Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Integrins.

1991 • 1,369 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Autophosphorylation of the Focal Adhesion Kinase, ppl25^FAK, Directs SH2-Dependent Binding of pp60^src

1994 • 1,168 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

On the Crawling of Animal Cells

1993 • 1,020 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons

1992 • 895 citations

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.

1994 • 844 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

1991 • 713 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors.

1995 • 619 citations

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.

1991 • 578 citations

pp125^FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk

1995 • 534 citations

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

1994 • 525 citations

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase.

1994 • 516 citations

Focal adhesion kinase (p125FAK): A point of convergence in the action of neuropeptides, integrins, and oncogenes

1992 • 453 citations

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.

1993 • 408 citations

Interaction of Focal Adhesion Kinase with Cytoskeletal Protein Talin

1995 • 393 citations

Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin.

1995 • 382 citations

Expression of focal adhesion kinase gene and invasive cancer

1993 • 335 citations

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.

1994 • 331 citations

Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells.

1994 • 320 citations

Signal transduction for chemotaxis and haptotaxis by matrix molecules in tumor cells.

1990 • 316 citations

Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton

1993 • 277 citations

Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin

1993 • 253 citations

Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase.

1995 • 229 citations

Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.

1994 • 214 citations

Fourier analysis of cell motility: correlation of motility with metastatic potential.

1989 • 191 citations

Identification of Tyr-397 as the Primary Site of Tyrosine Phosphorylation and pp60^src Association in the Focal Adhesion Kinase, pp125^FAK

1995 • 185 citations

Focal adhesion kinase: an integrin-linked protein tyrosine kinase

1993 • 177 citations

Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts.

1988 • 174 citations

Monoclonal antibodies specific for the carboxy terminus of simian virus 40 large T antigen

1984 • 163 citations

Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells.

1992 • 136 citations

A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK.

1994 • 134 citations

Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals.

1995 • 116 citations

Differential Effects of Platelet-derived Growth Factor BB on p125 Focal Adhesion Kinase and Paxillin Tyrosine Phosphorylation and on Cell Migration in Rabbit Aortic Vascular Smooth Muscle Cells and Swiss 3T3 Fibroblasts

1995 • 113 citations

Potential role for focal adhesion kinase in migrating and proliferating keratinocytes near epidermal wounds and in culture.

1994 • 100 citations

The role of integrins during vertebrate development

1995 • 32 citations