Regulation of vascular endothelial barrier function

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Pharmacology of bradykinin and related kinins.

1983 • 1,674 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION

1990 • 1,293 citations

Flow Effects on Prostacyclin Production by Cultured Human Endothelial Cells

1985 • 1,237 citations

Transferrin receptor on endothelium of brain capillaries

1984 • 1,008 citations

Cytoskeleton—Plasma Membrane Interactions

1992 • 792 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

A novel endothelial-specific membrane protein is a marker of cell-cell contacts.

1992 • 637 citations

Mechanical stress mechanisms and the cell. An endothelial paradigm.

1993 • 636 citations

STRUCTURE AND FUNCTION OF SIGNAL-TRANSDUCING GTP-BINDING PROTEINS

1991 • 630 citations

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

1988 • 610 citations

Distribution, properties, and functional characteristics of three classes of histamine receptor.

1990 • 579 citations

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

Structure, function, and regulation of cellular tight junctions

1992 • 517 citations

A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide.

1986 • 510 citations

Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells.

1986 • 491 citations

Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function.

1992 • 424 citations

Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: receptor-mediated transcytosis.

1986 • 375 citations

Flow-dependent, endothelium-mediated dilation of epicardial coronary arteries in conscious dogs: effects of cyclooxygenase inhibition.

1984 • 367 citations

Function follows form: generation of intracellular signals by cell deformation

1991 • 345 citations

Intestinal absorptive cell tight junctions are linked to cytoskeleton

1987 • 343 citations

CONTROL OF NONMUSCLE MYOSINS BY PHOSPHORYLATION

1992 • 338 citations

The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.

1992 • 312 citations

Thrombin‐induced increase in albumin permeability across the endothelium

1986 • 307 citations

A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells.

1984 • 303 citations

Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel

1989 • 299 citations

The role of integrins in the maintenance of endothelial monolayer integrity.

1991 • 290 citations

Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers.

1986 • 289 citations

Transcytosis of albumin in capillary endothelium.

1987 • 269 citations

Functional heterogeneity of vascular endothelial cells

1987 • 265 citations

Molecular sieving characteristics of the cultured endothelial monolayer

1987 • 254 citations

Changes in cytosolic Ca2+ associated with von Willebrand factor release in human endothelial cells exposed to histamine. Study of microcarrier cell monolayers using the fluorescent probe indo-1.

1987 • 225 citations

Characterization of the Bradykinin-stimulated Calcium Influx Pathway of Cultured vascular Endothelial Cells

1989 • 224 citations

Shear stress increases inositol trisphosphate levels in human endothelial cells

1990 • 215 citations

Vinculin, a cytoskeletal substrate of protein kinase C.

1983 • 215 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

Reversible oxidant-induced increases in albumin transfer across cultured endothelium: alterations in cell shape and calcium homeostasis

1985 • 210 citations

Response of cultured endothelial cells to steady flow

1984 • 209 citations

Expression of organ-specific antigens on capillary endothelial cells

1985 • 200 citations

Cytoskeletal and morphologic impact of cellular oxidant injury.

1986 • 190 citations

Identification and characterization of cell-substratum adhesion receptors on cultured human endothelial cells.

1989 • 186 citations

Role of reactive oxygen species in reperfusion injury of the rabbit lung.

1989 • 180 citations

Epidermal growth factor activates calcium channels by phospholipase A25-lipoxygenase-mediated leukotriene C4 production

1992 • 179 citations

Structural basis of permeability in sequential segments of the microvasculature of the diaphragm

1978 • 175 citations

Endothelial albumin permeability is shear dependent, time dependent, and reversible

1991 • 166 citations

Protein kinase C phosphorylates caldesmon₇₇ and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1992 • 163 citations

Fibronectin and F-actin redistribution in cultured endothelial cells exposed to shear stress.

1985 • 159 citations

Reactive oxygen injury to cultured pulmonary artery endothelial cells: Mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance

1991 • 156 citations

Differential expression of cell surface glycoproteins on various organ‐derived microvascular endothelia and endothelial cell cultures

1988 • 155 citations

Histamine receptors of the microvascular endothelium revealed in situ with a histamine-ferritin conjugate: characteristic high-affinity binding sites in venules.

1982 • 153 citations

Fibrinogen induces adhesion, spreading, and microfilament organization of human endothelial cells in vitro.

1987 • 151 citations

Albumin interacts specifically with a 60-kDa microvascular endothelial glycoprotein.

1988 • 146 citations

Histamine and interstitial Pulmonary Edema in the Dog

1971 • 144 citations

Interstitial diffusion of macromolecules in the rat mesentery

1979 • 144 citations

Cytochalasin B enhancement of the diacylglycerol response in formyl peptide-stimulated neutrophils.

1986 • 133 citations

Translocation of protein kinase C isozymes in thrombin-stimulated human platelets. Correlation with 1,2-diacylglycerol levels.

1992 • 130 citations

Permeability of human endothelial monolayers: effect of vasoactive agonists and cAMP

1989 • 128 citations

The three-dimensional organization of plasmalemmal vesicular profiles in the endothelium of rat heart capillaries

1983 • 122 citations

Activation of protein kinase C pathway contributes to hydrogen peroxide-induced increase in endothelial permeability.

1992 • 122 citations

Endothelial cell monolayer integrity. I. Characterization of dense peripheral band of microfilaments.

1986 • 119 citations

The effect of altering the external calcium concentration and a calcium channel blocker, verapamil, on microvascular leaky sites and dextran clearance in the hamster cheek pouch

1984 • 116 citations

Peptide inhibitors of fibronectin, laminin, and other adhesion molecules: Unique and shared features

1987 • 114 citations

Increased permeability of microcarrier-cultured endothelial monolayers in response to histamine and thrombin. A model for the in vitro study of increased vasopermeability.

1986 • 113 citations

Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation.

1992 • 107 citations

Leukocyte interleukins induce cultured endothelial cells to produce a highly organized, glycosaminoglycan-rich pericellular matrix.

1984 • 102 citations

Phalloidin enhances endothelial barrier function and reduces inflammatory permeability in vitro

1988 • 102 citations

Exogenous oxidants initiate hydrolysis of endothelial cell inositol phospholipids

1988 • 100 citations

Role of protein kinase C in bradykinin-induced increases in microvascular permeability.

1991 • 99 citations

Antagonists of B ₂ bradykinin receptors

1989 • 97 citations

Identification and cloning of two species of cadherins in bovine endothelial cells.

1990 • 96 citations

A CD44-like endothelial cell transmembrane glycoprotein (GP116) interacts with extracellular matrix and ankyrin.

1992 • 96 citations

Shear stress induced membrane currents and calcium transients in human vascular endothelial cells

1992 • 94 citations

Human microvascular endothelial cells express integrin‐related complexes that mediate adhesion to the extracellular matrix

1989 • 93 citations

An N‐cadherin–like protein contributes to solute barrier maintenance in cultured endothelium

1993 • 92 citations

A 14 amino acid peptide derived from the amino terminus of the cleaved thrombin receptor elevates intracellular calcium and stimulates prostacyclin production in human endothelial cells

1991 • 90 citations

Circulating plasma kinin in patients with bronchial asthma

1967 • 89 citations

Guanine nucleotide‐dependent, pertussis toxin‐insensitive regulation of phosphoinositide turnover by bradykinin in bovine pulmonary artery endothelial cells

1989 • 87 citations

Nature of Thrombin-induced Sustained Increase in Cytosolic Calcium Concentration in Cultured Endothelial Cells

1989 • 85 citations

The Normal Lung: The Basis for Diagnosis and Treatment of Pulmonary Disease

1985 • 84 citations

Towards selective pharmacological modulation of protein kinase C – opportunities for the development of novel antineoplastic agents

1992 • 81 citations

Oxygen-dependent reperfusion injury in the isolated rat lung

1992 • 81 citations

Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin

1989 • 80 citations

Hydrogen peroxide alters the physical state and function of the plasma membrane of pulmonary artery endothelial cells

1991 • 78 citations

Caldesmon: A common actin‐linked regulatory protein in the smooth muscle and nonmuscle contractile system

1988 • 77 citations

DNA Strand Break Formation Following Exposure of Bovine Pulmonary Artery and Aortic Endothelial Cells to Reactive Oxygen Products

1991 • 75 citations

Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization.

1993 • 75 citations

Differential regulation of phosphoinositide and phosphatidylcholine hydrolysis by protein kinase C-beta 1 overexpression. Effects on stimulation by alpha-thrombin, guanosine 5'-O-(thiotriphosphate), and calcium.

1992 • 72 citations

Inflammatory agonists that increase microvascular permeability in vivo stimulate cultured pulmonary microvessel endothelial cell contraction

1990 • 71 citations

Mechanisms of extracellular reactive oxygen species injury to the pulmonary microvasculature

1992 • 71 citations

A protein kinase C inhibitory activity is present in rat brain homogenate

1984 • 70 citations

Time course of thrombin-induced increase in endothelial permeability: relationship to Ca2+i and inositol polyphosphates

1992 • 66 citations

Monohydroxyeicosatetraenoic acids (5-HETE and 15-HETE) induce pulmonary vasoconstriction and edema.

1988 • 65 citations

Endothelial Cells as A Source of Oxygen-Free Radicals An Esr Study

1990 • 65 citations

Aortic endothelial cell during regeneration. Remodeling of cell junctions, stress fibers, and stress fiber-membrane attachment domains.

1985 • 63 citations

Superoxide production by human umbilical vein endothelial cells in an anoxia-reoxygenation model

1989 • 61 citations

Tumor promoter-induced disruption of junctional complexes in cultured epithelial cells is followed by the inhibition of cytokeratin and desmoplakin synthesis

1986 • 60 citations

Agonist control of G-protein levels

1991 • 59 citations

Role of peptidases in bradykinin-induced increase in vascular permeability in vivo.

1992 • 57 citations

Effects of diacylglycerols on LLC‐PK₁ renal epithelia: Similarity to phorbol ester tumor promoters

1988 • 54 citations

Influence of extracellular matrix in tumor necrosis factor-induced increase in endothelial permeability

1992 • 50 citations

Leakage of macromolecules from the tracheobronchial microcirculation.

1987 • 49 citations

Synthetic peptide GRGDS induces dissociation of alpha-actinin and vinculin from the sites of focal contacts.

1988 • 48 citations

Oxidant stress and adult respiratory distress syndrome.

1990 • 46 citations

Pulmonary microvascular endothelial cells constitutively release xanthine oxidase

1992 • 44 citations

Calcium dependence of histamine-induced increases in capillary permeability in isolated perfused rat hindquarters

1986 • 43 citations

The effect of histamine on cultured endothelial cells A study of the mechanism of increased vascular permeability

1992 • 40 citations

Endogenous inhibitor of protein kinase C: association with human peripheral blood neutrophils but not with specific granule-deficient neutrophils or cytoplasts.

1986 • 38 citations

Calcium signaling in endothelia: cellular heterogeneity and receptor internalization

1992 • 34 citations

GTP_γS Increases Thrombin-mediated Inositol Trisphosphate Accumulation in Permeabilized Human Endothelial Cells

1989 • 34 citations

Effects of thrombin on the integrity of monolayers of cultured human endothelial cells

1982 • 32 citations

How Are Macromolecules Transported Across the Capillary Wall?

1987 • 29 citations

Selectivity of the endothelial monolayer: Effects of increased permeability

1988 • 29 citations

Protective effects of calcium channel blockers on hydrogen peroxide induced increases in endothelial permeability

1990 • 24 citations

Bradykinin-induced increase in pulmonary vascular permeability in hypoxic sheep

1982 • 24 citations

Action and metabolism of bradykinin in dog lung.

1973 • 23 citations

H2 receptor-mediated responses of aortic endothelial cells to histamine

1992 • 21 citations

Control of cell function by reversible protein phosphorylation.

1986 • 18 citations

Movement of receptors and ligands through the endocytic apparatus in alveolar macrophages

1990 • 13 citations

Histaminergic H1-receptors in smooth muscle and endothelium of bovine thoracic aorta

1989 • 13 citations

Molecular distribution within a 1% collagen gel column

1979 • 6 citations