The Effect of Lower Intraabdominal Pressure on Syndecan-1, sVEGF-R2, Occludin, KIM-1, and IL-6 on Living Donor Laparoscopic Nephrectomy

NCT03219398

NAINTERVENTIONAL

Indonesia University

44 participants

Started 2017-08-01 · Completed 2018-12-01

Status: Completed (as of 12-23-2025)

Conditions

Healthy

Interventions

PROCEDURE: Pneumoperitoneum pressure

Linked Papers (from SciSciNet-V2)

Total Papers112

Background

17

Result

0

Derived

0

Unknown

95

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

This study aimed to evaluate the increase of intraabdominal pressure 12- 14 mmHg caused by pneumoperitoneum resulted from carbon dioxide (CO2) insufflation induce glycocalyx endothelial injury that cause kidney tubular injury on live donor patient that undergo laparoscopic nephrectomy surgery, and decreasing the intraabdominal pressure to 8-10 mmHg during surgery is expected to reduce the injury.

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Background Papers34

Cellular pathophysiology of ischemic acute kidney injury

1,759 citations

Cellular pathophysiology of ischemic acute kidney injury

1,759 citations

The endothelial glycocalyx: composition, functions, and visualization

1,672 citations

The endothelial glycocalyx: composition, functions, and visualization

1,672 citations

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies

Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies

Glomerular endothelial cell injury and cross talk in diabetic kidney disease

Glomerular endothelial cell injury and cross talk in diabetic kidney disease

P-selectin must extend a sufficient length from the plasma membrane to mediate rolling of neutrophils.

P-selectin must extend a sufficient length from the plasma membrane to mediate rolling of neutrophils.

A role for the epidermal growth factor-like domain of P-selectin in ligand recognition and cell adhesion

A role for the epidermal growth factor-like domain of P-selectin in ligand recognition and cell adhesion

Association of Endothelial Glycocalyx and Tight and Adherens Junctions with Severity of Plasma Leakage in Dengue Infection

Association of Endothelial Glycocalyx and Tight and Adherens Junctions with Severity of Plasma Leakage in Dengue Infection

Basics of kidney biopsy: A nephrologist′s perspective

Basics of kidney biopsy: A nephrologist′s perspective

Soluble VEGFR‐2: an antilymphangiogenic variant of VEGF receptors

Soluble VEGFR‐2: an antilymphangiogenic variant of VEGF receptors

Humidification during laparoscopic surgery: overview of the clinical benefits of using humidified gas during laparoscopic surgery

Humidification during laparoscopic surgery: overview of the clinical benefits of using humidified gas during laparoscopic surgery

Defining the Acute Kidney Injury and Repair Transcriptome

Defining the Acute Kidney Injury and Repair Transcriptome

The duration of intra-abdominal hypertension strongly predicts outcomes for the critically ill surgical patients: a prospective observational study

The duration of intra-abdominal hypertension strongly predicts outcomes for the critically ill surgical patients: a prospective observational study

Unwrapping the origins and roles of the renal endothelium

Unwrapping the origins and roles of the renal endothelium

Differential Expression of Vegfr-2 and Its Soluble Form in Preeclampsia

Differential Expression of Vegfr-2 and Its Soluble Form in Preeclampsia

Thoracic epidural anesthesia: Effects on splanchnic circulation and implications in Anesthesia and Intensive care

Thoracic epidural anesthesia: Effects on splanchnic circulation and implications in Anesthesia and Intensive care

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers95

VEGF receptor signalling ? in control of vascular function

2,930 citations

A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress

2,419 citations

The stress response to trauma and surgery

2,091 citations

Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury

1,677 citations

Signaling Mechanisms Regulating Endothelial Permeability

1,632 citations

What is oxidative stress?

1,336 citations

Microvascular fluid exchange and the revised Starling principle

1,028 citations

Laparoscopic Live Donor Nephrectomy

1,002 citations

Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition

Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate

Vascular Endothelial Growth Factor Induces Rapid Phosphorylation of Tight Junction Proteins Occludin and Zonula Occluden 1

Hemodynamic Changes During Laparoscopic Cholecystectomy

The Endothelial Glycocalyx Protects Against Myocardial Edema

EFFECT OF INCREASED INTRA-ABDOMINAL PRESSURE ON MESENTERIC ARTERIAL AND INTESTINAL MUCOSAL BLOOD FLOW

Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential

Oxidized Lipoproteins Degrade the Endothelial Surface Layer

Inflammation- and ischemia-induced shedding of venular glycocalyx

Proteinuria and reduced kidney function in living kidney donors: A systematic review, meta-analysis, and meta-regression

Safety and Adequacy of Renal Transplant Protocol Biopsies

Endothelial Glycocalyx as an Additional Barrier Determining Extravasation of 6% Hydroxyethyl Starch or 5% Albumin Solutions in the Coronary Vascular Bed

Sepsis and Major Abdominal Surgery Lead to Flaking of the Endothelial Glycocalix

Novel biomarkers of acute kidney injury and failure: clinical applicability

Intra-abdominal hypertensionand acute renal failurein critically ill patients

Morphological and functional evidence for an important role of the endothelial cell glycocalyx in the glomerular barrier

Splanchnic microcirculatory changes during CO2 laparoscopy.

Effect of pneumoperitoneum on renal perfusion and function: A systematic review

Renal Dysfunction Associated with Intra-abdominal Hypertension and the Abdominal Compartment Syndrome

Atherogenic region and diet diminish glycocalyx dimension and increase intima-to-media ratios at murine carotid artery bifurcation

Fluid shear stress stimulates incorporation of hyaluronan into endothelial cell glycocalyx

Postoperative cell mediated immune response is better preserved after laparoscopic vs open colorectal resection in humans

Vascular integrins: pleiotropic adhesion and signaling molecules in vascular homeostasis and angiogenesis

Ischemic and non-ischemic acute kidney injury cause hepatic damage

Blood reflects tissue oxidative stress depending on biomarker and tissue studied

Cellular Fluid Mechanics and Mechanotransduction

Surgical Stress Response: Does Endoscopic Surgery Confer an Advantage?

Localization of the permeability barrier to solutes in isolated arteries by confocal microscopy

Antithrombin: in control of coagulation

Systematic review of oxidative stress associated with pneumoperitoneum

Two-Photon Microscopy for Imaging of the (Atherosclerotic) Vascular Wall: A Proof of Concept Study

Effect of Prolonged Pneumoperitoneum on Intraoperative Urine Output During Laparoscopic Gastric Bypass

Regulation of E‐Selectin, P‐Selectin, and Intercellular Adhesion Molecule 1 Expression in Mouse Cremaster Muscle Vasculature

The plasma ACTH, AVP, CRH and catecholamine responses to conventional and laparoscopic cholecystectomy

F2-isoprostanes are not just markers of oxidative stress

Biomarkers of Acute Kidney Injury

Regulation of glycosaminoglycan structure and atherogenesis

The role of intra-abdominal pressure on splanchnic and pulmonary hemodynamic and metabolic changes during carbon dioxide pneumoperitoneum

VEGF receptor signal transduction – A brief update

The role of endothelial function and its assessment in rheumatoid arthritis

Renal Damage Caused by Warm Ischaemia During Laparoscopic and Robot-Assisted Partial Nephrectomy: An Assessment Using Tc 99m-DTPA Glomerular Filtration Rate

Randomized comparison of the neuroendocrine response to laparoscopic cholecystectomy using either conventional or abdominal wall lift techniques

The effect of different intraabdominal pressures on lipid peroxidation and protein oxidation status during laparoscopic cholecystectomy

Integrins, cations and ligands: making the connection

Pneumoperitoneum Produces Reversible Renal Dysfunction in Animals with Normal and Chronically Reduced Renal Function

Differential actions of albumin and plasma on capillary solute permeability

Oxidative Stress in Laparoscopic Versus Open Abdominal Surgery: A Systematic Review

Evaluation of Oxidative Stress in Laparoscopic Cholecystectomy

Can preconditioning reduce laparoscopy-induced tissue injury?

Comparative Study of Adhesion Molecule Expression in Cultured Human Macro- and Microvascular Endothelial Cells

Dermatan sulfate is the predominant antithrombotic glycosaminoglycan in vessel walls: Implications for a possible physiological function of heparin cofactor II

Acute intestinal distress syndrome: the importance of intra-abdominal pressure.

Comparison of Peritoneal Oxidative Stress During Laparoscopy and Laparotomy

Catecholamine Release caused by Carbon Dioxide Insufflation during Laparoscopic Surgery

Renal hemodynamics during carbon dioxide pneumoperitoneum

Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute dengue virus infection

Effects of increased intra-abdominal pressure and volume expansion on renal function in the rat

Does splanchnic ischemia occur during laparoscopic cholecystectomy?

Effect of Pneumoperitoneum on Renal Tissue Oxygenation and Blood Flow in a Rat Model

Low‐pressure pneumoperitoneum during laparoscopic donor nephrectomy to optimize live donors’ comfort

The oxidative effect of prolonged CO2 pneumoperitoneum on renal tissue of rats

Oxidative stress in lung tissue induced by CO2 pneumoperitoneum in the rat

Antidiuretic Hormone Release During Laparoscopic Donor Nephrectomy

Minimal incision living donor nephrectomy: improvement in patient outcome

Renal Apoptosis Following Carbon Dioxide Pneumoperitoneum in a Rat Model

Changes in tissue-oxidative stress markers in an experimental model of laparoscopic donor nephrectomy.

The influence of periarterial papaverine application on intraoperative renal function and blood flow during laparoscopic donor nephrectomy in a pig model

Effects of carbon dioxide pneumoperitoneum on free radical formation in lung and liver tissues

N-acetylcysteine (NAC) Protects Against Acute Kidney Injury (AKI) Following Prolonged Pneumoperitoneum in the Rat

Impact of intraperitoneal pressure and duration of surgery on levels of tissue plasminogen activator and plasminogen activator inhibitor-1 mRNA in peritoneal tissues during laparoscopic surgery

Early Postnephrectomy Donor Renal Function: Laparoscopic versus Open Procedure

Cytokine elevation and transaminitis after laparoscopic donor nephrectomy

Role of angiotensin II under prolonged increased intraabdominal pressure (IAP) in pigs

Comparison of Changes in Tissue Oxidative-Stress Markers in Experimental Model of Open, Laparoscopic, and Retroperitoneoscopic Donor Nephrectomy

Resistive Index of the Remaining Kidney in Allograft Kidney Donors

Impact of Laparoscopic and Conventional Surgery on Kupffer Cells, Tumor-Associated CD44 Expression, and Intrahepatic Tumor Spread

Comparison of the Effects of Carbon Dioxide and Helium Pneumoperitoneum on Renal Function

Image-directed color Doppler ultrasound evaluation of the single kidney after unilateral nephrectomy in adults

An experimental study on the relationship of intra-abdominal pressure and renal ischemia.

Effects of Enalaprilat on the Renin-Angiotensin-Aldosterone System and on Renal Function during CO₂ Pneumoperitoneum

Urinary biomarkers after donor nephrectomy

Resistive Index of the Solitary Kidney: A Clinical Study of Normal Values

The physiologic and anesthetic considerations in elderly patients undergoing robotic renal surgery.

A Comparison of Recipient Renal Outcomes With Laparoscopic Versus Open Live Donor Nephrectomy

[Living donor kidney transplantation--a successful story. Very cost-effective--and the donors live long with good health].