 343 citations

Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis

2000 • 276 citations

The Role of Tyrosine Phosphorylation of Cortactin in the Locomotion of Endothelial Cells

1998 • 271 citations

Identification of a Novel Cortactin SH3 Domain-Binding Protein and Its Localization to Growth Cones of Cultured Neurons

1998 • 257 citations

Down-regulation of the Filamentous Actin Cross-linking Activity of Cortactin by Src-mediated Tyrosine Phosphorylation

1997 • 247 citations

Stress fiber organization regulated by MLCK and Rho-kinase in cultured human fibroblasts

2001 • 236 citations

Shear Stress-Mediated Cytoskeletal Remodeling and Cortactin Translocation in Pulmonary Endothelial Cells

2002 • 212 citations

Myosin light chain kinase in endothelium: molecular cloning and regulation.

1997 • 200 citations

Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1

1998 • 197 citations

Cortactin Tyrosine Phosphorylation Requires Rac1 Activity and Association with the Cortical Actin Cytoskeleton

2003 • 183 citations

Cortactin Interacts with WIP in Regulating Arp2/3 Activation and Membrane Protrusion

2003 • 174 citations

Osmotic stress-induced remodeling of the cortical cytoskeleton

2002 • 162 citations

Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase‐3β

2002 • 159 citations

Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin

2002 • 156 citations

Differential Regulation of Alternatively Spliced Endothelial Cell Myosin Light Chain Kinase Isoforms by p60Src

2001 • 150 citations

Cytoskeletal Activation and Altered Gene Expression in Endothelial Barrier Regulation by Simvastatin

2003 • 149 citations

Cortactin Associates with the Cell-Cell Junction Protein ZO-1 in both Drosophila and Mouse

1998 • 141 citations

Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells

2002 • 140 citations

A Single Human Myosin Light Chain Kinase Gene (MLCK; MYLK)Transcribes Multiple Nonmuscle Isoforms

1999 • 134 citations

A fluorescent resonant energy transfer–based biosensor reveals transient and regional myosin light chain kinase activation in lamella and cleavage furrows

2002 • 119 citations

EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer

1997 • 99 citations

Novel interaction of cortactin with endothelial cell myosin light chain kinase

2002 • 99 citations

Caspase‐dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF‐α‐mediated bovine pulmonary endothelial cell apoptosis

2003 • 96 citations

Cell Volume-dependent Phosphorylation of Proteins of the Cortical Cytoskeleton and Cell-Cell Contact Sites

2000 • 95 citations

Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury

2000 • 92 citations

Src is required for cell migration and shape changes induced by fibroblast growth factor 1

1999 • 84 citations

Single‐cell epithelial defects close rapidly by an actinomyosin purse string mechanism with functional tight junctions

2002 • 79 citations

Thrombin-mediated Focal Adhesion Plaque Reorganization in Endothelium: Role of Protein Phosphorylation

1997 • 76 citations

Diperoxovanadate alters endothelial cell focal contacts and barrier function: role of tyrosine phosphorylation

2000 • 76 citations

Tyrosine Phosphorylation of Cortactin Is Required for H2O2-mediated Injury of Human Endothelial Cells

2000 • 60 citations

Functional Interactions between the p35 Subunit of the Arp2/3 Complex and Calmodulin in Yeast

2000 • 44 citations

Hepatocyte Growth Factor/Scatter Factor-induces phosphorylation of cortactin in A431 cells in a Src kinase-independent manner

2001 • 41 citations

Transient suppression of cortactin ectopically induces large telencephalic neurons towards a GABAergic phenotype

2000 • 27 citations