Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Progressive sequence alignment as a prerequisitetto correct phylogenetic trees

1987 • 1,899 citations

Transcription and Translation — A Practical Approach

1985 • 811 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

cDNA eloping of bovine substance-K receptor through oocyte expression system

1987 • 748 citations

[25] In vitro RNA synthesis with SP6 RNA polymerase

1987 • 732 citations

Production of diglyceride from phosphatidylinositol in activated human platelets.

1979 • 727 citations

How signal sequences maintain cleavage specificity

1984 • 725 citations

The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin

1990 • 718 citations

Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor

1988 • 691 citations

Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140

1989 • 653 citations

Platelets in Biology and Pathology

1981 • 644 citations

Mitogenic activity of blood components. I. Thrombin and prothrombin.

1975 • 481 citations

Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin.

1988 • 409 citations

Structural features required for ligand binding to the beta-adrenergic receptor.

1987 • 358 citations

Interrelations of Platelet Aggregation and Secretion

1977 • 350 citations

Monocyte Chemotaxis: Stimulation by Specific Exosite Region in Thrombin

1983 • 333 citations

D-PHE-PRO-ARGCH2Cl-A selective affinity label for thrombin

1979 • 327 citations

Actions of Thrombin and Other Coagulant and Proteolytic Enzymes on Blood Platelets

1967 • 314 citations

The Binding of Thrombin to the Surface of Human Platelets

1974 • 311 citations

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding

1978 • 301 citations

Characterization of a new megakaryocytic cell line: the Dami cell

1988 • 286 citations

Crystal structure of bovine trypsinogen at 1·8 Å resolution

1977 • 242 citations

Thrombin is an important mediator of platelet aggregation in stenosed canine coronary arteries with endothelial injury.

1989 • 241 citations

Thrombin stimulates c-sis gene expression in microvascular endothelial cells.

1986 • 235 citations

Characterization of a new megakaryocytic cell line: the Dami cell

1988 • 220 citations

Role of extracellular disulfide-bonded cysteines in the ligand binding function of the .beta.2-adrenergic receptor

1990 • 215 citations

[12] Isolation of human platelets and platelet surface membranes

1974 • 213 citations

Platelet glycocalicin. Interaction with thrombin and role as thrombin receptor of the platelet surface.

1978 • 209 citations

Thrombin‐Cellular Interactions

1986 • 202 citations

Chemistry and biology of thrombin

1978 • 198 citations

The molecular cloning and characterisation of cDNA coding for the α subunit of the acetyl-choline receptor

1982 • 176 citations

Kinetics of the thrombin-induced release of calcium(II) by platelets

1973 • 164 citations

Site-directed Mutagenesis of β-Adrenergic Receptors

1989 • 155 citations

Kinetics of the thrombin-induced release of adenosine triphosphate by platelets. Comparison with release of calcium

1973 • 118 citations

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.

1989 • 117 citations

Amino acid sequence of the heavy chain of bovine protein C.

1982 • 110 citations

Mitogenicity of thrombin and surface alterations on mouse splenocytes

1976 • 108 citations

Platelet stimulation by thrombin and other proteases

1975 • 106 citations

Constitutive and inducible secretion of platelet-derived growth factor analogs by human leukemic cell lines coexpressing erythroid and megakaryocytic markers.

1987 • 95 citations

Structure-function relationships in the interaction of alpha-thrombin with blood platelets.

1977 • 77 citations

Inhibition of coagulation and thrombin-induced platelet activities by a synthetic dodecapeptide modeled on the carboxy-terminus of hirudin

1990 • 74 citations

Thrombin Stimulates Neutrophil Adherence by an Endothelial Cell‐Dependent Mechanism: Characterization of the Response and Relationship to Platelet‐Activating Factor Synthesis^a

1986 • 70 citations

Localization of thrombin cleavage sites in the amino-terminal region of bovine protein S.

1986 • 69 citations

Expression of receptors for cholecystokinin and other Ca2+-mobilizing hormones in Xenopus oocytes.

1988 • 68 citations

Inhibition of coagulation and thrombin-induced platelet activities by a synthetic dodecapeptide modeled on the carboxy-terminus of hirudin

1990 • 66 citations

Thrombin interaction with platelets. Influence of a platelet protease nexin.

1987 • 59 citations

Homologous desensitization of thrombin-induced phosphoinositide breakdown in hamster lung fibroblasts.

1988 • 57 citations

Thrombin Interactions with Platelet Membrane Proteins^a

1986 • 49 citations

The mechanism of the fibrinogen-thrombin reaction

1978 • 47 citations

Thrombin-Induced Platelet Secretion

1979 • 42 citations

Secreted alkaline phosphatase: an internal standard for expression of injected mRNAs in the Xenopus oocyte

1990 • 40 citations

Thrombin Interaction with Human Platelets Potentiation of Thrombin-induced Aggregation and Release by Inactivated Thrombin

1974 • 30 citations

Functional expression of Ca²⁺ ‐mobilizing α‐thrombin receptors in mRNA‐injected Xenopus oocytes

1990 • 18 citations

Expression of functional thrombin receptors in Xenopus oocytes injected with human endothelial cell mRNA

1990 • 11 citations