Regulation of cortical structure by the ezrin-radixin-moesin protein family

Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association

1998 • 849 citations

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.

1994 • 790 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

1996 • 601 citations

Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2

1998 • 592 citations

Identification of EBP50: A PDZ-containing Phosphoprotein that Associates with Members of the Ezrin-Radixin-Moesin Family

1997 • 582 citations

The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

1998 • 582 citations

An Apical PDZ Protein Anchors the Cystic Fibrosis Transmembrane Conductance Regulator to the Cytoskeleton

1998 • 472 citations

Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells

1993 • 426 citations

cAMP-mediated inhibition of the epithelial brush border Na ⁺ /H ⁺ exchanger, NHE3, requires an associated regulatory protein

1997 • 426 citations

Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein

1997 • 424 citations

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site.

1995 • 422 citations

A C-terminal motif found in the β ₂ -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na ⁺ /H ⁺ exchanger regulatory factor family of PDZ proteins

1998 • 406 citations

Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family.

1994 • 395 citations

F-actin binding site masked by the intramolecular association of vinculin head and tail domains

1995 • 371 citations

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction

1997 • 363 citations

Ezrin: A protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures

1997 • 350 citations

Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members.

1994 • 347 citations

Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger.

1995 • 344 citations

Association of Ezrin with Intercellular Adhesion Molecule-1 and -2 (ICAM-1 and ICAM-2)

1998 • 325 citations

Ezrin Is an Effector of Hepatocyte Growth Factor–mediated Migration and Morphogenesis in Epithelial Cells

1997 • 317 citations

Ezrin is a cyclic AMP-dependent protein kinase anchoring protein

1997 • 309 citations

Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins

1997 • 303 citations

Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells.

1983 • 294 citations

Peptide binding consensus of the NHE‐RF‐PDZ1 domain matches the C‐terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)

1998 • 278 citations

NHE3 Kinase A Regulatory Protein E3KARP Binds the Epithelial Brush Border Na+/H+ Exchanger NHE3 and the Cytoskeletal Protein Ezrin

1998 • 269 citations

Moesin: a member of the protein 4.1-talin-ezrin family of proteins.

1991 • 250 citations

Moesin Interacts with the Cytoplasmic Region of Intercellular Adhesion Molecule-3 and Is Redistributed to the Uropod of T Lymphocytes during Cell Polarization

1997 • 238 citations

ICAM-2 redistributed by ezrin as a target for killer cells

1996 • 233 citations

Protein Kinase C-θ Phosphorylation of Moesin in the Actin-binding Sequence

1998 • 213 citations

An intramolecular association between the head and tail domains of vinculin modulates talin binding.

1994 • 212 citations

A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization.

1989 • 211 citations

Association of the Myosin-binding Subunit of Myosin Phosphatase and Moesin: Dual Regulation of Moesin Phosphorylation by Rho-associated Kinase and Myosin Phosphatase

1998 • 210 citations

Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.

1995 • 208 citations

Essential functions of ezrin in maintenance of cell shape and lamellipodial extension in normal and transformed fibroblasts

1997 • 206 citations

Phosphorylation of Threonine 558 in the Carboxyl-terminal Actin-binding Domain of Moesin by Thrombin Activation of Human Platelets

1995 • 205 citations

The ezrin protein family: membrane-cytoskeleton interactions and disease associations

1997 • 205 citations

Identification of a phosphatidylinositol‐4,5‐bisphosphate‐binding domain in the N‐terminal region of ezrin

1995 • 198 citations

The Carboxyl-terminal Region of EBP50 Binds to a Site in the Amino-terminal Domain of Ezrin That Is Masked in the Dormant Molecule

1998 • 194 citations

Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin.

1992 • 189 citations

Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44

1998 • 188 citations

RhoA-Dependent Phosphorylation and Relocalization of ERM Proteins into Apical Membrane/Actin Protrusions in Fibroblasts

1998 • 183 citations

Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes.

1995 • 169 citations

ERM (Ezrin/Radixin/Moesin)-based Molecular Mechanism of Microvillar Breakdown at an Early Stage of Apoptosis

1997 • 164 citations

C-Terminal Threonine Phosphorylation Activates ERM Proteins to Link the Cell's Cortical Lipid Bilayer to the Cytoskeleton

1998 • 147 citations

Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domain.

1995 • 135 citations

Biochemical Characterization of Ezrin-Actin Interaction

1996 • 125 citations

Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl

1998 • 120 citations

Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain

1999 • 119 citations

A Dual Involvement of the Amino-terminal Domain of Ezrin in F- and G-actin Binding

1997 • 112 citations

Molecular dissection of radixin: distinct and interdependent functions of the amino- and carboxy-terminal domains.

1995 • 106 citations

Ezrin-calpain I interactions in gastric parietal cells

1993 • 96 citations

A human and a plant intron-containing tRNATyr gene are both transcribed in a HeLa cell extract but spliced along different pathways.

1987 • 88 citations

Three determinants in ezrin are responsible for cell extension activity.

1997 • 63 citations

Unopposed phosphatase action initiates ezrin dysfunction: a potential mechanism for anoxic injury

1997 • 31 citations

Regulation Mechanism of ERM Protein/Plasma Membrane Association : Possible Involvement of Phosphatidylinositol Turnover and Rho-dependent Signaling Pathway

1996 • 13 citations

Mapping of Ezrin Dimerization Using Yeast Two-Hybrid Screening

1998 • 11 citations