Phosphoinositide kinases

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

Control of p70 S6 kinase by kinase activity of FRAP in vivo

1995 • 717 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Purification and characterization of phosphoinositide 3-kinase from rat liver.

1990 • 640 citations

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

1994 • 620 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

ATP-dependent inositide phosphorylation required for Ca2+-activated secretion

1995 • 508 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1994 • 450 citations

Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.

1990 • 443 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.

1995 • 349 citations

A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids.

1995 • 349 citations

When is a lipid kinase not a lipid kinase? When it is a protein kinase

1995 • 315 citations

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

1995 • 311 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast.

1995 • 276 citations

The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.

1994 • 270 citations

Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.

1995 • 263 citations

Signal transduction and membrane traffic: The PITP/phosphoinositide connection

1995 • 261 citations

Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

1995 • 255 citations

Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.

1994 • 245 citations

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

1995 • 237 citations

Phosphatidylinositol 4-Kinase: Gene Structure and Requirement for Yeast Cell Viability

1993 • 211 citations

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.

1995 • 208 citations

Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes.

1995 • 202 citations

A novel gene, STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae.

1994 • 191 citations

Phosphatidylinositol 3-Kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Trafficking

1995 • 165 citations

Expression and characterization of an inositol 1,4,5-trisphosphate binding domain of phosphatidylinositol-specific phospholipase C-delta 1.

1994 • 141 citations

The Sequence of Phosphatidylinositol-4-phosphate 5-Kinase Defines a Novel Family of Lipid Kinases

1995 • 141 citations

Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells

1994 • 131 citations

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

1994 • 130 citations

Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways

1995 • 108 citations

D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes.

1994 • 107 citations

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.

1993 • 98 citations

Cloning and characterization of a human phosphatidylinositol 4-kinase.

1994 • 95 citations

The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity

1995 • 85 citations

Phosphatidylinositol( , , ) -Trisphosphate Stimulates Phosphorylation of Pleckstrin in Human Platelets

1995 • 56 citations

Protein regulation by phosphatidylinositol lipids

1995 • 53 citations