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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Angiogenesis in health and disease

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2000 • 4,120 citations

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1993 • 3,605 citations

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1994 • 3,367 citations

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1996 • 2,844 citations

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VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

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2001 • 1,874 citations

Role of integrins in cell invasion and migration

2002 • 1,719 citations

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2001 • 1,707 citations

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2003 • 1,691 citations

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2001 • 1,640 citations

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Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

1997 • 1,590 citations

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1997 • 1,590 citations

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1998 • 1,567 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy

2002 • 1,549 citations

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VEGF and the quest for tumour angiogenesis factors

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1993 • 1,391 citations

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Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

1999 • 1,291 citations

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

1995 • 1,280 citations

Angiopoietin-1 protects the adult vasculature against plasma leakage

2000 • 1,271 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

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1998 • 1,239 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,236 citations

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

2001 • 1,217 citations

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2003 • 1,216 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

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1994 • 1,104 citations

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Barriers to Drug Delivery in Solid Tumors

1994 • 1,064 citations

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

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1999 • 1,044 citations

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Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

1991 • 999 citations

Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1

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Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

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1998 • 887 citations

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Increased Vascularization in Mice Overexpressing Angiopoietin-1

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Delivery of molecular and cellular medicine to solid tumors

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2000 • 750 citations

Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

2002 • 726 citations

Molecular mechanisms of lymphangiogenesis in health and disease

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VEGF Gene Delivery to Myocardium

2000 • 692 citations

Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells

2001 • 692 citations

Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

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Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

1998 • 683 citations

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

1999 • 681 citations

Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.

2000 • 676 citations

Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.

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Vascular endothelial–cadherin is an important determinant of microvascular integrityinvivo

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Angiogenesis-Independent Endothelial Protection of Liver: Role of VEGFR-1

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2001 • 648 citations

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Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

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A structural superfamily of growth factors containing a cystine knot motif

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Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans

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Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice.

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A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.

1995 • 480 citations

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Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

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Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy

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Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure

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Lymphangiogenesis and tumor metastasis: myth or reality?

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Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF‐induced angiogenesis

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Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF)

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1996 • 321 citations

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VEGF: A modifier of the del22q11 (DiGeorge) syndrome?

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Vascular Permeability Factor (VPF)/Vascular Endothelial Growth Factor (VEGF) Receptor-1 Down-modulates VPF/VEGF Receptor-2-mediated Endothelial Cell Proliferation, but Not Migration, through Phosphatidylinositol 3-Kinase-dependent Pathways

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Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor.

1996 • 298 citations

Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells

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Overexpression of Thrombospondin-1 Decreases Angiogenesis and Inhibits the Growth of Human Cutaneous Squamous Cell Carcinomas

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Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic.

1997 • 277 citations

The pro‐ or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent

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Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias

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Delivery of molecular and cellular medicine to solid tumors

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Impaired angiogenesis in the aging kidney: Vascular endothelial growth factor and Thrombospondin-1 in renal disease

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Tumor angiogenesis and accessibility: Role of vascular endothelial growth factor

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Direct Cell Adhesion to the Angiopoietins Mediated by Integrins

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VEGF mediates angioblast migration during development of the dorsal aorta in Xenopus

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Distinct Requirements for Zebrafish Angiogenesis Revealed by aVEGF-AMorphant

2000 • 256 citations

MT1‐MMP expression promotes tumor growth and angiogenesis through an up‐regulation of vascular endothelial growth factor expression

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Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis

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Angiostatin gene transfer: Inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest

1998 • 239 citations

Tumor angiogenesis and accessibility: Role of vascular endothelial growth factor

2002 • 239 citations

Receptor Chimeras Indicate That the Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Modulates Mitogenic Activity of VEGFR-2 in Endothelial Cells

2000 • 236 citations

Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases

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The role of vascular endothelial growth factor (VEGF) in vasculogenesis, angiogenesis, and hematopoiesis in zebrafish development

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Expression of vascular endothelial growth factor receptors in smooth muscle cells

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The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer.

2001 • 210 citations

Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration

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Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability

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Structure, Expression and Receptor-Binding Properties of Placenta Growth Factor (PlGF)

1999 • 199 citations

Vascular Progenitors From Biology to Treatment

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Extracellular Proteolysis and Angiogenesis

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Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state

2000 • 193 citations

A monoclonal antibody to vascular endothelial–cadherin inhibits tumor angiogenesis without side effects on endothelial permeability

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Angiopoietin‐2 plays an important role in retinal angiogenesis

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A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration

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Analysis of Mural Cell Recruitment to Tumor Vessels

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Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1.

2001 • 180 citations

The Growth of Malignant Disease in Man and the Lower Animals, with special reference to the Vascular System.

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A critical role of placental growth factor in the induction of inflammation and edema formation

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Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I: An inventory in search of autocrine and paracrine loops

1998 • 175 citations

Analysis of the role of chemokines in angiogenesis

2003 • 175 citations

Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-γ and migration of endothelial cells expressing Flt 1

1998 • 172 citations

Human Melanoma Cells Secrete and Respond to Placenta Growth Factor and Vascular Endothelial Growth Factor

2000 • 171 citations

The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment

2003 • 169 citations

Kallistatin is a new inhibitor of angiogenesis and tumor growth

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VEGF Receptor Signaling and Endothelial Function

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Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases

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Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity

1999 • 156 citations

Vegf, vegf-B, vegf-C and their receptors KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa

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Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells

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Endothelial Progenitor Cells for Vascular Regeneration

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Heterogeneous Vascular Dependence of Tumor Cell Populations

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Matrix Metalloproteinase-9-Dependent Exposure of a Cryptic Migratory Control Site in Collagen is Required before Retinal Angiogenesis

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Lymphatic Vessels as Targets of Tumor Therapy?

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The Role of the Hemostatic System in Tumor Growth, Metastasis, and Angiogenesis: Tissue factor is a Bifunctional Molecule Capable of Inducing Both Fibrin Deposition and Angiogenesis in Cancer

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Tumor-associated macrophages: a molecular perspective

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Tissue Factor-Dependent Vascular Endothelial Growth Factor Production by Human Fibroblasts in Response to Activated Factor VII

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Choriocarcinoma: Transfilter Stimulation of Vasoproliferation in the Hamster Cheek Pouch—Studied by Light and Electron Microscopy<xref ref-type="fn" rid="FN2">2</xref>

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Properties of Two VEGF Receptors, Flt‐1 and KDR, in Signal Transduction^a

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KDR (VEGF Receptor 2) Is the Major Mediator for the Hypotensive Effect of VEGF

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Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells.

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Potential Role of the Angiopoietin/Tie2 System in Ischemia-Induced Retinal Neovascularization

2003 • 116 citations

Altered Extracellular Matrix Remodeling and Angiogenesis in Sponge Granulomas of Thrombospondin 2-Null Mice

2001 • 113 citations

KDR Stimulates Endothelial Cell Migration through Heterotrimeric G Protein Gq/11-mediated Activation of a Small GTPase RhoA

2002 • 112 citations

Loss of the VEGF164 and VEGF188 Isoforms Impairs Postnatal Glomerular Angiogenesis and Renal Arteriogenesis in Mice

2002 • 109 citations

Cell Type-Specific Expression of Neuropilins in an MCA-Occlusion Model in Mice Suggests a Potential Role in Post-Ischemic Brain Remodeling

2002 • 106 citations

Monoclonal antibodies to vascular endothelial growth factor (VEGF) and the VEGF receptor, FLT-1, inhibit the growth of C6 glioma in a mouse xenograft.

2001 • 105 citations

Angiozyme: A Novel angiogenesis inhibitor

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Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization

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Vessels of Death or Life

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Ischemia-Driven Angiogenesis

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Expanded Human Tissue Kallikrein Family – A Novel Panel of Cancer Biomarkers

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Angiopoietin 1 Promotes Tumor Angiogenesis and Tumor Vessel Plasticity of Human Cervical Cancer in Mice

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Platelets and Cancer: Implications for Antiangiogenic Therapy

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Expression and localization of placenta growth factor and PlGF receptors in human meningiomas

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Endogenous origin of the lymphatics in the avian chorioallantoic membrane

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Tissue factor and angiogenesis in cancer

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Phenotypic Overlap Between Hematopoietic Cells with Suggested Angioblastic Potential and Vascular Endothelial Cells

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THE GROWTH OF MALIGNANT DISEASE IN MAN AND THE LOWER ANIMALS,

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Expression and prognostic relevance of vascular endothelial growth factor (VEGF) and its receptor (FLT-1) in nephroblastoma

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Vascular Endothelial Growth Factor–Induced Genes in Human Umbilical Vein Endothelial Cells

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Tumor‐infiltrating endothelial cells and endothelial precursor cells in inflammatory breast cancer

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Vascular endothelial growth factor and its receptor correlate with angiogenesis and survival in pulmonary adenocarcinoma.

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Matrix metalloproteinases and angiogenesis

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The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia, and stroke: Insights from genetic studies

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Effect of hypoxia and endothelial loss on vascular smooth muscle cell responsiveness to VEGF-A: role of flt-1/VEGF-receptor-1

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Expression of vascular endothelial growth factor (VEGF) and VEGF receptor-1 (Flt-1) in Graves disease possibly correlated with increased vascular density

2001 • 59 citations

EXPRESSION OF THE VEGF-RECEPTOR Flt-1 IN BENIGN, PREMALIGNANT AND MALIGNANT PROSTATE TISSUES

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Angiogenic growth factors and their receptors in non-small cell lung carcinomas and their relationships to drug response in vitro.

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Complete inhibition of vascular endothelial growth factor (VEGF) activities with a bifunctional diabody directed against both VEGF kinase receptors, fms-like tyrosine kinase receptor and kinase insert domain-containing receptor.

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Thrombospondins as Anti-Angiogenic Therapeutic Agents

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KDR activation is crucial for VEGF₁₆₅-mediated Ca²⁺ mobilization in human umbilical vein endothelial cells

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Impaired angiogenesis in the aging kidney: Vascular endothelial growth factor and thrombospondin-1 in renal disease

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Role of Placenta Growth Factor in Cardiovascular Health

2002 • 29 citations

Angiogenic switch as a molecular target of malignant tumors.

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Vaccination against tumor neovascularization: Promise and reality

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Coagulation, Fibrinolysis and Angiogenesis: New Insights from Knockout Mice

2002 • 18 citations

Tales of the cryptic: unveiling more angiogenesis inhibitors

2002 • 16 citations

Vascular endothelial growth factor as a target opportunity in hematological malignancies

2002 • 13 citations