Differential regulation of diverse physiological responses to VEGF in pulmonary endothelial cells

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

1995 • 1,280 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

Micromotion of mammalian cells measured electrically.

1991 • 813 citations

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death‐dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

2001 • 776 citations

Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells

1998 • 695 citations

Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

1998 • 638 citations

Analysis of Biological Effects and Signaling Properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2)

2001 • 625 citations

Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site

1997 • 574 citations

Vascular Endothelial Growth Factor, a Potent and Selective Angiogenic Agent

1996 • 570 citations

VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells

1999 • 563 citations

Akt Mediates Cytoprotection of Endothelial Cells by Vascular Endothelial Growth Factor in an Anchorage-dependent Manner

1999 • 557 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Vascular Endothelial Growth Factor Signals Endothelial Cell Production of Nitric Oxide and Prostacyclin through Flk-1/KDR Activation of c-Src

1999 • 481 citations

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

1995 • 480 citations

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia

1999 • 468 citations

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins

1995 • 466 citations

Nitric Oxide Is an Upstream Signal of Vascular Endothelial Growth Factor-induced Extracellular Signal-regulated Kinase½ Activation in Postcapillary Endothelium

1998 • 436 citations

The Vascular Endothelial Growth Factor Receptor KDR Activates Multiple Signal Transduction Pathways in Porcine Aortic Endothelial Cells

1997 • 436 citations

New Insights into the Control of MAP Kinase Pathways

1999 • 431 citations

Inhibition of Extracellular Signal–Regulated Kinase Enhances Ischemia/Reoxygenation–Induced Apoptosis in Cultured Cardiac Myocytes and Exaggerates Reperfusion Injury in Isolated Perfused Heart

2000 • 419 citations

Vascular Endothelial Growth Factor–Stimulated Actin Reorganization and Migration of Endothelial Cells Is Regulated via the Serine/Threonine Kinase Akt

2000 • 413 citations

Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues

1993 • 369 citations

VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis

1996 • 342 citations

Vascular Permeability Factor/Vascular Endothelial Cell Growth Factor-mediated Permeability Occurs through Disorganization of Endothelial Junctional Proteins

1998 • 320 citations

Stimulation of “Stress-regulated” Mitogen-activated Protein Kinases (Stress-activated Protein Kinases/c-Jun N-terminal Kinases and p38-Mitogen-activated Protein Kinases) in Perfused Rat Hearts by Oxidative and Other Stresses

1998 • 320 citations

Vascular Endothelial Growth Factor (VEGF)-driven Actin-based Motility Is Mediated by VEGFR2 and Requires Concerted Activation of Stress-activated Protein Kinase 2 (SAPK2/p38) and Geldanamycin-sensitive Phosphorylation of Focal Adhesion Kinase

2000 • 314 citations

Three-Dimensional Reconstruction of Pulmonary Arteries in Plexiform Pulmonary Hypertension Using Cell-Specific Markers

1999 • 297 citations

Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells

2000 • 291 citations

Multiple Developmental Roles of VEGF Suggested by a LacZ-Tagged Allele

1999 • 284 citations

VEGF and flt

1996 • 276 citations

A Recombinant Mutant Vascular Endothelial Growth Factor-C that Has Lost Vascular Endothelial Growth Factor Receptor-2 Binding, Activation, and Vascular Permeability Activities

1998 • 252 citations

Signal perception and transduction: the role of protein kinases

1999 • 222 citations

SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.

2001 • 217 citations

PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits

1999 • 217 citations

Extracellular Signal-regulated Protein Kinase/Jun Kinase Cross-talk Underlies Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation

1998 • 216 citations

Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart

1994 • 215 citations

Vascular Endothelial Growth Factor Up-regulates ICAM-1 Expression via the Phosphatidylinositol 3 OH-kinase/AKT/Nitric Oxide Pathway and Modulates Migration of Brain Microvascular Endothelial Cells

2000 • 214 citations

VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo

1998 • 195 citations

VEGF induces hyperpermeability by a direct action on endothelial cells

1998 • 178 citations

Induction of Endothelial Cell Chemotaxis by Sphingosine 1-Phosphate and Stabilization of Endothelial Monolayer Barrier Function by Lysophosphatidic Acid, Potential Mediators of Hematopoietic Angiogenesis

1999 • 159 citations

Protein Kinase G Mediates Vascular Endothelial Growth Factor-induced Raf-1 Activation and Proliferation in Human Endothelial Cells

1998 • 156 citations

Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability

1999 • 147 citations

Heart and lung VEGF mRNA expression in rats with monocrotaline- or hypoxia-induced pulmonary hypertension

1998 • 142 citations

Vascular endothelial growth factor is a survival factor for renal tubular epithelial cells

2000 • 131 citations

Effect of Vascular Endothelial Growth Factor on Cultured Endothelial Cell Monolayer Transport Properties

2000 • 126 citations

Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro

1996 • 117 citations

A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability

2001 • 105 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor Inhibits Anchorage-Disruption-Induced Apoptosis in Microvessel Endothelial Cells by Inducing Scaffold Formation

1997 • 98 citations

Mechanisms of ionomycin-induced endothelial cell barrier dysfunction

1997 • 98 citations

Signal relays in the VEGF system

1999 • 98 citations

Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium.

1998 • 94 citations

Role of Ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction

2000 • 93 citations

Angiogenesis in bronchial circulatory system after unilateral pulmonary artery obstruction

1997 • 87 citations

Signal relays in the VEGF system

1999 • 82 citations

Vascular permeability and epithelial transport effects on lung edema formation in ischemia and reperfusion

1994 • 77 citations

Diperoxovanadate alters endothelial cell focal contacts and barrier function: role of tyrosine phosphorylation

2000 • 76 citations

Enhanced expression of vascular endothelial growth factor in pulmonary plexogenic arteriopathy due to congenital heart disease

2000 • 73 citations

VEGF stimulates tyrosine phosphorylation of β-catenin and small-pore endothelial barrier dysfunction

1999 • 71 citations

Serum Levels of Vascular Endothelial Growth Factor in Patients with Acute Myocardial Infarction Undergoing Reperfusion Therapy

1997 • 70 citations

Activation of Mitogen-Activated Protein Kinases in Human Heart During Cardiopulmonary Bypass

2000 • 69 citations

Oxygen-Independent Upregulation of Vascular Endothelial Growth Factor and Vascular Barrier Dysfunction during Ventilated Pulmonary Ischemia in Isolated Ferret Lungs

2000 • 61 citations

Increased resistance in postobstructive pulmonary vasculopathy: structure-function relationships

1991 • 61 citations

Phosphorylation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase after transient forebrain ischemia in mice

2000 • 59 citations

Role of Ca²⁺/calmodulin-dependent phosphatase 2B in thrombin-induced endothelial cell contractile responses

1998 • 44 citations

Transient Ultrastructural Injury and Repair of Pulmonary Capillaries in Transplanted Rat Lung: Effect of Preservation and Reperfusion

1992 • 32 citations

Separate effects of ischemia and reperfusion on vascular permeability in ventilated ferret lungs

1992 • 28 citations

ZK7, a novel zinc finger gene, is induced by vascular endothelial growth factor and inhibits apoptotic death in hematopoietic cells.

2000 • 26 citations

VEGF, fetal liver kinase-1, and permeability increase during unilateral lung ischemia

2000 • 25 citations

Effects of oxygen tension and glucose concentration on ischemic injury in ventilated ferret lungs

1993 • 19 citations