Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Rac Downregulates Rho Activity

1999 • 840 citations

Bidirectional signaling between the cytoskeleton and integrins

1999 • 765 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.

1995 • 324 citations

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

1998 • 290 citations

Selective regulation of integrin–cytoskeleton interactions by the tyrosine kinase Src

1999 • 257 citations

c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation.

1995 • 256 citations

rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo.

1993 • 236 citations

Activation of β1 Integrin Signaling Stimulates Tyrosine Phosphorylation of p190 and Membrane-protrusive Activities at Invadopodia

1998 • 204 citations

Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility.

1994 • 199 citations

Induction of Cell Scattering by Expression of β1 Integrins in β1-Deficient Epithelial Cells Requires Activation of Members of the Rho Family of Gtpases and Downregulation of Cadherin and Catenin Function

1999 • 150 citations

Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation

1999 • 148 citations

pp60(c-src) is required for cell locomotion regulated by the hyaluronanreceptor RHAMM.

1996 • 140 citations

Requirement for Rho in Integrin Signalling

1997 • 127 citations

The Function of the p190 Rho GTPase-activating Protein Is Controlled by Its N-terminal GTP Binding Domain

1998 • 83 citations

Src tyrosine kinase activity down-regulates Rho-dependent responses during Shigella entry into epithelial cells and stress fibre formation

2000 • 59 citations

Differential activation of focal adhesion kinase, Rho and Rac by the ninth and tenth FIII domains of fibronectin

1999 • 26 citations