Dominant role of cAMP in regulation of microvessel permeability

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

The Cytoskeleton and Cell Signaling: Component Localization and Mechanical Coupling

1998 • 783 citations

Microvascular Permeability

1999 • 769 citations

VEGF induces NO-dependent hyperpermeability in coronary venules

1996 • 247 citations

VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway

1999 • 229 citations

cGMP and Nitric Oxide Modulate Thrombin-Induced Endothelial Permeability

1995 • 201 citations

Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular cAMP levels

1992 • 197 citations

Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade

1993 • 174 citations

Microvascular permeability and number of tight junctions are modulated by cAMP

1998 • 144 citations

Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3′,5′-cyclic nucleotide phosphodiesterase

1997 • 138 citations

Role of nitric oxide and phosphodiesterase isoenzyme II for reduction of endothelial hyperpermeability

1996 • 133 citations

TNF modulates endothelial properties by decreasing cAMP

1995 • 111 citations

Cyclic-GMP-Mediated Decrease in Permeability of Human Umbilical and Pulmonary Artery Endothelial Cell Monolayers

1994 • 96 citations

Capillary hydraulic conductivity is elevated by cGMP-dependent vasodilators.

1992 • 84 citations

Histamine and inositol phosphate accumulation in endothelium: cAMP and a G protein

1989 • 83 citations

Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: effects on platelet aggregation

1997 • 82 citations

Differential actions of cAMP on endothelial [Ca2+]i and permeability in microvessels exposed to ATP

1993 • 69 citations

Nitric oxide-induced microvascular permeability alterations: a regulatory role for cGMP

1993 • 68 citations

cGMP modulates basal and activated microvessel permeability independently of [Ca²⁺]_i

1998 • 67 citations

Ca2+ entry through conductive pathway modulates receptor-mediated increase in microvessel permeability

1996 • 63 citations

Effect of nitric oxide synthase inhibitors on endothelial [Ca2+]i and microvessel permeability

1997 • 58 citations

Test of a two-pathway model for small-solute exchange across the capillary wall

1998 • 56 citations

Protein kinase C modulates microvascular permeability through nitric oxide synthase

1996 • 56 citations

Role of nitric oxide in histamine-induced increases in permeability of the blood–brain barrier

1996 • 53 citations

Cross Talk Among Cyclic AMP, Cyclic GMP, and Ca²⁺ ‐Dependent Intracellular Signalling Mechanisms in Brain Capillary Endothelial Cells

1994 • 52 citations

Substance P increases microvascular permeability via nitric oxide-mediated convective pathways

1995 • 46 citations

Filamin translocation is an early endothelial cell inflammatory response to bradykinin: regulation by calcium, protein kinases, and protein phosphatases.

1996 • 46 citations

Functional antagonism between cAMP and cGMP on permeability of coronary endothelial monolayers

1996 • 41 citations

Modulation of barrier function of bovine aortic and pulmonary artery endothelial cells: dissociation from cytosolic calcium content

1992 • 40 citations

Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic-3',5'-guanosine monophosphate-stimulated phosphodiesterase to reverse hypoxic pulmonary vasoconstriction in the perfused rat lung.

1996 • 40 citations

Effects of ATP and bradykinin on endothelial cell Ca2+ homeostasis and formation of cGMP and prostacyclin

1993 • 39 citations

Filamin translocation is an early endothelial cell inflammatory response to bradykinin: Regulation by calcium, protein kinases, and protein phosphatases

1996 • 36 citations

Identification and Possible Localization of cGMP-Dependent Protein Kinase in Bovine Aortic Endothelial Cells

1994 • 34 citations

Effect of nitric oxide synthase inhibitors on basal microvessel permeability and endothelial cell [Ca2+]i

1997 • 34 citations

Platelet-Activating Factor and Nitric Oxide Mediate Microvascular Permeability in Ischemia-Reperfusion Injury

1996 • 26 citations

Cyclic GMP-Dependent Protein Kinase Activity in Rat Pulmonary Microvascular Endothelial Cells

1994 • 24 citations