Interaction of Focal Adhesion Kinase with Cytoskeletal Protein Talin

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

1990 • 851 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

1991 • 713 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.

1991 • 578 citations

The cell substrate attachment (CSAT) antigen has properties of a receptor for laminin and fibronectin.

1985 • 503 citations

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.

1990 • 480 citations

Focal adhesion kinase (p125FAK): A point of convergence in the action of neuropeptides, integrins, and oncogenes

1992 • 453 citations

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.

1993 • 408 citations

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.

1994 • 331 citations

Sequence and domain structure of talin

1990 • 314 citations

Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak- binding region

1994 • 311 citations

Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.

1994 • 305 citations

Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

1992 • 296 citations

Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton

1993 • 277 citations

Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts.

1989 • 256 citations

ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

1993 • 212 citations

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

1992 • 199 citations

Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells.

1991 • 195 citations

Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras.

1994 • 184 citations

Focal adhesion kinase: an integrin-linked protein tyrosine kinase

1993 • 177 citations

Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells.

1991 • 156 citations

Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis.

1990 • 141 citations

Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125^FAK and paxillin induced by bombesin and endothelin

1994 • 138 citations

Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants.

1995 • 136 citations

Angiotensin II stimulates protein-tyrosine phosphorylation in a calcium-dependent manner.

1990 • 118 citations

Bradykinin and bombesin rapidly stimulate tyrosine phosphorylation of a 120-kDa group of proteins in Swiss 3T3 cells.

1991 • 117 citations

Stimulation of tyrosine kinase activity in anti-phosphotyrosine immune complexes of Swiss 3T3 cell lysates occurs rapidly after addition of bombesin, vasopressin, and endothelin to intact cells.

1991 • 84 citations

Mitogenic Action of Lysophosphatidic Acid

1991 • 50 citations