The Catalytic Activity of the Src Family Kinases Is Required to Disrupt Cadherin-dependent Cell–Cell Contacts

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

E-cadherin germline mutations in familial gastric cancer

1998 • 1,629 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Cadherins in cancer: implications for invasion and metastasis

1993 • 939 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

1996 • 858 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous cell carcinomas.

1981 • 743 citations

Evidence for the identity of human scatter factor and human hepatocyte growth factor.

1991 • 651 citations

The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn

1998 • 566 citations

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.

1992 • 519 citations

Activating SRC mutation in a subset of advanced human colon cancers

1999 • 473 citations

Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

1994 • 421 citations

p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.

1993 • 421 citations

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

1994 • 405 citations

Expression of immunoreactive E-cadherin adhesion molecules in human cancers.

1991 • 379 citations

Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src).

1981 • 363 citations

Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.

1989 • 349 citations

Expression of E- and P-cadherin in gastric carcinomas.

1991 • 345 citations

The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells.

1993 • 338 citations

The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.

1992 • 312 citations

Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated.

1991 • 310 citations

Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.

1995 • 304 citations

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

1998 • 290 citations

Functional Domains of α-Catenin Required for the Strong State of Cadherin-based Cell Adhesion

1999 • 257 citations

Tyrosine Phosphorylation and Src Family Kinases Control Keratinocyte Cell–Cell Adhesion

1998 • 254 citations

Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

1994 • 253 citations

Cytoskeleton—membrane interactions

1996 • 231 citations

Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin.

1996 • 221 citations

V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift.

1995 • 216 citations

Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins.

1996 • 176 citations

Human keratinocytes are a major source of cutaneous platelet-derived growth factor.

1993 • 149 citations

Src and Ras are involved in separate pathways in epithelial cell scattering

1997 • 141 citations

pp60(c-src) is required for cell locomotion regulated by the hyaluronanreceptor RHAMM.

1996 • 140 citations

Regulation of Complexed and Free Catenin Pools by Distinct Mechanisms

1997 • 138 citations

Human Keratinocyte Locomotion: The Effect of Selected Cytokines

1992 • 99 citations

Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas.

1993 • 97 citations

Transformation-Specific Tyrosine Phosphorylation of a Novel Cellular Protein in Chicken Cells Expressing Oncogenic Variants of the Avian Cellular src Gene

1989 • 95 citations

Comparative Study of Hepatocyte Growth Factor/Scatter Factor and Keratinocyte Growth Factor Effects on Human Keratinocytes

1995 • 80 citations

Regulation of cell-cell contacts in developing Drosophila eyes by Dsrc41, a new, close relative of vertebrate c-src.

1996 • 79 citations

Cytoskeletal involvement in the modulation of cell-cell junctions by the protein kinase inhibitor H-7

1994 • 79 citations

The Radiosensitivity of Cultured Human and Mouse Keratinocytes

1986 • 25 citations

Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis.

1991 • 18 citations