Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

ERM proteins and merlin: integrators at the cell cortex

2002 • 1,301 citations

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

2002 • 1,225 citations

Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association

1998 • 849 citations

Rho family proteins: coordinating cell responses

2001 • 763 citations

Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes

2002 • 707 citations

Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils

2003 • 690 citations

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor

1999 • 673 citations

Leukocyte polarization in cell migration and immune interactions

1999 • 622 citations

Rho GTPase-activating proteins in cell regulation

2002 • 608 citations

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

1996 • 601 citations

Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2

1998 • 592 citations

Identification of EBP50: A PDZ-containing Phosphoprotein that Associates with Members of the Ezrin-Radixin-Moesin Family

1997 • 582 citations

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

1999 • 568 citations

Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo

1999 • 559 citations

Regulation of Cell Polarity and Protrusion Formation by Targeting RhoA for Degradation

2003 • 532 citations

RhoA is required for monocyte tail retraction during transendothelial migration

2001 • 498 citations

Rho Guanine Dissociation Inhibitors

1999 • 487 citations

An Apical PDZ Protein Anchors the Cystic Fibrosis Transmembrane Conductance Regulator to the Cytoskeleton

1998 • 472 citations

Cortical Actin Organization: Lessons from ERM (Ezrin/Radixin/Moesin) Proteins

1999 • 464 citations

Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells

1993 • 426 citations

Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein

1997 • 424 citations

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site.

1995 • 422 citations

Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1

2002 • 421 citations

Direct Binding of the Na–H Exchanger NHE1 to ERM Proteins Regulates the Cortical Cytoskeleton and Cell Shape Independently of H+ Translocation

2000 • 407 citations

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

2000 • 380 citations

Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin

2004 • 362 citations

Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro.

1996 • 353 citations

Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members.

1994 • 347 citations

Current molecular models for NADPH oxidase regulation by Rac GTPase

2002 • 335 citations

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI

2002 • 326 citations

Association of Ezrin with Intercellular Adhesion Molecule-1 and -2 (ICAM-1 and ICAM-2)

1998 • 325 citations

Ezrin, a plasma membrane–microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway

1999 • 319 citations

T-cell integrins: more than just sticking points

2003 • 312 citations

Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes

2002 • 305 citations

RhoA and ROCK Promote Migration by Limiting Membrane Protrusions

2003 • 304 citations

Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins

1997 • 303 citations

Molecular characterization of phagosomes.

1994 • 287 citations

Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility

2001 • 287 citations

Morphogenic Effects of Ezrin Require a Phosphorylation-Induced Transition from Oligomers to Monomers at the Plasma Membrane

2000 • 274 citations

Exclusion of CD43 from the Immunological Synapse Is Mediated by Phosphorylation-Regulated Relocation of the Cytoskeletal Adaptor Moesin

2001 • 270 citations

ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation

2004 • 262 citations

Protein Kinase C-α Signals Rho-Guanine Nucleotide Dissociation Inhibitor Phosphorylation and Rho Activation and Regulates the Endothelial Cell Barrier Function

2001 • 253 citations

ICAM-1 Signaling Pathways Associated with Rho Activation in Microvascular Brain Endothelial Cells

1998 • 252 citations

ERM-Dependent Movement of CD43 Defines a Novel Protein Complex Distal to the Immunological Synapse

2001 • 247 citations

Rho Family Proteins Modulate Rapid Apoptosis Induced by Cytotoxic T Lymphocytes and Fas

2000 • 244 citations

Rho-dependent and -independent activation mechanisms of ezrin/radixin/moesin proteins: an essential role for polyphosphoinositides in vivo

2002 • 240 citations

P-selectin Glycoprotein Ligand-1 Mediates L-Selectin–dependent Leukocyte Rolling in Venules

2003 • 240 citations

Moesin Interacts with the Cytoplasmic Region of Intercellular Adhesion Molecule-3 and Is Redistributed to the Uropod of T Lymphocytes during Cell Polarization

1997 • 238 citations

Mutagenesis of the Phosphatidylinositol 4,5-Bisphosphate (Pip2) Binding Site in the Nh2-Terminal Domain of Ezrin Correlates with Its Altered Cellular Distribution

2000 • 234 citations

ICAM-2 redistributed by ezrin as a target for killer cells

1996 • 233 citations

Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly

2000 • 230 citations

Phosphorylation of Moesin by Rho-associated Kinase (Rho-kinase) Plays a Crucial Role in the Formation of Microvilli-like Structures

1998 • 229 citations

Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes

1999 • 229 citations

Calpain Cleavage Promotes Talin Binding to the β3Integrin Cytoplasmic Domain

2001 • 219 citations

CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

2000 • 217 citations

Protein Kinase C-θ Phosphorylation of Moesin in the Actin-binding Sequence

1998 • 213 citations

ITAM-Based Interaction of ERM Proteins with Syk Mediates Signaling by the Leukocyte Adhesion Receptor PSGL-1

2002 • 212 citations

Association of the Myosin-binding Subunit of Myosin Phosphatase and Moesin: Dual Regulation of Moesin Phosphorylation by Rho-associated Kinase and Myosin Phosphatase

1998 • 210 citations

Direct Involvement of Ezrin/Radixin/Moesin (ERM)-binding Membrane Proteins in the Organization of Microvilli in Collaboration with Activated ERM Proteins

1999 • 209 citations

Phosphorylation of Threonine 558 in the Carboxyl-terminal Actin-binding Domain of Moesin by Thrombin Activation of Human Platelets

1995 • 205 citations

Merlin and ERM proteins: unappreciated roles in cancer development?

2003 • 191 citations

The Membrane-Microfilament Linker Ezrin Is Involved in the Formation of the Immunological Synapse and in T Cell Activation

2001 • 189 citations

RhoA-Dependent Phosphorylation and Relocalization of ERM Proteins into Apical Membrane/Actin Protrusions in Fibroblasts

1998 • 183 citations

Lysophospholipids and their G protein-coupled receptors in inflammation and immunity

2002 • 179 citations

Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes

2000 • 175 citations

Normal Development of Mice and Unimpaired Cell Adhesion/Cell Motility/Actin-based Cytoskeleton without Compensatory Up-regulation of Ezrin or Radixin in Moesin Gene Knockout

1999 • 170 citations

Virginiae Butanolide Binding Protein from Streptomyces virginiae

1995 • 169 citations

GTPases and T cell activation

2003 • 168 citations

Spatial and Temporal Analysis of Rac Activation during Live Neutrophil Chemotaxis

2002 • 167 citations

ERM (Ezrin/Radixin/Moesin)-based Molecular Mechanism of Microvillar Breakdown at an Early Stage of Apoptosis

1997 • 164 citations

Cutting Edge: Negative Regulation of Immune Synapse Formation by Anchoring Lipid Raft to Cytoskeleton Through Cbp-EBP50-ERM Assembly

2002 • 160 citations

Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex

2003 • 158 citations

Vav Family Proteins Couple to Diverse Cell Surface Receptors

2000 • 148 citations

Subcellular Localization of Moesin in Dynamic Filopodia, Retraction Fibers, and Other Structures Involved in Substrate Exploration, Attachment, and Cell-Cell Contacts

1995 • 147 citations

Chemokine stimulation of human peripheral blood T lymphocytes induces rapid dephosphorylation of ERM proteins, which facilitates loss of microvilli and polarization

2003 • 144 citations

The role of Rho GTPases and associated kinases in regulating neurite outgrowth

2002 • 139 citations

P-glycoprotein–actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin

2002 • 135 citations

Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl

1998 • 120 citations

Activation of the PKB/AKT Pathway by ICAM-2

2002 • 119 citations

Phosphorylation of ERM proteins at filopodia induced by Cdc42

2000 • 119 citations

Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain

1999 • 119 citations

A novel role for RhoGDI as an inhibitor of GAP proteins.

1993 • 117 citations

Colocalization of F-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophages.

1990 • 112 citations

Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrin

1999 • 108 citations

Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins.

1993 • 107 citations

The Cytoplasmic Tail of L-selectin Interacts with Members of the Ezrin-Radixin-Moesin (ERM) Family of Proteins

2002 • 103 citations

Cytoplasmic anchorage of L-selectin controls leukocyte capture and rolling by increasing the mechanical stability of the selectin tether

2001 • 102 citations

Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin

2002 • 99 citations

The distal pole complex: a novel membrane domain distal to the immunological synapse

2002 • 97 citations

Migration of leukocytes through the vessel wall and beyond

2003 • 96 citations

Conformational Activation of Radixin by G13 Protein α Subunit

2000 • 78 citations

Rho regulates association of both the ERM family and vinculin with the plasma membrane in MDCK cells

1997 • 75 citations

Radixin Is a Component of Hepatocyte Microvilli in Situ

1994 • 74 citations

The NADPH Oxidase Components p47phox and p40phox Bind to Moesin through Their PX Domain

2001 • 74 citations

Leukocyte uropod formation and membrane/cytoskeleton linkage in immune interactions

2003 • 74 citations

The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain

2004 • 72 citations

A Novel Serine-rich Motif in the Intercellular Adhesion Molecule 3 Is Critical for Its Ezrin/Radixin/Moesin-directed Subcellular Targeting

2002 • 71 citations

Increased Ezrin Expression and Activation by CDK5 Coincident with Acquisition of the Senescent Phenotype

2003 • 70 citations

Cytoskeletal remodeling in lymphocyte activation

2003 • 69 citations

Differential expression of the microspike-associated protein moesin in human tissues.

1995 • 64 citations

Spatiotemporal Regulation of Moesin Phosphorylation and Rear Release by Rho and Serine/Threonine Phosphatase during Neutrophil Migration

2002 • 63 citations

L-Selectin Regulates Actin Polymerisation via Activation of the Small G-Protein Rac2

1997 • 60 citations

Identification of a novel Ezrin‐binding site in syndecan‐2 cytoplasmic domain

2003 • 60 citations

Identification and Relevance of the CD95-binding Domain in the N-terminal Region of Ezrin

2004 • 57 citations

L‐selectin activates JNK via src‐like tyrosine kinases and the small G‐protein Rac

1997 • 57 citations

Imaging of T‐cell interactions with antigen presenting cells in culture and in intact lymphoid tissue

2002 • 56 citations

Protein Phosphatase 2C Inactivates F-actin Binding of Human Platelet Moesin

1999 • 50 citations

Ezrin is a substrate for Lck in T cells

2002 • 42 citations

Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation

2001 • 40 citations

[4] Purification of the intestnal microvillus cytoskeletal proteins villin, fimbrin, and ezrin

1986 • 36 citations

Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation

1996 • 34 citations

Differential expression and distribution of ezrin, radixin and moesin in human natural killer cells

2002 • 31 citations

Ezrin and moesin co-localise with ICAM-1 in brain endothelial cells but are not directly associated

2002 • 25 citations

A role for moesin in polarity

2003 • 19 citations

Crystallization and preliminary crystallographic studies of RhoGDI in complex with the radixin FERM domain

2001 • 13 citations

Increased Ezrin Expression and Activation by CDK5 Coincident with Acquisition of the Senescent Phenotype

2003 • 6 citations