Endothelial cell–cell junctions: happy together

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Wnt signaling and cancer

2000 • 3,215 citations

Multifunctional strands in tight junctions

2001 • 2,392 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

2003 • 1,705 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Linking Colorectal Cancer to Wnt Signaling

2000 • 1,507 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

1999 • 1,291 citations

Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands

2000 • 1,118 citations

Tight junctions of the blood–brain barrier

2002 • 1,108 citations

Cytoskeletal regulation of pulmonary vascular permeability

2001 • 954 citations

Cadherins in cancer: implications for invasion and metastasis

1993 • 939 citations

Signalling to and from tight junctions

2003 • 863 citations

Leukocyte–endothelial-cell interactions in leukocyte transmigration and the inflammatory response

2003 • 798 citations

Regulation of Cadherin Adhesive Activity

2000 • 793 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis

1999 • 752 citations

A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

2001 • 729 citations

Developmental Defects in Mouse Embryos Lacking N-Cadherin

1997 • 712 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells

1998 • 695 citations

The biology of PECAM-1.

1997 • 669 citations

Tube Morphogenesis

2003 • 657 citations

The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy.

1993 • 567 citations

P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases

2000 • 563 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

The Wnt signalling pathway

2002 • 534 citations

Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions

1998 • 532 citations

E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

2001 • 532 citations

Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein

1999 • 527 citations

A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor

2002 • 498 citations

CD99 plays a major role in the migration of monocytes through endothelial junctions

2002 • 497 citations

Endothelial cell‐to‐cell junctions

1995 • 481 citations

E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1

1998 • 451 citations

Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions

1999 • 430 citations

Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP

1998 • 415 citations

Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, β-catenin, and the phosphatase DEP-1/CD148

2003 • 403 citations

The ZO-1–associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density

2003 • 400 citations

Regulation of TNF-α-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells

1998 • 390 citations

The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)

2001 • 387 citations

Junctional adhesion molecule (JAM) binds to PAR-3

2001 • 379 citations

Thrombin Inactivates Myosin Light Chain Phosphatase via Rho and Its Target Rho Kinase in Human Endothelial Cells

1998 • 348 citations

Molecular Structure of Tight Junctions and Their Role in Epithelial Transport

2001 • 347 citations

Signaling from E-cadherins to the MAPK Pathway by the Recruitment and Activation of Epidermal Growth Factor Receptors upon Cell-Cell Contact Formation

2000 • 345 citations

Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer

1998 • 343 citations

Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells.

1993 • 340 citations

Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke

2001 • 336 citations

Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions.

1996 • 335 citations

VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells

2002 • 329 citations

Cell–cell adhesion and signalling

2002 • 327 citations

Cadherins and tissue formation: integrating adhesion and signaling

1999 • 318 citations

Molecular Mechanisms Of Tubulogenesis

2002 • 318 citations

Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.

1995 • 313 citations

Protein modules as organizers of membrane structure

1999 • 311 citations

The conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility

2003 • 308 citations

VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts

2002 • 303 citations

Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis

2003 • 302 citations

Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction

2002 • 301 citations

Lymphocyte Migration Through Brain Endothelial Cell Monolayers Involves Signaling Through Endothelial ICAM-1 Via a Rho-Dependent Pathway

1999 • 299 citations

Differential Localization of VE- and N-Cadherins in Human Endothelial Cells: VE-Cadherin Competes with N-Cadherin for Junctional Localization

1998 • 297 citations

Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion

2001 • 296 citations

Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition

2000 • 290 citations

Leukocyte Recruitment in the Cerebrospinal Fluid of Mice with Experimental Meningitis Is Inhibited by an Antibody to Junctional Adhesion Molecule (Jam)

1999 • 288 citations

Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin.

1985 • 286 citations

The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides

2002 • 277 citations

Cadherin-mediated cellular signaling

2003 • 275 citations

Activation of the Protein Kinase Akt/PKB by the Formation of E-cadherin-mediated Cell-Cell Junctions

1999 • 268 citations

The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation

1996 • 266 citations

Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members

2001 • 261 citations

Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex.

1996 • 251 citations

Interactions between mitogenic stimuli, or, a thousand and one connections

1999 • 246 citations

Mechanisms regulating endothelial cell barrier function

2000 • 244 citations

VE-Cadherin Regulates Endothelial Actin Activating Rac and Increasing Membrane Association of Tiam

2002 • 241 citations

PECAM-1: old friend, new partners

2003 • 239 citations

Regulation of the Actin Cytoskeleton by Thrombin in Human Endothelial Cells: Role of Rho Proteins in Endothelial Barrier Function

1998 • 238 citations

Vascular Endothelial (VE)-Cadherin: Only an Intercellular Glue?

1999 • 238 citations

VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration

2003 • 229 citations

Adhesion signaling: How β-catenin interacts with its partners

2001 • 225 citations

Cell Contact-Dependent Signaling

1996 • 225 citations

Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin.

1996 • 221 citations

SHP2 Association with VE-Cadherin Complexes in Human Endothelial Cells Is Regulated by Thrombin

2000 • 212 citations

N-Cadherin Extracellular Repeat 4 Mediates Epithelial to Mesenchymal Transition and Increased Motility

2000 • 201 citations

A monoclonal antibody to vascular endothelial–cadherin inhibits tumor angiogenesis without side effects on endothelial permeability

2002 • 191 citations

The parting of the endothelium: miracle, or simply a junctional affair?

2000 • 186 citations

Endothelial-dependent Mechanisms Regulate Leukocyte Transmigration: A Process Involving the Proteasome and Disruption of the Vascular Endothelial–Cadherin Complex at Endothelial Cell-to-Cell Junctions

1997 • 182 citations

Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature

2001 • 181 citations

The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in theDrosophilatracheal system

2003 • 169 citations

Cadherin Engagement Inhibits RhoA via p190RhoGAP

2003 • 164 citations

Molecular Physiology and Pathophysiology of Tight Junctions I. Biogenesis of tight junctions and epithelial polarity

2000 • 163 citations

Rac Regulates Endothelial Morphogenesis and Capillary Assembly

2002 • 160 citations

Adhesive But Not Lateral E-cadherin Complexes Require Calcium and Catenins for Their Formation

1998 • 154 citations

The PDZ Domains of Zonula Occludens-1 Induce an Epithelial to Mesenchymal Transition of Madin-Darby Canine Kidney I Cells

2000 • 150 citations

Transmembrane proteins of tight junctions

2000 • 147 citations

Intracellular Domain of Brain Endothelial Intercellular Adhesion Molecule-1 Is Essential for T Lymphocyte-Mediated Signaling and Migration

2003 • 144 citations

WNT Signaling and Lymphocyte Development

2002 • 137 citations

PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis

2003 • 128 citations

Complexus adhaerentes, a new group of desmoplakin-containing junctions in endothelial cells: the syndesmos connecting retothelial cells of lymph nodes.

1993 • 127 citations

Involvement of nectin in the localization of junctional adhesion molecule at tight junctions

2002 • 123 citations

Regulation of endothelial cell contacts during leukocyte extravasation

2002 • 122 citations

Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and β-catenin

2002 • 119 citations

Cell-Junctional and Cytoskeletal Organization in Mouse Blastocysts Lacking E-Cadherin

1997 • 118 citations

Role of myosin light-chain phosphorylation in endothelial cell retraction

1993 • 117 citations

huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell–cell tight junctions

2000 • 114 citations

Confluence of Vascular Endothelial Cells Induces Cell Cycle Exit by Inhibiting p42/p44 Mitogen-Activated Protein Kinase Activity

1999 • 108 citations

A Mutant Receptor Tyrosine Phosphatase, CD148, Causes Defects in Vascular Development

2003 • 105 citations

Lack of Platelet Endothelial Cell Adhesion Molecule-1 Attenuates Foreign Body Inflammation because of Decreased Angiogenesis

2003 • 93 citations

Antibodies to the Junctional Adhesion Molecule Cause Disruption of Endothelial Cells and Do Not Prevent Leukocyte Influx into the Meninges after Viral or Bacterial Infection

2000 • 90 citations

Vascular Endothelial Growth Factor Induces Shc Association With Vascular Endothelial Cadherin

2002 • 72 citations

Endothelial adhesion molecules in the development of the vascular tree: the garden of forking paths

1999 • 72 citations

Differential movements of VE-cadherin and PECAM-1 during transmigration of polymorphonuclear leukocytes through human umbilical vein endothelium

2002 • 71 citations

A comparative evaluation of β-catenin and plakoglobin signaling activity

2000 • 65 citations

p21WAF1 regulates anchorage-independent growth of HCT116 colon carcinoma cells via E-cadherin expression.

2000 • 63 citations

Pores in the sieve and channels in the wall: control of paracellular permeability by junctional proteins in endothelial cells.

2001 • 59 citations

Pores in the Sieve and Channels in the Wall: Control of Paracellular Permeability by Junctional Proteins in Endothelial Cells

2001 • 52 citations

Morphogenesis of Endothelium

2000 • 42 citations

Morphogenesis of Endothelium

2002 • 28 citations