Regulation of Tight Junction Permeability and Occludin Phosphorylation by RhoA-p160ROCK-dependent and -independent Mechanisms

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

1998 • 1,331 citations

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

1999 • 1,100 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.

1996 • 804 citations

Vascular Endothelial Growth Factor Induces Rapid Phosphorylation of Tight Junction Proteins Occludin and Zonula Occluden 1

1999 • 653 citations

Occludin as a possible determinant of tight junction permeability in endothelial cells

1997 • 626 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin

1998 • 592 citations

Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation

1997 • 576 citations

Occludin and claudins in tight-junction strands: leading or supporting players?

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Structure, biochemistry, and assembly of epithelial tight junctions

1987 • 532 citations

REGULATION OF THE MOVEMENT OF SOLUTES ACROSS TIGHT JUNCTIONS

1998 • 526 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

Cingulin, a new peripheral component of tight junctions

1988 • 505 citations

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation.

1995 • 451 citations

Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

1995 • 418 citations

Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions

1999 • 411 citations

Breaking through the tight junction barrier.

1993 • 379 citations

Rho effectors and reorganization of actin cytoskeleton

1997 • 379 citations

Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases

1998 • 349 citations

Thrombin Inactivates Myosin Light Chain Phosphatase via Rho and Its Target Rho Kinase in Human Endothelial Cells

1998 • 348 citations

Evidence that tyrosine phosphorylation may increase tight junction permeability

1995 • 318 citations

Characterization of ZO-2 as a MAGUK Family Member Associated with Tight as well as Adherens Junctions with a Binding Affinity to Occludin and α Catenin

1999 • 302 citations

Symplekin, a novel type of tight junction plaque protein.

1996 • 286 citations

Mammalian occludin in epithelial cells: its expression and subcellular distribution.

1997 • 278 citations

Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2.

1993 • 266 citations

Endothelial Gaps as Sites for Plasma Leakage in Inflammation

1999 • 222 citations

Transformation mediated by RhoA requires activity of ROCK kinases

1999 • 209 citations

Expression and polarized targeting of a rab3 isoform in epithelial cells.

1994 • 179 citations

Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

1997 • 172 citations

Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA

1997 • 155 citations

Identification of a Novel, Putative Rho-specific GDP/GTP Exchange Factor and a RhoA-binding Protein: Control of Neuronal Morphology

1997 • 154 citations

Endothelial Gaps as Sites for Plasma Leakage in Inflammation

1999 • 121 citations

Cell adhesion, cell junctions and the blood—brain barrier

1996 • 110 citations

Occludin dephosphorylation in early development of Xenopus laevis

1997 • 89 citations

Pasteurella multocida Toxin Increases Endothelial Permeability via Rho Kinase and Myosin Light Chain Phosphatase

1998 • 70 citations

Dephosphorylation of the catenins p120 and p100 in endothelial cells in response to inflammatory stimuli

1999 • 68 citations

Effects of cytoskeletal disrupting agents on replication of bovine endothelium

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[26] Phosphorylation of phospholipase C in vivo and in vitro

1991 • 17 citations