Interactions between the innate immune and blood coagulation systems

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

2001 • 5,900 citations

A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong

2003 • 2,271 citations

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

1998 • 2,047 citations

Disseminated Intravascular Coagulation

1999 • 1,959 citations

High-Dose Antithrombin III in Severe Sepsis

2001 • 1,381 citations

Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells

1997 • 1,321 citations

The molecular basis of blood coagulation

1988 • 1,240 citations

Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis.

1989 • 1,199 citations

The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation

1989 • 1,059 citations

Blood-borne tissue factor: Another view of thrombosis

1999 • 982 citations

Efficacy and Safety of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor) in Severe Sepsis

2003 • 931 citations

Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

2002 • 832 citations

CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism

2002 • 722 citations

Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis

2001 • 665 citations

Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis

2001 • 655 citations

The Molecular Basis of Blood Diseases.

1987 • 648 citations

Assembly of the Platelet Prothrombinase Complex Is Linked to Vesiculation of the Platelet Plasma Membrane

1989 • 597 citations

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

2003 • 556 citations

Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock.

1993 • 552 citations

Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

1994 • 508 citations

CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection

2000 • 440 citations

Protein C levels as a prognostic indicator of outcome in sepsis and related diseases

2000 • 422 citations

Nathan And Oski's Hematology Of Infancy And Childhood

2004 • 413 citations

Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor

2000 • 387 citations

Tumor Necrosis Factor Suppresses Transcription of the Thrombomodulin Gene in Endothelial Cells

1988 • 367 citations

Plasma thrombomodulin in health and diseases

1990 • 357 citations

Nathan and Oski's Hematology of Infancy and Childhood

2002 • 347 citations

The molecular basis of blood diseases

1988 • 341 citations

The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways

2002 • 331 citations

Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor

2000 • 324 citations

Plasma thrombomodulin in health and diseases

1990 • 296 citations

Bench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis.

2002 • 292 citations

Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells.

1988 • 284 citations

Treatment of Homozygous Protein C Deficiency and Neonatal Purpura Fulminans with a Purified Protein C Concentrate

1991 • 261 citations

Tissue Factor Pathway Inhibitor Gene Disruption Produces Intrauterine Lethality in Mice

1997 • 254 citations

A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state.

1998 • 253 citations

Anticoagulantly active heparin-like molecules from vascular tissue

1984 • 248 citations

The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity.

1991 • 229 citations

Activated protein C inhibits lipopolysaccharide‐induced nuclear translocation of nuclear factor κB (NF‐κB) and tumour necrosis factor α (TNF‐α) production in the THP‐1 monocytic cell line

2000 • 228 citations

Thrombin Activatable Fibrinolysis Inhibitor, a Potential Regulator of Vascular Inflammation

2003 • 222 citations

Complete antithrombin deficiency in mice results in embryonic lethality

2000 • 219 citations

Adhesive receptor Mac-1 coordinates the activation of factor X on stimulated cells of monocytic and myeloid differentiation: an alternative initiation of the coagulation protease cascade.

1988 • 215 citations

The Crystal Structure of the Endothelial Protein C Receptor and a Bound Phospholipid

2002 • 197 citations

Anti-Inflammatory, Antithrombotic, and Neuroprotective Effects of Activated Protein C in a Murine Model of Focal Ischemic Stroke

2001 • 191 citations

Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

2002 • 189 citations

Systemic Host Responses in Severe Sepsis Analyzed by Causative Microorganism and Treatment Effects of Drotrecogin Alfa (Activated)

2003 • 187 citations

Activated Protein C Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production by Inhibiting Activation of both Nuclear Factor-κB and Activator Protein-1 in Human Monocytes

2002 • 183 citations

Antithrombin III Prevents and Rapidly Reverses Leukocyte Recruitment in Ischemia/Reperfusion

1997 • 182 citations

Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice.

1998 • 181 citations

Expression and function of the endothelial protein C receptor in human neutrophils

2003 • 176 citations

Protein C Inhibitor Is a Potent Inhibitor of the Thrombin-Thrombomodulin Complex

1995 • 174 citations

Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli

2000 • 172 citations

CD40L-CD40 interactions regulate endothelial cell surface tissue factor and thrombomodulin expression

1998 • 157 citations

Antithrombin III inhibits nuclear factor κB activation in human monocytes and vascular endothelial cells

2002 • 150 citations

Alteration in glycosaminoglycan metabolism and surface charge on human umbilical vein endothelial cells induced by cytokines, endotoxin and neutrophils

1992 • 147 citations

Why do animal models (sometimes) fail to mimic human sepsis?

2004 • 145 citations

Intratracheal Administration of Activated Protein C Inhibits Bleomycin-induced Lung Fibrosis in the Mouse

2001 • 142 citations

Cell Mediated Events that Control Blood Coagulation and Vascular Injury

1993 • 138 citations

Complex-dependent inhibition of factor VIIa by antithrombin III and heparin.

1993 • 137 citations

Disruption of the Endothelial Cell Protein C Receptor Gene in Mice Causes Placental Thrombosis and Early Embryonic Lethality

2002 • 137 citations

Antithrombin III stimulates prostacyclin production by cultured aortic endothelial cells

1989 • 136 citations

Regulation of inflammatory responses by natural anticoagulants

2001 • 135 citations

Introduction: are natural anticoagulants candidates for modulating the inflammatory response to endotoxin?

2000 • 133 citations

Activated Protein C Prevents Endotoxin-Induced Hypotension in Rats by Inhibiting Excessive Production of Nitric Oxide

2001 • 122 citations

Thrombus formation: direct real-time observation and digital analysis of thrombus assembly in a living mouse by confocal and widefield intravital microscopy

2003 • 121 citations

Lipid antigen presentation in the immune system; lessons learned from CD 1 d knockout mice

1999 • 121 citations

Antithrombin inhibits lipopolysaccharide-induced tissue factor and interleukin-6 production by mononuclear cells, human umbilical vein endothelial cells, and whole blood

2001 • 119 citations

BINDING OF ACTIVATED PROTEIN C TO A SPECIFIC RECEPTOR ON HUMAN MONONUCLEAR PHAGOCYTES INHIBITS INTRACELLULAR CALCIUM SIGNALING AND MONOCYTE-DEPENDENT PROLIFERATIVE RESPONSES1,2

1995 • 119 citations

Transmembrane phospholipid distribution in blood cells: control mechanisms and pathophysiological significance.

1998 • 112 citations

The Influence of Capsulation and Lipooligosaccharide Structure on Neutrophil Adhesion Molecule Expression and Endothelial Injury by Neisseria meningitidis

1996 • 109 citations

Carboxypeptidase R is an inactivator of complement‐derived inflammatory peptides and an inhibitor of fibrinolysis

2001 • 99 citations

The fifth and sixth growth factor-like domains of thrombomodulin bind to the anion-binding exosite of thrombin and alter its specificity.

1992 • 97 citations

Elements of the Primary Structure of Thrombomodulin Required for Efficient Thrombin-activable Fibrinolysis Inhibitor Activation

2000 • 93 citations

Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: Up-regulation of poly(A) polymerase

1997 • 93 citations

A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation

2003 • 83 citations

Syndecan-4 as Antithrombin Receptor of Human Neutrophils

2001 • 82 citations

Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death

2004 • 81 citations

Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor‐dependent manner

2000 • 74 citations

Cytokines, platelet production and hemostasis

1997 • 73 citations

Activated protein C cleaves factor Va more efficiently on endothelium than on platelet surfaces

2002 • 51 citations

Structurally Homologous Ligand Binding of Integrin Mac-1 and Viral Glycoprotein C Receptors

1991 • 50 citations

The participation of leukocytes in coagulant reactions

2003 • 49 citations

Cytokines, platelet production and hemostasis

1997 • 14 citations