Soluble Ligands of the αvβ4 Integrin Mediate Enhanced Tyrosine Phosphorylation of Multiple Proteins in Adherent Bovine Pulmonary Artery Endothelial Cells

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Integrins and other cell adhesion molecules

1990 • 1,990 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Fundamental Immunology

1994 • 903 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

1991 • 713 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

Novel purification of vitronectin from human plasma by heparin affinity chromatography.

1988 • 525 citations

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex.

1993 • 510 citations

Structure and Biological Role of Vitronectin

1991 • 477 citations

Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling

1993 • 447 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family.

1994 • 395 citations

Involvement of integrin alpha V gene expression in human melanoma tumorigenicity.

1992 • 380 citations

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.

1991 • 368 citations

Association of insulin receptor substrate-1 with integrins

1994 • 362 citations

Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectin.

1993 • 358 citations

The role of integrins in the maintenance of endothelial monolayer integrity.

1991 • 290 citations

Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.

1994 • 276 citations

Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.

1994 • 264 citations

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

1993 • 257 citations

Molecular sieving characteristics of the cultured endothelial monolayer

1987 • 254 citations

Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin

1993 • 253 citations

The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.

1990 • 251 citations

Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.

1994 • 244 citations

Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells.

1994 • 241 citations

Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin.

1990 • 238 citations

Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells

1993 • 222 citations

Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.

1993 • 219 citations

Specific binding of the human S protein (vitronectin) to streptococci, Staphylococcus aureus, and Escherichia coli

1987 • 216 citations

Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.

1994 • 214 citations

Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells.

1993 • 209 citations

Regulation of vascular integrins [published erratum appears in Blood 1994 Apr 1;83(7):2013]

1993 • 199 citations

Integrating with integrins.

1994 • 189 citations

The membrane attack mechanism of complement. Isolation and subunit composition of the C5b-9 complex.

1975 • 174 citations

Multimeric vitronectin. Identification and characterization of conformation-dependent self-association of the adhesive protein.

1993 • 155 citations

Protein tyrosine phosphorylation and the adhesive functions of platelets

1991 • 148 citations

Regulation of vascular integrins [published erratum appears in Blood 1994 Apr 1;83(7):2013]

1993 • 134 citations

Human endothelial cells express integrin receptors on the luminal aspect of their membrane

1992 • 131 citations

Isolation and Characterization of a Platelet Membrane Protein Related to the Vitronectin Receptor

1989 • 109 citations

Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion

1994 • 105 citations

Accentuated Formation of the Terminal C5b-9 Complement Complex in Patient Plasma Precedes Development of the Adult Respiratory Distress Syndrome

1988 • 95 citations

Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells.

1992 • 95 citations

The alpha v beta 5 integrin receptor regulates receptor-mediated endocytosis of vitronectin

1993 • 94 citations

Vitronectin-driven human keratinocyte locomotion is mediated by the alpha v beta 5 integrin receptor.

1994 • 86 citations

Soluble alpha v beta 3-integrin ligands raise [Ca2+]i in rat osteoclasts and mouse-derived osteoclast-like cells

1994 • 82 citations

Heparin-binding properties of vitronectin are linked to complex formation as illustrated by in vitro polymerization and binding to the terminal complement complex

1992 • 72 citations

Alteration of vitronectin. Characterization of changes induced by treatment with urea.

1993 • 70 citations

Clustering of vitronectin and RGD peptides on microspheres leads to engagement of integrins on the luminal aspect of endothelial cell membrane

1994 • 62 citations

The complement SC5b-9 complex mediates cell adhesion through a vitronectin receptor.

1990 • 59 citations

SC5b‐7, SC5b‐8 and SC5b‐9 complexes of complement: ultrastructure and localization of the S‐protein (vitronectin) within the macromolecules

1989 • 52 citations

Soluble complex of complement increases hydraulic conductivity in single microvessels of rat lung.

1993 • 37 citations

Binding and processing of multimeric vitronectin by vascular endothelial cells.

1993 • 34 citations

Functions and relevance of the terminal complement sequence

1990 • 34 citations

An enzyme-linked immunoabsorbent assay for the quantitation of the terminal complement complex from cell membranes or in activated human sera

1986 • 25 citations