Regulation of Cadherin Function by Rho and Rac: Modulation by Junction Maturation and Cellular Context

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Morphogenetic roles of classic cadherins

1995 • 1,468 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1993 • 997 citations

The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.

1988 • 810 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

Structural basis of calcium-induced E-cadherin rigidification and dimerization

1996 • 688 citations

Signal transduction through beta-catenin and specification of cell fate during embryogenesis.

1996 • 663 citations

A novel endothelial-specific membrane protein is a marker of cell-cell contacts.

1992 • 637 citations

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.

1994 • 633 citations

The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin).

1995 • 573 citations

The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn

1998 • 566 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones.

1996 • 500 citations

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

1997 • 448 citations

Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin.

1989 • 436 citations

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

1995 • 410 citations

The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-alpha catenin fusion molecules.

1994 • 398 citations

Regulation of TNF-α-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells

1998 • 390 citations

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

1997 • 378 citations

Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function

1997 • 357 citations

A role for cadherins in tissue formation

1996 • 355 citations

Identification of IQGAP as a Putative Target for the Small GTPases, Cdc42 and Rac1

1996 • 315 citations

Lateral dimerization is required for the homophilic binding activity of C-cadherin.

1996 • 307 citations

Rho: theme and variations

1996 • 290 citations

Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.

1992 • 280 citations

Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth.

1990 • 273 citations

Rho: a connection between membrane receptor signalling and the cytoskeleton

1996 • 271 citations

Soluble 80‐kd fragment of cell‐CAM 120/80 disrupts cell‐cell adhesion

1987 • 239 citations

Biosynthesis of the cell adhesion molecule uvomorulin (E-cadherin) in Madin-Darby canine kidney epithelial cells.

1991 • 226 citations

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation

1994 • 223 citations

Catenin-dependent and -independent Functions of Vascular Endothelial Cadherin

1995 • 220 citations

Expression and role of E- and P-cadherin adhesion molecules in embryonic histogenesis II. Skin morphogenesis

1989 • 201 citations

CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.

1995 • 190 citations

Cell Growth and Division

1967 • 187 citations

Protein tyrosine phosphatases as adhesion receptors

1995 • 182 citations

The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export

1997 • 171 citations

A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila

1995 • 169 citations

Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells

1997 • 161 citations

Glycosyl phosphatidylinositol--anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion.

1992 • 158 citations

Distinguishing roles of the membrane-cytoskeleton and cadherin mediated cell-cell adhesion in generating different Na+,K(+)-ATPase distributions in polarized epithelia.

1993 • 155 citations

Regulation of human B-cell precursor adhesion to bone marrow stromal cells by cytokines that exert opposing effects on the expression of vascular cell adhesion molecule-1 (VCAM-1)

1993 • 155 citations

Spatial and temporal dissection of immediate and early events following cadherin-mediated epithelial cell adhesion.

1993 • 153 citations

P- and E-Cadherin Are in Separate Complexes in Cells Expressing Both Cadherins

1993 • 146 citations

Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules.

1995 • 135 citations

Distinct cadherin—catenin complexes in Ca²⁺ dependent cell—cell adhesion

1994 • 120 citations

Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues.

1989 • 120 citations

Antidesmosomal monoclonal antibody in the diagnosis of intracranial tumours

1987 • 119 citations

A novel role for RhoGDI as an inhibitor of GAP proteins.

1993 • 117 citations

Expression and role of E- and P-cadherin adhesion molecules in embryonic histogenesis: I. Lung epithelial morphogenesis

1989 • 101 citations

N-cadherin in adult rat cardiomyocytes in culture II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes

1996 • 93 citations

Immunoelectron characterisation of the inter-endothelial junctions of human term placenta

1993 • 87 citations

LI-Cadherin–mediated Cell–Cell Adhesion Does Not Require Cytoplasmic Interactions

1997 • 87 citations

Cadherin-mediated cell interactions are necessary for the activation of MyoD in Xenopus mesoderm.

1994 • 81 citations

Calcium-Induced Changes in Distribution and Solubility of Cadherins, Integrins and Their Associated Cytoplasmic Proteins in Human Keratinocytes

1995 • 64 citations

Rubidium transport and ouabain binding in normal and virally transformed mouse fibroblasts

1976 • 42 citations

Calcium-Induced Intercellular Adhesion of Keratinocytes Does not Involve Accumulation of β₁Integrins at Cell-Cell Contacts and Does not Involve Changes in the Levels or Phosphorylation of Catenins

1998 • 17 citations