Blood Vessel Formation: What Is Its Molecular Basis?

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Role of tissue factor in embryonic blood vessel development

1996 • 693 citations

Endothelial receptor tyrosine kinases involved in angiogenesis.

1995 • 537 citations

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

1992 • 410 citations

Induction of vasculogenesis and hematopoiesis in vitro

1992 • 345 citations

Reduction of smooth muscle hyperplasia in vein grafts in athymic rats.

1991 • 17 citations