MAGUK proteins: structure and role in the tight junction

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

1996 • 1,589 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

1997 • 1,371 citations

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

1998 • 1,331 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

1999 • 1,094 citations

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

1995 • 994 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1991 • 902 citations

Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments

1997 • 659 citations

Vascular Endothelial Growth Factor Induces Rapid Phosphorylation of Tight Junction Proteins Occludin and Zonula Occluden 1

1999 • 653 citations

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

1997 • 625 citations

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin

1998 • 592 citations

Occludin and claudins in tight-junction strands: leading or supporting players?

1999 • 575 citations

The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy.

1993 • 567 citations

Heteromultimerization and NMDA Receptor-Clustering Activity of Chapsyn-110, a Member of the PSD-95 Family of Proteins

1996 • 539 citations

The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein

1998 • 521 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3

1998 • 508 citations

GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules

1997 • 503 citations

Direct Association of the Gap Junction Protein Connexin-43 with ZO-1 in Cardiac Myocytes

1998 • 492 citations

Afadin: A Novel Actin Filament–binding Protein with One PDZ Domain Localized at Cadherin-based Cell-to-Cell Adherens Junction

1997 • 473 citations

Protein Interactions at the Tight Junction

1999 • 470 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression

2000 • 437 citations

Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity.

1986 • 433 citations

SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A.

1993 • 415 citations

Assembly of the tight junction: the role of diacylglycerol.

1993 • 381 citations

Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cells.

1988 • 366 citations

The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.

1996 • 353 citations

Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2

2000 • 350 citations

Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions.

1996 • 335 citations

Evidence that tyrosine phosphorylation may increase tight junction permeability

1995 • 318 citations

The Ras Target AF-6 Interacts with ZO-1 and Serves as a Peripheral Component of Tight Junctions in Epithelial Cells

1997 • 315 citations

Characterization of ZO-2 as a MAGUK Family Member Associated with Tight as well as Adherens Junctions with a Binding Affinity to Occludin and α Catenin

1999 • 302 citations

Tight junction formation in cultured epithelial cells (MDCK)

1985 • 298 citations

Cingulin Contains Globular and Coiled-Coil Domains and Interacts with Zo-1, Zo-2, Zo-3, and Myosin

1999 • 294 citations

Interferon-γ decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin

1999 • 281 citations

Assembly and sealing of tight junctions: Possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin

1991 • 280 citations

Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells

1992 • 280 citations

Occludin confers adhesiveness when expressed in fibroblasts

1997 • 272 citations

Binding of the Inward Rectifier K+ Channel Kir 2.3 to PSD-95 Is Regulated by Protein Kinase A Phosphorylation

1996 • 265 citations

Regulated assembly of tight junctions by protein kinase C.

1995 • 262 citations

Regulation of the TRP Ca2+ Channel by INAD in Drosophila Photoreceptors

1996 • 256 citations

Evidence for PDZ domains in bacteria, yeast, and plants

1997 • 237 citations

A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites.

1991 • 234 citations

An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.

1994 • 221 citations

The Junction-associated Protein AF-6 Interacts and Clusters with Specific Eph Receptor Tyrosine Kinases at Specialized Sites of Cell–Cell Contact in the Brain

1999 • 195 citations

Tight Junction Proteins Form Large Complexes and Associate with the Cytoskeleton in an ATP Depletion Model for Reversible Junction Assembly

1997 • 189 citations

Two classes of tight junctions are revealed by ZO-1 isoforms

1993 • 189 citations

Loss of the Tight Junction MAGUK ZO-1 in Breast Cancer

1998 • 185 citations

Localization and differential expression of two isoforms of the tight junction protein ZO-1

1992 • 168 citations

SH3 domains and drug design: Ligands, structure, and biological function

1997 • 164 citations

Detection of the tight junction-associated protein ZO-1 in astrocytes and other nonepithelial cell types

1992 • 162 citations

Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 α+ isoform

1997 • 160 citations

Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions

1999 • 159 citations

Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia

1998 • 152 citations

Identification of an Intramolecular Interaction between the SH3 and Guanylate Kinase Domains of PSD-95

1999 • 150 citations

Cortactin Associates with the Cell-Cell Junction Protein ZO-1 in both Drosophila and Mouse

1998 • 141 citations

Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells

1995 • 128 citations

Identification of Isoforms of G Proteins and PKC that Colocalize with Tight Junctions

1996 • 127 citations

CIPP, a Novel Multivalent PDZ Domain Protein, Selectively Interacts with Kir4.0 Family Members, NMDA Receptor Subunits, Neurexins, and Neuroligins

1998 • 125 citations

Occluding Junctions in MDCK Cells: Modulation of Transepithelial Permeability by the Cytoskeleton

1982 • 114 citations

Diversity among tight junctions in rat kidney: glomerular slit diaphragms and endothelial junctions express only one isoform of the tight junction protein ZO-1.

1992 • 113 citations

Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance

1989 • 108 citations

Direct binding between two PDZ domain proteins Canoe and ZO-1 and their roles in regulation of the Jun N-terminal kinase pathway in Drosophila morphogenesis

1998 • 106 citations

The SH3 domain of the tight junction protein ZO‐1 binds to a serine protein kinase that phosphorylates a region C‐terminal to this domain

1996 • 102 citations

The Tight Junction Protein ZO-2 Contains Three PDZ (PSD-95Discs-LargeZO-1) Domains and an Alternatively Spliced Region

1996 • 99 citations

BEGAIN (Brain-enriched Guanylate Kinase-associated Protein), a Novel Neuronal PSD-95/SAP90-binding Protein

1998 • 90 citations

The making of a tight junction

1993 • 90 citations

Protein Kinase C-α Activity Modulates Transepithelial Permeability and Cell Junctions in the LLC-PK1 Epithelial Cell Line

1997 • 90 citations

Interaction of NE-dlg/SAP102, a Neuronal and Endocrine Tissue-specific Membrane-associated Guanylate Kinase Protein, with Calmodulin and PSD-95/SAP90

1999 • 88 citations

Tight junctions and apical/basolateral polarity

1989 • 87 citations

Cytoskeletal involvement in the modulation of cell-cell junctions by the protein kinase inhibitor H-7

1994 • 79 citations

The Drosophila tamou gene, a component of the activating pathway of extramacrochaetae expression, encodes a protein homologous to mammalian cell-cell junction-associated protein ZO-1.

1996 • 74 citations

Overexpression of protein kinase C-δ increases tight junction permeability in LLC-PK₁epithelia

1998 • 74 citations

Three-dimensional structure of the complex of guanylate kinase from yeast with its substrate GMP

1990 • 73 citations

Nucleotide bindind by the synapse associated protein SAP90

1995 • 73 citations

Connexin-Occludin Chimeras Containing the Zo-Binding Domain of Occludin Localize at Mdck Tight Junctions and Nrk Cell Contacts

1999 • 67 citations

In VivoInteraction of AF-6 with Activated Ras and ZO-1

1999 • 63 citations

Tight junction protein zo-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma

1999 • 60 citations

Analysis of the distribution and phosphorylation state of ZO-1 in MDCK and nonepithelial cells

1994 • 53 citations

Effects of Tyrosine Phosphorylation on Tight Junctions in Temperature-Sensitive v-src-transfected MDCK Cells.

1995 • 53 citations

Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites

1994 • 51 citations

Molecular Characterization of the Tight Junction Protein ZO-1 in MDCK Cells

1999 • 50 citations

Molecular environment of ZO‐1 in epithelial and non‐epithelial cells

1995 • 46 citations

Effect of hepatocyte growth factor on assembly of zonula occludens-1 protein at the plasma membrane

1998 • 46 citations

Differential Distribution of the Tight-Junction-Associated Protein ZO-1 Isoforms α+ and α- in Guinea Pig Sertoli Cells: A Possible Association with F-Actin and G-Actin1

1997 • 41 citations

zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells

1999 • 31 citations

Activation of channel activity of the NMDA receptor‐PSD‐95 complex by guanylate kinase‐associated protein (GKAP)

1999 • 21 citations

Protein-Binding Domains of the Tight Junction Protein, ZO-2, Are Highly Conserved between Avian and Mammalian Species

1998 • 14 citations