Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

An electrophoretic study of the low-molecular-weight components of myosin

1970 • 706 citations

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1997 • 687 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes

1997 • 560 citations

Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study

1992 • 456 citations

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation.

1995 • 451 citations

Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3‘: 5‘-monophosphate-dependent protein kinase.

1978 • 386 citations

p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts

1999 • 380 citations

Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase.

1985 • 340 citations

A Conserved Negative Regulatory Region in αPAK: Inhibition of PAK Kinases Reveals Their Morphological Roles Downstream of Cdc42 and Rac1

1998 • 325 citations

A Role for P21-Activated Kinase in Endothelial Cell Migration

1999 • 295 citations

Emerging from the Pak: the p21-activated protein kinase family

1997 • 285 citations

Actions of Rho Family Small G Proteins and p21-Activated Protein Kinases on Mitogen-Activated Protein Kinase Family Members

1996 • 275 citations

Involvement of myosin light-chain kinase in endothelial cell retraction.

1990 • 249 citations

Myosin light chain kinases.

1997 • 247 citations

Identification, phosphorylation, and dephosphorylation of a second site for myosin light chain kinase on the 20,000-dalton light chain of smooth muscle myosin.

1986 • 246 citations

PAK promotes morphological changes by acting upstream of Rac

1998 • 211 citations

Regulatory and structural motifs of chicken gizzard myosin light chain kinase.

1990 • 208 citations

Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK).

1998 • 199 citations

The p21Rac/Cdc42-activated kinases (PAKs)

1998 • 190 citations

Correlation of myosin light chain phosphorylation with isometric contraction of fibroblasts.

1993 • 186 citations

Phosphorylation of mammalian myosin light chain kinases by the catalytic subunit of cyclic AMP-dependent protein kinase and by cyclic GMP-dependent protein kinase.

1984 • 176 citations

Antigen-induced Secretion of Histamine and the Phosphorylation of Myosin by Protein Kinase C in Rat Basophilic Leukemia Cells

1989 • 161 citations

TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways.

1997 • 150 citations

Regulation of permeabilized endothelial cell retraction by myosin phosphorylation

1991 • 149 citations

Molecular characterization of a mammalian smooth muscle myosin light chain kinase.

1991 • 148 citations

Different Molecular Mechanisms for Rho Family GTPase-dependent, Ca2+-independent Contraction of Smooth Muscle

1998 • 143 citations

Identification and Molecular Cloning of a p21cdc42/rac1-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets

1995 • 132 citations

Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II

2000 • 132 citations

Phosphorylation of smooth muscle myosin light chain kinase by Ca2+-activated, phospholipid-dependent protein kinase.

1985 • 128 citations

Insulin Activates a p21-activated Kinase in Muscle Cells via Phosphatidylinositol 3-Kinase

1996 • 127 citations

The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells.

1993 • 122 citations

Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation.

1990 • 121 citations

p21-activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells.

1998 • 90 citations

Phosphorylation of Caldesmon by p21-activated Kinase

2000 • 86 citations

Activation of p21-CDC42/Rac-Activated Kinases by CD28 Signaling: p21-Activated Kinase (PAK) and MEK Kinase 1 (MEKK1) May Mediate the Interplay Between CD3 and CD28 Signals

1998 • 80 citations

Cutting Edge: p21-Activated Kinase (PAK) Is Required for Fas-Induced JNK Activation in Jurkat Cells

1998 • 78 citations

Phosphorylation of smooth muscle myosin light chain kinase by Ca2+/calmodulin-dependent protein kinase II: Comparative study of the phosphorylation sites

1990 • 76 citations

Phosphorylation of two sites on smooth muscle myosin. Effects on contraction of glycerinated vascular smooth muscle.

1988 • 40 citations

Purification and characterization of platelet myosin

1992 • 40 citations

PMA and calcium ionophore induce myosin and F‐actin rearrangement during histamine secretion from RBL‐2H3 cells

1994 • 34 citations

Primary Substrate Specificity Determinants for the H4‐Specific Protease‐Activated Protein Phosphotransferase

1983 • 24 citations

Localization of an actin binding domain in smooth muscle myosin light chain kinase.

1997 • 22 citations

Diphosphorylation of platelet myosin ex vivo in the initial phase of activation by thrombin

1992 • 22 citations

Multisite phosphorylation of a synthetic peptide derived from the carboxyl terminus of the ribosomal protein S6.

1991 • 17 citations

Synthetic peptides derived from the nonmuscle myosin light chains are highly specific substrates for protein kinase C

1988 • 15 citations

Nonmuscle myosin phosphorylation sites for calcium-dependent and calcium-independent protein kinases

1986 • 13 citations

Activation of an S6 kinase from human placenta by autophosphorylation.

1993 • 12 citations

Regulation of the Contractile Cycle in Smooth Muscle

1995 • 11 citations