Beyond the gap: functions of unpaired connexon channels

DISCHARGE PATTERNS AND FUNCTIONAL ORGANIZATION OF MAMMALIAN RETINA

1953 • 2,579 citations

Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

1999 • 1,684 citations

The mechanism of directionally selective units in rabbit's retina.

1965 • 1,555 citations

HEXAGONAL ARRAY OF SUBUNITS IN INTERCELLULAR JUNCTIONS OF THE MOUSE HEART AND LIVER

1967 • 1,482 citations

Connexin 26 mutations in hereditary non-syndromic sensorineural deafness

1997 • 1,435 citations

Organization of the retina of the mudpuppy, Necturus maculosus. II. Intracellular recording.

1969 • 1,378 citations

Cardiac Malformation in Neonatal Mice Lacking Connexin43

1995 • 1,242 citations

Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome

2002 • 1,157 citations

Connexin43: a protein from rat heart homologous to a gap junction protein from liver.

1987 • 1,111 citations

Connexin Mutations in X-Linked Charcot-Marie-Tooth Disease

1993 • 1,055 citations

Multicolor and Electron Microscopic Imaging of Connexin Trafficking

2002 • 908 citations

Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin

1999 • 887 citations

Intercellular Calcium Signaling in Astrocytes via ATP Release through Connexin Hemichannels

2002 • 836 citations

Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells.

1995 • 821 citations

ATP Released from Astrocytes Mediates Glial Calcium Waves

1999 • 794 citations

Emerging issues of connexin channels: biophysics fills the gap

2001 • 785 citations

Connexins regulate calcium signaling by controlling ATP release

1998 • 767 citations

Female infertility in mice lacking connexin 37

1997 • 726 citations

Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques.

1991 • 705 citations

Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes.

1991 • 600 citations

Three-Dimensional Structure of a Recombinant Gap Junction Membrane Channel

1999 • 532 citations

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

2001 • 530 citations

Regulation of Gap Junctions by Phosphorylation of Connexins

2000 • 521 citations

Inhibitory effect of dibutyryl cAMP on mouse oocyte maturation in vitro

1974 • 498 citations

Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER

1993 • 492 citations

Transmission of hormonal stimulation by cell-to-cell communication

1978 • 490 citations

Connexin 43 hemichannels mediate Ca2+‐regulated transmembrane NAD+ fluxes in intact cells

2000 • 450 citations

Connexin36 Is Essential for Transmission of Rod-Mediated Visual Signals in the Mammalian Retina

2002 • 420 citations

Disruption of α3 Connexin Gene Leads to Proteolysis and Cataractogenesis in Mice

1997 • 415 citations

MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-XL, and Mcl-1 and promotes survival of human pancreatic cancer cells

2000 • 403 citations

GENETIC DISEASES AND GENE KNOCKOUTS REVEAL DIVERSE CONNEXIN FUNCTIONS

1999 • 399 citations

Connexin43 Deficiency Causes Delayed Ossification, Craniofacial Abnormalities, and Osteoblast Dysfunction

2000 • 393 citations

ATP-Mediated Glia Signaling

2000 • 391 citations

Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice.

1996 • 382 citations

A Missense Mutation in the Human Connexin50 Gene (GJA8) Underlies Autosomal Dominant “Zonular Pulverulent” Cataract, on Chromosome 1q

1998 • 373 citations

Hemichannel-Mediated Inhibition in the Outer Retina

2001 • 366 citations

Mechanical stimulation and intercellular communication increases intracellular Ca2+ in epithelial cells.

1990 • 363 citations

Targeted Ablation of Connexin50 in Mice Results in Microphthalmia and Zonular Pulverulent Cataracts

1998 • 354 citations

Depolarization Without Calcium Can Release γ-Aminobutyric Acid from a Retinal Neuron

1987 • 352 citations

Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies.

1992 • 351 citations

Transduction of Cell Survival Signals by Connexin-43 Hemichannels

2002 • 332 citations

The Mood Stabilizer Valproic Acid Activates Mitogen-activated Protein Kinases and Promotes Neurite Growth

2001 • 332 citations

Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells.

1996 • 327 citations

Carbon dioxide reversibly abolishes ionic communication between cells of early amphibian embryo

1977 • 323 citations

Calcium waves in astrocytes-filling in the gaps

1992 • 321 citations

Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells

2002 • 316 citations

Intercellular calcium signaling via gap junctions in glioma cells.

1992 • 316 citations

Isoform Composition of Connexin Channels Determines Selectivity among Second Messengers and Uncharged Molecules

1998 • 307 citations

Physiological Role of Gap-Junctional Hemichannels

2000 • 305 citations

Connexin46 Mutations in Autosomal Dominant Congenital Cataract

1999 • 299 citations

Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins.

1994 • 286 citations

Functional Gap Junctions in the Schwann Cell Myelin Sheath

1998 • 277 citations

Hemi‐gap‐junction channels in solitary horizontal cells of the catfish retina.

1992 • 276 citations

Modulation of an electrical synapse between solitary pairs of catfish horizontal cells by dopamine and second messengers.

1989 • 274 citations

Gap junctions, electrotonic coupling, and intercellular communication.

1978 • 267 citations

Connexin-43 Hemichannels Opened by Metabolic Inhibition

1999 • 263 citations

Selectivity of Connexin-Specific Gap Junctions Does Not Correlate With Channel Conductance

1995 • 258 citations

Mechanism Involved in Initiation and Propagation of Receptor-Induced Intercellular Calcium Signaling in Cultured Rat Astrocytes

1997 • 254 citations

Apoptosis and osteoporosis

2000 • 251 citations

Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells.

1994 • 240 citations

The Sleep-inducing Lipid Oleamide Deconvolutes Gap Junction Communication and Calcium Wave Transmission in Glial Cells

1997 • 236 citations

Properties of a nonjunctional current expressed from a rat connexin46 cDNA in Xenopus oocytes.

1993 • 235 citations

Selective Disruption of Gap Junctional Communication Interferes with a Patterning Process in Hydra

1987 • 227 citations

Molecular biology and genetics of gap junction channels

1992 • 225 citations

Trafficking, Assembly, and Function of a Connexin43-Green Fluorescent Protein Chimera in Live Mammalian Cells

1999 • 204 citations

Intercellular Communication in Spinal Cord Astrocytes: Fine Tuning between Gap Junctions and P2 Nucleotide Receptors in Calcium Wave Propagation

2000 • 192 citations

Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis

2001 • 191 citations

Metabolic Inhibition Activates a Non-selective Current Through Connexin Hemichannels in Isolated Ventricular Myocytes

2000 • 190 citations

The origin of annular junctions: a mechanism of gap junction internalization

2001 • 188 citations

Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cells

1999 • 182 citations

A quantitative analysis of connexin-specific permeability differences of gap junctions expressed in HeLa transfectants and Xenopus oocytes

1998 • 174 citations

Interaction of c-Src with Gap Junction Protein Connexin-43

2001 • 173 citations

Connexins: a connection with the skin

2000 • 172 citations

Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26

2003 • 154 citations

Inhibition of Gap Junction Hemichannels by Chloride Channel Blockers

2002 • 151 citations

Rapid and Direct Effects of pH on Connexins Revealed by the Connexin46 Hemichannel Preparation

1999 • 151 citations

Xenopus connexin38 forms hemi-gap-junctional channels in the nonjunctional plasma membrane of Xenopus oocytes

1996 • 147 citations

Intercellular Calcium Signaling Occurs between Human Osteoblasts and Osteoclasts and Requires Activation of Osteoclast P2X7 Receptors

2002 • 145 citations

Biophysical Properties of Connexin-45 Gap Junction Hemichannels Studied in Vertebrate Cells

2002 • 140 citations

Connexin 43 (cx43) enhances chemotherapy-induced apoptosis in human glioblastoma cells

2001 • 137 citations

Synaptic organization and ionic basis of on and off channels in mudpuppy retina. I. Intracellular analysis of chloride-sensitive electrogenic properties of receptors, horizontal cells, bipolar cells, and amacrine cells.

1976 • 136 citations

Growth factors but not gap junctions play a role in injury-induced Ca2+ waves in epithelial cells

2001 • 133 citations

Visualization and functional blocking of gap junction hemichannels (connexons) with antibodies against external loop domains in astrocytes

1998 • 132 citations

Connexin 50 mutation in a family with congenital "zonular nuclear" pulverulent cataract of Pakistani origin

1999 • 131 citations

Distinct behavior of connexin56 and connexin46 gap junctional channels can be predicted from the behavior of their hemi-gap-junctional channels

1995 • 130 citations

Conductances and Selective Permeability of Connexin43 Gap Junction Channels Examined in Neonatal Rat Heart Cells

1997 • 130 citations

Evidence of a role for cyclic ADP‐ribose in calcium signalling and neurotransmitter release in cultured astrocytes

2001 • 128 citations

Extent of intercellular calcium wave propagation is related to gap junction permeability and level of connexin-43 expression in astrocytes in primary cultures from four brain regions

1999 • 128 citations

Connexin-specific distribution within gap junctions revealed in living cells

2000 • 125 citations

Hormonal regulation of intercellular communication: parathyroid hormone increases connexin 43 gene expression and gap-junctional communication in osteoblastic cells.

1992 • 124 citations

Expression of CD38 Increases Intracellular Calcium Concentration and Reduces Doubling Time in HeLa and 3T3 Cells

1998 • 122 citations

Cyclic ADP-Ribose: Metabolism and Calcium Mobilizing Function

1994 • 120 citations

Connexin mimetic peptides reversibly inhibit Ca²⁺signaling through gap junctions in airway cells

2000 • 118 citations

Paracrine Roles of NAD+ and Cyclic ADP-ribose in Increasing Intracellular Calcium and Enhancing Cell Proliferation of 3T3 Fibroblasts

2001 • 115 citations

Cellular mechanisms of connexin32 mutations associated with CNS manifestations

2002 • 114 citations

Electrical feedback mechanism in the processing of signals in the outer plexiform layer of the retina

1986 • 112 citations

Hemichannel and Junctional Properties of Connexin 50

2002 • 111 citations

Human Osteoblastic Cells Propagate Intercellular Calcium Signals by Two Different Mechanisms

2000 • 109 citations

A Self-restricted CD38-connexin 43 Cross-talk Affects NAD+ and Cyclic ADP-ribose Metabolism and Regulates Intracellular Calcium in 3T3 Fibroblasts

2001 • 108 citations

Bone-Resorbing Osteoclasts Contain Gap-Junctional Connexin-43

2000 • 108 citations

Ligand‐induced internalization of CD38 results in intracellular Ca²⁺mobilization: role of NAD⁺transport across cell membranes

1999 • 107 citations

Neurochemistry of the mammalian cone `synaptic complex'

1998 • 103 citations

Heterotypic gap junction channel formation between heteromeric and homomeric Cx40 and Cx43 connexons

2001 • 101 citations

Propagation of Mechanically Induced Intercellular Calcium Waves via Gap Junctions and ATP Receptors in Rat Liver Epithelial Cells

1997 • 99 citations

Activation of Connexin-43 Hemichannels Can Elevate [Ca2+]iand [Na+]iin Rabbit Ventricular Myocytes During Metabolic Inhibition

2001 • 93 citations

Bisphosphonate-Induced, Hemichannel-Mediated, Anti-Apoptosis Through the Src/ERK Pathway: A Gap Junction-Independent Action of Connexin43

2001 • 90 citations

Synthesis and assembly of human β1 gap junctions in BHK cells by DNA transfection with the human β1 cDNA

1995 • 88 citations

Connexin mutations in hearing loss, dermatological and neurological disorders

2002 • 84 citations

The ion selectivity of a membrane conductance inactivated by extracellular calcium in Xenopus oocytes

1998 • 82 citations

Attempts to define functional domains of gap junction proteins with synthetic peptides

1994 • 81 citations

Functional characteristics of skate connexin35, a member of the γ subfamily of connexins expressed in the vertebrate retina

1999 • 80 citations

Selective inhibition of gap junction channel activity by synthetic peptides

1999 • 74 citations

Direct Isolation and Analysis of Endogenous Transjunctional ADP from Cx43 Transfected C6 Glioma Cells

1998 • 71 citations

A monovalent cationic conductance that is blocked by extracellular divalent cations in Xenopus oocytes.

1995 • 71 citations

THE PERMEABILITY OF ISOLATED AND IN SITU MOUSE HEPATIC GAP JUNCTIONS STUDIED WITH ENZYMATIC TRACERS

1971 • 66 citations

Intercellular Ca$^{2+}$ waves in mechanically stimulated articular chondrocytes

2000 • 65 citations

Identification of genes differentially expressed in C6 glioma cells transfected with connexin43

2000 • 54 citations

Connexin hemichannels and cell-cell channels: comparison of properties

2000 • 51 citations

Identification and localization of connexin26 within the photoreceptor-horizontal cell synaptic complex

2001 • 47 citations

Propagation of intercellular calcium waves in C6 glioma cells transfected with connexins 43 or 32

2001 • 45 citations

Single channel behavior of recombinant beta 2 gap junction connexons reconstituted into planar lipid bilayers

1995 • 40 citations

Connexin disorders of the skin.

2001 • 37 citations

Slow intercellular Ca²⁺signaling in wild-type and Cx43-null neonatal mouse cardiac myocytes

2000 • 32 citations

Bisphosphonates in bone diseases other than osteoporosis

2002 • 26 citations

Lateral interaction between vertebrate photoreceptors

1971 • 23 citations