The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

1963 • 3,559 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

1996 • 1,589 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

1997 • 1,371 citations

Structure and Function of Intercellular Junctions

1974 • 1,339 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

1995 • 994 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1988 • 897 citations

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

1996 • 849 citations

Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments

1997 • 659 citations

Occludin is a functional component of the tight junction

1996 • 632 citations

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin

1998 • 592 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Heteromultimerization and NMDA Receptor-Clustering Activity of Chapsyn-110, a Member of the PSD-95 Family of Proteins

1996 • 539 citations

Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions

1998 • 532 citations

A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

1997 • 527 citations

Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation

1997 • 524 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

Structural basis for physiological regulation of paracellular pathways in intestinal epithelia

1987 • 514 citations

Cingulin, a new peripheral component of tight junctions

1988 • 505 citations

GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules

1997 • 503 citations

Direct Association of the Gap Junction Protein Connexin-43 with ZO-1 in Cardiac Myocytes

1998 • 492 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein

1994 • 452 citations

Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity.

1986 • 433 citations

Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein

1996 • 430 citations

Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

1995 • 418 citations

SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A.

1993 • 415 citations

Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cells

1995 • 393 citations

Assembly of the tight junction: the role of diacylglycerol.

1993 • 381 citations

Human CASK/LIN-2 Binds Syndecan-2 and Protein 4.1 and Localizes to the Basolateral Membrane of Epithelial Cells

1998 • 376 citations

Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.

1994 • 365 citations

Interaction of ion channels and receptors with PDZ domain proteins

1997 • 362 citations

SAPAPs

1997 • 356 citations

The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.

1996 • 353 citations

Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases

1998 • 349 citations

Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.

1995 • 337 citations

Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions.

1996 • 335 citations

PDZs and Receptor/Channel Clustering: Rounding Up the Latest Suspects

1996 • 322 citations

The Ras Target AF-6 Interacts with ZO-1 and Serves as a Peripheral Component of Tight Junctions in Epithelial Cells

1997 • 315 citations

Interactions between actin filaments and between actin filaments and membranes in quick-frozen and deeply etched hair cells of the chick ear.

1982 • 310 citations

COOH Terminus of Occludin Is Required for Tight Junction Barrier Function in Early Xenopus Embryos

1997 • 301 citations

Protein–protein interactions: PDZ domain networks

1996 • 292 citations

Symplekin, a novel type of tight junction plaque protein.

1996 • 286 citations

Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2.

1993 • 266 citations

Cell signalling: MAGUK magic

1996 • 248 citations

Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells

1994 • 232 citations

The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins.

1996 • 204 citations

Identification of the Protein 4.1 Binding Interface on Glycophorin C and p55, a Homologue of the Drosophila discs-large Tumor Suppressor Protein

1995 • 197 citations

Cytoplasmic regulation of tight-junction permeability: effect of plant cytokinins

1980 • 182 citations

Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila

1989 • 176 citations

Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells.

1988 • 165 citations

Detection of the tight junction-associated protein ZO-1 in astrocytes and other nonepithelial cell types

1992 • 162 citations

Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 α+ isoform

1997 • 160 citations

Ca++-calmodulin-dependent phosphorylation of myosin, and its role in brush border contraction in vitro.

1982 • 157 citations

Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif.

1991 • 148 citations

Involvement of a Heterotrimeric G Protein α Subunit in Tight Junction Biogenesis

1996 • 136 citations

Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability

1996 • 134 citations

ZO-1 mRNA and protein expression during tight junction assembly in Caco-2 cells.

1989 • 129 citations

Human Homologue of the Drosophila Discs Large Tumor Suppressor Binds to p56 Tyrosine Kinase and Shaker Type Kv1.3 Potassium Channel in T Lymphocytes

1997 • 124 citations

The Movement of Solutes and Cells across Tight Junctionsa

1992 • 106 citations

The SH3 domain of the tight junction protein ZO‐1 binds to a serine protein kinase that phosphorylates a region C‐terminal to this domain

1996 • 102 citations

Protein Kinase C-α Activity Modulates Transepithelial Permeability and Cell Junctions in the LLC-PK1 Epithelial Cell Line

1997 • 90 citations

Differential regulation of skeletal muscle myosin‐II and brush border myosin‐I enzymology and mechanochemistry by bacterially produced tropomyosin isoforms

1994 • 88 citations

PDZ Domains and the Formation of Protein Networks at the Plasma Membrane

1998 • 78 citations

Altered hepatic localization and expression of occludin after common bile duct ligation

1995 • 52 citations

Molecular environment of ZO‐1 in epithelial and non‐epithelial cells

1995 • 46 citations

Chapter 11 Protein Interactions in the Tight Junction: The Role of MAGUK Proteins in Regulating Tight Junction Organization and Function

1996 • 25 citations

Modulation of the junctional integrity by low or high concentrations of cytochalasin B and dihydrocytochalasin B in associated with distinct changes in F-actin and ZO-1

1996 • 16 citations